Abstract: A method for estimating an information unit represented by DNA strands, the method includes (a) sequencing the DNA strands to provide noisy copies of an encoded version of the information unit; wherein the information unit comprises information unit elements; (b) neural network (NN) processing the multiple noisy copies by one or more NNs to provide a soft estimate of the encoded information unit; wherein the soft estimate comprises estimated encoded information unit elements and an encoded information unit elements estimated confidence parameter; and (c) decoding the soft estimate of the encoded information unit to provide a prediction of the information unit.

Abstract: There may be provided method for estimating an information unit represented by a cluster of traces that are noisy copies of a synthesized strand, the method may include estimating the information unit by applying processing operations on r-tuples related to the traces, wherein r is smaller than a number (t) of traces of the cluster; wherein processing operations applied on at least some of the r-tuples comprise calculating a length of a shortest common supersequences (SCS) of the r-tuples.