Abstract: The present disclosure provides a method of detecting the presence or amount of a UBE3A protein in a sample, such as a human sample, using mass spectrometry based techniques. The methods described herein are useful for diagnosing Angelman syndrome, as well as monitoring disease progression and treatment effectiveness.

Abstract: System and method for early detection of vehicle parts failure are disclosed. The method includes identifying discriminative rules from unstructured and structured data corresponding to subsystems of a vehicle. Causal parts categories are mapped to the subsystems based on the discriminative rules to obtain a plurality of causal part-subsystem pairs. The causal part categories are representative of vehicle parts responsible for failure of corresponding subsystems. Scores are assigned to the causal part-subsystem pairs based on an occurrence of causal part categories to a corresponding subsystem within a source. An emerging issue score is computed based on the scores, a corresponding weightage associated with the sources of the causal part category, and an extent of coverage of the each causal part in each of the plurality of causal part-subsystem pairs. The emerging issue score is compared with the threshold vehicle part failure score to identify causal part categories associated with vehicle parts failure.

Abstract: System and method for early detection of vehicle parts failure are disclosed. The method includes identifying discriminative rules from unstructured and structured data corresponding to subsystems of a vehicle. Causal parts categories are mapped to the subsystems based on the discriminative rules to obtain a plurality of causal part-subsystem pairs. The causal part categories are representative of vehicle parts responsible for failure of corresponding subsystems. Scores are assigned to the causal part-subsystem pairs based on an occurrence of causal part categories to a corresponding subsystem within a source. An emerging issue score is computed based on the scores, a corresponding weightage associated with the sources of the causal part category, and an extent of coverage of the each causal part in each of the plurality of causal part-subsystem pairs. The emerging issue score is compared with the threshold vehicle part failure score to identify causal part categories associated with vehicle parts failure.