Patents by Inventor Omar Rkyek

Omar Rkyek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles
    Patent number: 8735586
    Abstract: The present invention relates to a process for the regioselective synthesis of compounds of the formula I, wherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct copper catalyzed regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.
    Type: Grant
    Filed: December 22, 2009
    Date of Patent: May 27, 2014
    Assignee: Sanofi
    Inventors: Jorge Alonso, Andreas Lindenschmidt, Marc Nazaré, Matthias Urmann, Nis Halland, Omar Rkyek
  • Process for the palladium-catalyzed coupling of terminal alkynes with aryl tosylates
    Patent number: 8487109
    Abstract: The present invention relates to a process for the regioselective synthesis of compounds of the formula (I), wherein R1; R2; R3; R4; R5; J and W have the meanings indicated in the claims. The present invention provides an efficient and general palladium-catalyzed coupling process for aryl tosylates with terminal alkynes to a wide variety of substituted, multifunctional aryl-1-alkynes of the formula I.
    Type: Grant
    Filed: December 23, 2009
    Date of Patent: July 16, 2013
    Assignee: Sanofi
    Inventors: Omar Rkyek, Marc Nazare, Andreas Lindenschmidt, Matthias Urmann, Nis Halland, Jorge Alonso
  • Process for the palladium-catalyzed coupling of terminal alkynes with heteroaryl tosylates and heteroaryl benzenesulfonates
    Patent number: 8420812
    Abstract: A process for the palladium-catalyzed coupling of terminal alkynes with heteroaryl tosylates and heteroaryl benzenesulfonates The present invention relates to a process for the regioselective synthesis of compounds of the formula (I), wherein D, J and W have the meanings indicated in the claims. The present invention provides an efficient and general palladium-catalyzed coupling process of heteroaryl tosylates with terminal alkynes to a wide variety of substituted, multifunctional heteroaryl-1-alkynes of the formula I.
    Type: Grant
    Filed: December 23, 2009
    Date of Patent: April 16, 2013
    Assignee: Sanofi
    Inventors: Omar Rkyek, Marc Nazare, Andreas Lindenschmidt, Jorge Alonso, Matthias Urmann, Nis Halland
  • Transition metal catalyzed synthesis of 2H-indazoles
    Patent number: 8283476
    Abstract: The present invention relates to a process for the regioselective synthesis of compounds of the formula I, wherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct transition metal catalyzed process to a wide variety of multifunctional 2H-indazoles or 2H-azaindazoles of the formula (I) from 2-halo-phenylacetylenes or (2-sulfonato)phenylacetylenes and monosubstituted hydrazines.
    Type: Grant
    Filed: December 22, 2009
    Date of Patent: October 9, 2012
    Assignee: Sanofi
    Inventors: Nis Halland, Marc Nazare, Andreas Lindenschmidt, Jorge Alonso, Omar Rkyek, Matthias Urmann
  • Regioselective palladium catalyzed synthesis of benzimidazoles and azabenzimidazoles
    Patent number: 8188282
    Abstract: The present invention relates to a process for the regioselective synthesis of compounds of the formula I, wherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct palladium catalyzed, regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides useful for the production of pharmaceuticals, diagnostic agents, liquid crystals, polymers, herbicides, fungicidals, nematicidals, parasiticides, insecticides, acaricides and arthropodicides.
    Type: Grant
    Filed: January 14, 2009
    Date of Patent: May 29, 2012
    Assignee: Sanofi-Aventis
    Inventors: Jorge Alonso, Andreas Lindenschmidt, Marc Nazare, Nis Halland, Omar Rkyek, Matthias Urmann
  • Transition metal catalyzed synthesis of N-aminoindoles
    Patent number: 8026375
    Abstract: The present invention relates to a process for the regioselective synthesis of compounds of the formula I, wherein R0; R1; R2; R3; R4; R5; R6; A1; A2; A3; A4, Q, T and J have the meanings indicated in the claims. The present invention provides a direct transition metal catalyzed process to a wide variety of multifunctional N-aminoindole or N-amino-azaindoles of the formula I from 2-halo-phenylacetylenes or (2-sulfonato)phenyl-acetylenes and N,N-disubstituted hydrazines, useful for the production of pharmaceuticals, diagnostic agents, liquid crystals, polymers, herbicides, fungicidals, nematicidals, parasiticides, insecticides, acaricides and arthropodicides.
