Patents by Inventor Omar Bazirgan

Omar Bazirgan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HUMANIZED ANTIBODIES WITH ULTRALONG COMPLEMENTARY DETERMINING REGIONS
    Publication number: 20230287598
    Abstract: The present disclosure provides humanized antibodies, including antibodies comprising an ultralong CDR3 and uses thereof.
    Type: Application
    Filed: November 9, 2022
    Publication date: September 14, 2023
    Inventors: Omar BAZIRGAN, Miguel DE LOS RIOS
  • Humanized antibodies with ultralong complementary determining regions
    Patent number: 11530493
    Abstract: The present disclosure provides humanized antibodies, including antibodies comprising an ultralong CDR3 and uses thereof.
    Type: Grant
    Filed: March 26, 2020
    Date of Patent: December 20, 2022
    Assignee: TAURUS BIOSCIENCES, LLC
    Inventors: Omar Bazirgan, Miguel De Los Rios
  • Ultralong complementarity determining regions and uses thereof
    Patent number: 11390665
    Abstract: Disclosed herein are immunoglobulin constructs comprising at least one immunoglobulin domain or fragment thereof; and a therapeutic polypeptide or derivative or variant thereof attached to or inserted into said immunoglobulin domain. Also provided are immunoglobulin constructs comprising a mammalian immunoglobulin heavy chain comprising at least a portion of a knob domain in the complementarity-determining region 3 (CDR3H) or fragment thereof; and a therapeutic polypeptide attached to or inserted into said knob domain of the CDR3H. Also provided are immunoglobulin constructs comprising a mammalian immunoglobulin heavy chain comprising at least a portion of a stalk domain in the complementarity-determining region 3 (CDR3H) or fragment thereof; and a therapeutic polypeptide attached to or inserted into said stalk domain of the CDR3H. Also described herein are methods and compositions comprising the immunoglobulin constructs described herein for treatment and prevention of a disease or condition in a subject.
    Type: Grant
    Filed: January 14, 2020
    Date of Patent: July 19, 2022
    Assignee: The Scripps Research Institute
    Inventors: Vaughn Smider, Omar A. Bazirgan, Hongyuan Helen Mao, Peter Schultz, Feng Wang, Yong Zhang
  • COMBINATORIAL ANTIBODY LIBRARIES AND USES THEREOF
    Publication number: 20200399359
    Abstract: Methods for making a combinatorial antibody library from human germline segments are provided. Also provided are libraries of nucleic acid molecules compiled from germline segments encoding VL chains and libraries of nucleic acid molecules encoding VH chains, and resulting antibody libraries. The libraries are provided as addressable libraries. Methods for screening antibody libraries against a target protein antigen, and the identified or selected antibodies are provided.
    Type: Application
    Filed: August 25, 2020
    Publication date: December 24, 2020
    Applicant: Taurus Biosciences, LLC
    Inventors: Vaughn SMIDER, James GRAZIANO, Helen Hongyuan MAO, Byeong Doo SONG, Tyson CHASE, Omar BAZIRGAN
  • Combinatorial antibody libraries and uses thereof
    Patent number: 10774138
    Abstract: Methods for making a combinatorial antibody library from human germline segments are provided. Also provided are libraries of nucleic acid molecules compiled from germline segments encoding VL chains and libraries of nucleic acid molecules encoding VH chains, and resulting antibody libraries. The libraries are provided as addressable libraries. Methods for screening antibody libraries against a target protein antigen, and the identified or selected antibodies are provided.
