Patents by Inventor Omid Harandi

Omid Harandi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Amplifiable RNAs for Therapeutic Cell Systems
    Publication number: 20220073875
    Abstract: This disclosure provides, among other things, amplifiable nucleic acid constructs for expressing a gene of interest in a cell, e.g., an erythroid cell. The amplifiable nucleic acid construct may contain the gene of interest and an RNA-dependent RNA polymerase (RdRP)-responsive 5? UTR, and may optionally further contain an RdRP-responsive 3? UTR. RdRP may also be provided, e.g., on the same construct or a different construct.
    Type: Application
    Filed: November 18, 2021
    Publication date: March 10, 2022
    Applicant: Rubius Therapeutics, Inc.
    Inventors: Qin Yu, Urjeet Khanwalkar, Omid Harandi, Ewan Dunn, Tanyaporn Pattarabanjird, Avak Kahvejian, Jordi Mata-Fink
  • AMPLIFIABLE RNAS FOR THERAPEUTIC CELL SYSTEMS
    Publication number: 20190330591
    Abstract: This disclosure provides, among other things, amplifiable nucleic acid constructs for expressing a gene of interest in a cell, e.g., an erythroid cell. The amplifiable nucleic acid construct may contain the gene of interest and an RNA-dependent RNA polymerase (RdRP)-responsive 5? UTR, and may optionally further contain an RdRP-responsive 3? UTR. RdRP may also be provided, e.g., on the same construct or a different construct.
    Type: Application
    Filed: January 10, 2019
    Publication date: October 31, 2019
    Inventors: Qin Yu, Urjeet Khanwalkar, Omid Harandi, Ewan Dunn, Tanyaporn Pattarabanjird, Avak Kahvejian, Jordi Mata-Fink
  • COMPOSITIONS AND METHODS RELATED TO THERAPEUTIC CELL SYSTEMS EXPRESSING EXOGENOUS RNA
    Publication number: 20190161730
    Abstract: The invention includes compositions and methods related to erythroid cells comprising exogenous RNA encoding a protein. The exogenous RNA can comprise a heterologous untranslated region comprising a regulatory element. Alternatively or in combination, the exogenous RNA can comprise chemical modifications.
    Type: Application
    Filed: July 7, 2017
    Publication date: May 30, 2019
    Inventors: Avak Kahvejian, Jordi Mata-Fink, Robert J. Deans, Omid Harandi, Urjeet Khanwalkar, Sneha Hariharan
  • LIPID NANOPARTICLE METHODS AND COMPOSITIONS FOR PRODUCING ENGINEERED ERYTHROID CELLS
    Publication number: 20190062788
    Abstract: Carriers such as lipid nanoparticles are useful for delivering payloads (such as RNA, DNA, proteins, or small molecules) to cells such as erythroid cells. This disclosure provides improved carriers that comprise a targeting agent that binds a cell surface receptor. In some embodiments, the cell surface receptor is one that undergoes a high rate of endocytosis.
    Type: Application
    Filed: August 21, 2018
    Publication date: February 28, 2019
    Inventors: Omid Harandi, Avak Kahvejian