    Type: Grant
    Filed: October 9, 2009
    Date of Patent: September 27, 2011
    Assignee: Sanofi-Aventis
    Inventors: Nis Halland, Marc Nazare, Andreas Lindenschmidt, Omar Rkyek, Matthias Urmann, Jorge Alonso
  • Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles
    Publication number: 20100261909
    Abstract: The present invention relates to a process for the regioselective synthesis of compounds of the formula I, wherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct copper catalyzed regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.
    Type: Application
    Filed: December 22, 2009
    Publication date: October 14, 2010
    Applicant: sanofi-aventis
    Inventors: Jorge ALONSO, Andreas LINDENSCHMIDT, Marc NAZARÉ, Matthias URMANN, Nis HALLAND, Omar RKYEK
  • Process for the palladium-catalyzed coupling of terminal alkynes with heteroaryl tosylates and heteroaryl benzenesulfonates
    Publication number: 20100261900
    Abstract: A process for the palladium-catalyzed coupling of terminal alkynes with heteroaryl tosylates and heteroaryl benzenesulfonates The present invention relates to a process for the regioselective synthesis of compounds of the formula (I), wherein D, J and W have the meanings indicated in the claims. The present invention provides an efficient and general palladium-catalyzed coupling process of heteroaryl tosylates with terminal alkynes to a wide variety of substituted, multifunctional heteroaryl-1-alkynes of the formula I.
    Type: Application
    Filed: December 23, 2009
    Publication date: October 14, 2010
    Applicant: sanofi-aventis
    Inventors: Omar RKYEK, Marc NAZARE, Andreas LINDENSCHMIDT, Jorge ALONSO, Matthias URMANN, Nis HALLAND
  • Process for the palladium-catalyzed coupling of terminal alkynes with aryl tosylates
    Publication number: 20100261910
    Abstract: The present invention relates to a process for the regioselective synthesis of compounds of the formula (I), wherein R1; R2; R3; R4; R5; J and W have the meanings indicated in the claims. The present invention provides an efficient and general palladium-catalyzed coupling process for aryl tosylates with terminal alkynes to a wide variety of substituted, multifunctional aryl-1-alkynes of the formula I.
    Type: Application
    Filed: December 23, 2009
    Publication date: October 14, 2010
    Applicant: sanofi-aventis
    Inventors: Omar RKYEK, Marc NAZARE, Andreas LINDENSCHMIDT, Matthias URMANN, Nis HALLAND, Jorge ALONSO
  • Transition metal catalyzed synthesis of 2H-indazoles
    Publication number: 20100234601
    Abstract: The present invention relates to a process for the regioselective synthesis of compounds of the formula I, wherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct transition metal catalyzed process to a wide variety of multifunctional 2H-indazoles or 2H-azaindazoles of the formula (I) from 2-halo-phenylacetylenes or (2-sulfonato)phenylacetylenes and monosubstituted hydrazines.
    Type: Application
    Filed: December 22, 2009
    Publication date: September 16, 2010
    Applicant: SANOFI-AVENTIS
    Inventors: Nis HALLAND, Marc NAZARE, Andreas LINDENSCHMIDT, Jorge ALONSO, Omar RKYEK, Matthias URMANN
  • Regioselective metal catalyzed synthesis of annelated benzimidazoles and azabenzimidazoles
    Publication number: 20100216988
    Abstract: The present invention relates to a process for the regioselective synthesis of compounds of the formula I, wherein R1; R2; R3; R4; J1; J2; J3; J4 and G have the meanings indicated in the claims. The present invention provides a direct metal, e.g. palladium or copper, catalyzed, regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.
    Type: Application
    Filed: December 22, 2009
    Publication date: August 26, 2010
    Applicant: SANOFI-AVENTIS
    Inventors: Jorge ALONSO, Andreas LINDENSCHMIDT, Marc NAZARE, Omar RKYEK, Matthias URMANN, Nis HALLAND
  • Regioselective palladium catalyzed synthesis of benzimidazoles and azabenzimidazoles
    Publication number: 20090203912
    Abstract: The present invention relates to a process for the regioselective synthesis of compounds of the formula I, wherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct palladium catalyzed, regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides useful for the production of pharmaceuticals, diagnostic agents, liquid crystals, polymers, herbicides, fungicidals, nematicidals, parasiticides, insecticides, acaricides and arthropodicides.
    Type: Application
    Filed: January 14, 2009
    Publication date: August 13, 2009
    Applicant: SANOFI-AVENTIS
    Inventors: Jorge ALONSO, Andreas LINDENSCHMIDT, Marc NAZARE, Nis HALLAND, Omar RKYEK, Matthias URMANN