    Type: Grant
    Filed: December 4, 2015
    Date of Patent: September 15, 2020
    Assignee: Taurus Biosciences, LLC
    Inventors: Vaughn Smider, James Graziano, Helen Hongyuan Mao, Byeong Doo Song, Tyson Chase, Omar Bazirgan
  • Ultralong complementarity determining regions and uses thereof
    Patent number: 10774132
    Abstract: Disclosed herein are immunoglobulin constructs comprising at least one immunoglobulin domain or fragment thereof; and a therapeutic polypeptide or derivative or variant thereof attached to or inserted into said immunoglobulin domain. Also provided are immunoglobulin constructs comprising a mammalian immunoglobulin heavy chain comprising at least a portion of a knob domain in the complementarity-determining region 3 (CDR3H) or fragment thereof; and a therapeutic polypeptide attached to or inserted into said knob domain of the CDR3H. Also provided are immunoglobulin constructs comprising a mammalian immunoglobulin heavy chain comprising at least a portion of a stalk domain in the complementarity-determining region 3 (CDR3H) or fragment thereof; and a therapeutic polypeptide attached to or inserted into said stalk domain of the CDR3H. Also described herein are methods and compositions comprising the immunoglobulin constructs described herein for treatment and prevention of a disease or condition in a subject.
    Type: Grant
    Filed: January 9, 2013
    Date of Patent: September 15, 2020
    Assignee: THE SCRIPPS RESEARCH INSTITTUE
    Inventors: Vaughn Smider, Omar A. Bazirgan, Hongyuan Helen Mao, Peter Schultz, Feng Wang, Yong Zhang
  • HUMANIZED ANTIBODIES WITH ULTRALONG COMPLEMENTARY DETERMINING REGIONS
    Publication number: 20200239599
    Abstract: The present disclosure provides humanized antibodies, including antibodies comprising an ultralong CDR3 and uses thereof.
    Type: Application
    Filed: March 26, 2020
    Publication date: July 30, 2020
    Applicant: Taurus Biosciences, LLC
    Inventors: Omar BAZIRGAN, Miguel DE LOS RIOS
  • HUMANIZED ANTIBODIES
    Publication number: 20200223944
    Abstract: The present disclosure provides humanized antibodies, including antibodies comprising an ultralong CDR3 and uses thereof.
    Type: Application
    Filed: January 6, 2020
    Publication date: July 16, 2020
    Inventors: Vaughn Smider, Omar Bazirgan, Hongyuan Helen Mao
  • ULTRALONG COMPLEMENTARITY DETERMINING REGIONS AND USES THEREOF
    Publication number: 20200181241
    Abstract: Disclosed herein are immunoglobulin constructs comprising at least one immunoglobulin domain or fragment thereof; and a therapeutic polypeptide or derivative or variant thereof attached to or inserted into said immunoglobulin domain. Also provided are immunoglobulin constructs comprising a mammalian immunoglobulin heavy chain comprising at least a portion of a knob domain in the complementarity-determining region 3 (CDR3H) or fragment thereof; and a therapeutic polypeptide attached to or inserted into said knob domain of the CDR3H. Also provided are immunoglobulin constructs comprising a mammalian immunoglobulin heavy chain comprising at least a portion of a stalk domain in the complementarity-determining region 3 (CDR3H) or fragment thereof; and a therapeutic polypeptide attached to or inserted into said stalk domain of the CDR3H. Also described herein are methods and compositions comprising the immunoglobulin constructs described herein for treatment and prevention of a disease or condition in a subject.
    Type: Application
    Filed: January 14, 2020
    Publication date: June 11, 2020
    Inventors: Vaughn SMIDER, Omar A. BAZIRGAN, Hongyuan Helen MAO, Peter SCHULTZ, Feng WANG, Yong Zhang
  • Humanized antibodies with ultralong complementary determining regions
    Patent number: 10640574
    Abstract: The present disclosure provides humanized antibodies, including antibodies comprising an ultralong CDR3 and uses thereof.
    Type: Grant
    Filed: July 18, 2014
    Date of Patent: May 5, 2020
    Assignee: Taurus Biosciences, LLC
    Inventors: Omar Bazirgan, Miguel De Los Rios
  • Humanized antibodies
    Patent number: 10562980
    Abstract: The present disclosure provides humanized antibodies, including antibodies comprising an ultralong CDR3 and uses thereof.
