Patents by Inventor Omar D. Al-hejaili

Omar D. Al-hejaili has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Buccal formulation of avanafil with enhanced bioavailability and prolonged duration
    Patent number: 11890380
    Abstract: A buccal tablet formulation has a polyvinylpyrrolidone K-90 as a solid dispersion polymer, a hydroxypropyl methylcellulose as a mucoadhesive polymer, a sodium deoxycholate as mucopenetration enhancer, a porous silicon dioxide (e.g., FujiSil), mannitol, and avanafil. The ratio of PVP K-90 to AVA is approximately 2:1 (e.g., 2.3:1 to 1.7:1) in the tablet. Methods of making the buccal tablet with enhanced bioavailability and prolonged duration and methods of using the formulation for the treatment of erectile dysfunction are also provided.
    Type: Grant
    Filed: March 28, 2023
    Date of Patent: February 6, 2024
    Assignee: KING ABDULAZIZ UNIVERSITY
    Inventors: Omar D. Al-hejaili, Khalid M. El-Say, Tarek A. Ahmed, Hossam S. El-Sawy, Fathy I. Abd-Allah
  • Buccal formulation of avanafil with enhanced bioavailability and prolonged duration
    Patent number: 11648205
    Abstract: A buccal tablet formulation has a polyvinylpyrrolidone K-90 as a solid dispersion polymer, a hydroxypropyl methylcellulose as a mucoadhesive polymer, a sodium deoxycholate as mucopenetration enhancer, a porous silicon dioxide (e.g., FujiSil), mannitol, and avanafil. The ratio of PVP K-90 to AVA is approximately 2:1 (e.g., 2.3:1 to 1.7:1) in the tablet. Methods of making the buccal tablet with enhanced bioavailability and prolonged duration and methods of using the formulation for the treatment of erectile dysfunction are also provided.
    Type: Grant
    Filed: October 14, 2022
    Date of Patent: May 16, 2023
    Assignee: KING ABDULAZIZ UNIVERSITY
    Inventors: Omar D. Al-hejaili, Khalid M. El-Say, Tarek A. Ahmed, Hossam S. El-Sawy, Fathy I. Abd-Allah
  • Transfersome-containing transdermal film formulations and methods of use
    Patent number: 11185513
    Abstract: A transdermal film formulation containing transfersomes incorporated onto the transdermal film is provided. The transfersomes include avanafil, a phospholipid, and an edge activator, wherein the phospholipid to avanafil ratio is from 3.5:1 to 4.5:1 and wherein the edge activator has a hydrophilic-lipophilic (HLB) value of 2-4. Methods of making the transdermal film formulation and methods of delivering avanafil using the transdermal film formulation are also provided.
    Type: Grant
    Filed: May 7, 2021
    Date of Patent: November 30, 2021
    Assignee: KING ABDULAZIZ UNIVERSITY
    Inventors: Khalid M. El-Say, Omar D. Al-hejaili, Abdullah A. Alamoudi, Osama A. A. Ahmed