Patents by Inventor Omar S. Akbari

Omar S. Akbari has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240023528
    Abstract: Provided is a gene editing system comprising (i) a polynucleotide encoding an endonuclease under the control of an inducible expressing regulatory sequence; (ii) a guide polynucleotide targeting a female-essential genomic sequence that is required for female-specific viability, and (iii) a guide polynucleotide targeting a male sterility genomic sequence that is required for male-specific fertility. Additionally provided are insect eggs, an insects, and an insect populations, each of which is genetically modified by the gene editing system. Further provided are methods and compositions relating to producing such systems, insect eggs, insects, insect populations and uses thereof in reducing a wild-type insect population.
    Type: Application
    Filed: May 25, 2021
    Publication date: January 25, 2024
    Inventors: Omar S. Akbari, Nikolay Kandul
  • Patent number: 10966414
    Abstract: Embodiments provided herein relate to systems for synthetically-engineered reciprocal chromosomal translocation for gene insertion into a population of organisms such as insects.
    Type: Grant
    Filed: May 25, 2016
    Date of Patent: April 6, 2021
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Bruce A. Hay, Omar S. Akbari, Anna B. Buchman
  • Publication number: 20200404892
    Abstract: Embodiments provided herein relate to systems for synthetically-engineered reciprocal chromosomal translocation for gene insertion into a population of organisms such as insects.
    Type: Application
    Filed: August 27, 2020
    Publication date: December 31, 2020
    Inventors: Bruce A Hay, Omar S. Akbari, Anna B. Buchman
  • Publication number: 20200367479
    Abstract: Methods of the disclosed precision guided sterile insect technique (pgSIT) include methods for directing male sexing in a genetically modified insect and methods of producing a progeny of genetically modified sterile male insect egg. These methods include integrating at least one nucleic acid sequence into a genome of a first insect, the at least one nucleic acid sequence having at least one first guide polynucleotide targeting a female-essential genomic sequence that is required for female-specific viability, introducing an endonuclease into a second insect, and genetically crossing the first insect and the second insect thereby producing progeny expressing the endonuclease and the at least one nucleic acid sequence. For male sterility a second guide polynucleotide targets a male sterility genomic sequence that is required for male-specific sterility.
    Type: Application
    Filed: November 19, 2018
    Publication date: November 26, 2020
    Inventors: Nikolay P. Kandul, Omar S. Akbari
  • Patent number: 10791722
    Abstract: Embodiments provided herein relate to systems for synthetically-engineered reciprocal chromosomal translocation for gene insertion into a population of organisms such as insects.
    Type: Grant
    Filed: May 25, 2016
    Date of Patent: October 6, 2020
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Bruce A. Hay, Omar S. Akbari, Anna B. Buchman
  • Publication number: 20200270634
    Abstract: An insect gene drive system for biocontrol of a population of an insect is provided. The gene drive system includes: a) a first DNA sequence encoding a toxin under the control of a maternal germline-specific promoter active in the insect, with the first DNA sequence being linked to b) a second DNA sequence encoding an antidote under the control of an early embryo-specific promoter active in the insect. The toxin is expressed in maternal germline cells of the insect and results in maternal-effect lethality in the insect, and the antidote is expressed in embryos of the insect and counters the maternal-effect lethality. In some embodiments, the insect is Drosophila suzrukii.
    Type: Application
    Filed: January 25, 2017
    Publication date: August 27, 2020
    Applicant: The Regents of the University of California
    Inventors: Omar S. AKBARI, Anne BUCHMAN
  • Publication number: 20160345556
    Abstract: Embodiments provided herein relate to systems for synthetically-engineered reciprocal chromosomal translocation for gene insertion into a population of organisms such as insects.
    Type: Application
    Filed: May 25, 2016
    Publication date: December 1, 2016
    Inventors: Bruce A. Hay, Omar S. Akbari, Anna B. Buchman
  • Publication number: 20150237838
    Abstract: The present technology generally relates to compositions, methods, and populations that allow for the regulation of insect population.
    Type: Application
    Filed: February 25, 2015
    Publication date: August 27, 2015
    Inventors: BRUCE A. HAY, OMAR S. AKBARI
  • Publication number: 20140283155
    Abstract: Disclosed herein are components, systems and methods for regulating population of multicellular organisms, for example insects.
    Type: Application
    Filed: March 12, 2014
    Publication date: September 18, 2014
    Inventors: Omar S. Akbari, Katie L. Kennedy, Bruce A. Hay