    Type: Grant
    Filed: November 1, 2017
    Date of Patent: February 18, 2020
    Assignee: The Scripps Research Institute
    Inventors: Vaughn Smider, Omar A. Bazirgan, Hongyuan Helen Mao
  • HUMANIZED ANTIBODIES
    Publication number: 20180222999
    Abstract: The present disclosure provides humanized antibodies, including antibodies comprising an ultralong CDR3 and uses thereof.
    Type: Application
    Filed: November 1, 2017
    Publication date: August 9, 2018
    Inventors: Vaughn SMIDER, Omar A. BAZIRGAN, Hongyuan Helen MAO
  • COMBINATORIAL ANTIBODY LIBRARIES AND USES THEREOF
    Publication number: 20160194627
    Abstract: Methods for making a combinatorial antibody library from human germline segments are provided. Also provided are libraries of nucleic acid molecules compiled from germline segments encoding VL chains and libraries of nucleic acid molecules encoding VH chains, and resulting antibody libraries. The libraries are provided as addressable libraries. Methods for screening antibody libraries against a target protein antigen, and the identified or selected antibodies are provided.
    Type: Application
    Filed: December 4, 2015
    Publication date: July 7, 2016
    Inventors: Vaughn SMIDER, James GRAZIANO, Helen Hongyuan MAO, Byeong Doo SONG, Tyson CHASE, Omar BAZIRGAN
  • ANTIBODIES WITH ULTRALONG COMPLEMENTARITY DETERMINING REGIONS
    Publication number: 20160168231
    Abstract: The present disclosure provides antibodies, including antibodies comprising ultralong CDR3 and uses thereof.
    Type: Application
    Filed: July 18, 2014
    Publication date: June 16, 2016
    Applicant: Fabrus, Inc.
    Inventors: Miguel DE LOS RIOS, Omar BAZIRGAN
  • HUMANIZED ANTIBODIES WITH ULTRALONG COMPLEMENTARY DETERMINING REGIONS
    Publication number: 20160159928
    Abstract: The present disclosure provides humanized antibodies, including antibodies comprising an ultralong CDR3 and uses thereof.
    Type: Application
    Filed: July 18, 2014
    Publication date: June 9, 2016
    Inventors: Omar BAZIRGAN, Miguel DE LOS RIOS
  • Combinatorial antibody libraries and uses thereof
    Patent number: 9221902
    Abstract: Methods for making a combinatorial antibody library from human germline segments are provided. Also provided are libraries of nucleic acid molecules compiled from germline segments encoding VL chains and libraries of nucleic acid molecules encoding VH chains, and resulting antibody libraries. The libraries are provided as addressable libraries. Methods for screening antibody libraries against a target protein antigen, and the identified or selected antibodies are provided.
    Type: Grant
    Filed: November 4, 2009
    Date of Patent: December 29, 2015
    Assignee: Fabrus, Inc.
    Inventors: Vaughn Smider, James Graziano, Helen Hongyuan Mao, Byeong Doo Song, Tyson Chase, Omar Bazirgan
  • HUMANIZED ANTIBODIES
    Publication number: 20150011431
    Abstract: The present disclosure provides humanized antibodies, including antibodies comprising an ultralong CDR3 (e.g. bovine) and uses thereof.
    Type: Application
    Filed: January 9, 2013
    Publication date: January 8, 2015
    Inventors: Vaughn Smider, Omar A. Bazirgan, Hongyuan Helen Mao
  • COMBINATORIAL ANTIBODY LIBRARIES AND USES THEREOF
    Publication number: 20120058906
    Abstract: Methods for making a combinatorial antibody library from human germline segments are provided. Also provided are libraries of nucleic acid molecules compiled from germline segments encoding VL chains and libraries of nucleic acid molecules encoding VH chains, and resulting antibody libraries. The libraries are provided as addressable libraries. Methods for screening antibody libraries against a target protein antigen, and the identified or selected antibodies are provided.
    Type: Application
    Filed: November 4, 2009
    Publication date: March 8, 2012
    Inventors: Vaughn Smider, James Graziano, Helen Hongyuan Mao, Byeong Doo Song, Tyson Case, Omar Bazirgan