Abstract: The present invention relates to neutralizing antibodies of the human pituitary adenylate cyclase activating polypeptide type I receptor (PAC1) and pharmaceutical compositions comprising such antibodies. Methods of treating or preventing headache conditions, such as migraine and cluster headache, using the neutralizing antibodies are also described.

Abstract: A method for analyzing an ultrasound image in the first trimester of pregnancy includes: acquiring an ultrasound image in the first trimester of pregnancy; and acquiring at least one of characteristics of uterus, fetus, placenta, gestational sac, and egg yolk related to the acquired ultrasound image, and determining a group pertinent to the acquired ultrasound image among a plurality of predesignated groups based on the acquired characteristic and the acquired ultrasound image, using an ultrasound image analysis device that has learned in a machine learning technique.

Abstract: An object management system, an aircraft design system, and a method for managing an object. A three-dimensional environment with a model of an object and an avatar representing a human operator from a viewpoint relative to the avatar is displayed on a display system. A motion of the human operator is detected. An interaction between the avatar and the model of the object is identified in real time using information about motions of the human operator that are detected in real time. The interaction changes a group of dimensions in the model of the object. Further, the interaction between the avatar and the model of the object in the three-dimensional environment is displayed on the display system, enabling design changes in the model of the object made by the human operator.

Abstract: A dynamic bionic heart phantom is used for an MRI system, a control method and a testing method. The dynamic bionic heart phantom includes a bionic heart phantom, a control system, positive pressure devices and a negative pressure device; the bionic heart phantom includes a water tank and a heart phantom arranged in the water tank, and the heart phantom is connected to the control system through four air pipes; the control system includes an antimagnetic control device and a control PC, and the antimagnetic control device is composed of a measurement and control module, four proportional flow values, a power module and a magnetic shielding box; the positive pressure devices, including gas, gas cylinders and pressure reducing valves, are connected to two gas inlet interfaces of the control system respectively; and the negative pressure device includes a vacuum pump and a negative pressure container.

Abstract: A fill adapter system for an infusion pump assembly. The system includes a reusable fill adapter base, the base including a volume control mechanism to adjust an available fill volume of a reservoir of the infusion pump assembly and a pump mechanism configured to pump air into a fluid vial.

Abstract: Enclosed are embodiments of an ML-based framework for drivable surface annotation. In an embodiment, a method comprises: obtaining, using at least one processor, multimodal map data for a geographic region; and automatically annotating, using the at least one processor, one or more semantic masks of the map data using a machine learning model.

Abstract: A design method for feedforward active noise control system is disclosed. Based on a target signal and a reference signal, a first adaptive system identifying unit is enabled to complete a first system identification process for producing a first adaptive filter, and then a second adaptive system identifying unit is enabled to complete a second system identification process for producing a second adaptive filter. After the second adaptive filter is converted to a digitally-controlled filter by using a system identification tool, the digitally-controlled filter is implemented into a DSP chip of a feedforward active noise control system. As a result, it is able to find that not only the computing loading of the DSP chip is significantly lowered while an adaptive algorithm executes an active noise control computing, but also the feedforward active noise control system exhibits a broad frequency bandwidth noise cancelling ability.

Abstract: An image decoder splits a block of a picture into a plurality of sub blocks in a first direction using a first partition mode; and decodes the plurality of sub blocks, wherein, when the block is sized N pixels by 2N pixels and the first direction is along the 2N pixels, N being an integer, the first partition mode includes splitting the block into the plurality of sub blocks including at least one sub block sized N/4 pixels by 2N pixels, and excludes splitting the block into two sub blocks sized N/2 pixels by 2N pixels.

Abstract: Pyrrolidine carboxamido derivatives, optical isomers thereof, and salts thereof that are able to prevent, improve, and/or treat inflammatory conditions, including inflammatory bowel disease, and methods for preparing and using the same are provided.

Abstract: A device is disclosed which includes, in one illustrative example, an integrated circuit die having an active surface and a molded body extending around a perimeter of the die, the molded body having lips that are positioned above a portion of the active surface of the die. Another illustrative example includes an integrated circuit die having an active surface, a molded body extending around a perimeter of the die and a CTE buffer material formed around at least a portion of the perimeter of the die adjacent the active surface of the die, wherein the CTE buffer material is positioned between a portion of the die and a portion of the molded body and wherein the CTE buffer material has a coefficient of thermal expansion that is intermediate a coefficient of thermal expansion for the die and a coefficient of thermal expansion for the molded body.

Abstract: Disclosed are a bifunctional peptide having the capability to reduce inflammation and the capability to facilitate differentiation of stem cells into chondrocytes and the use thereof. Advantageously, the bifunctional peptide is useful for the prevention or treatment of arthritis accompanied by inflammation and damage of cartilage tissue due to excellent effects of reducing inflammation and facilitating differentiation of stem cells into chondrocytes, can be easily applied to various surgical regenerative treatments including orthopedic treatments, and can shorten the treatment period.

Abstract: Provided is an encoder which includes circuitry and memory. The circuitry encodes an image block using the memory. In encoding the image block, the circuitry: obtains one or more size parameters related to a size of the image block; determines whether the one or more size parameters and one or more thresholds satisfy a determined relationship; encodes a split parameter when the one or more size parameters and the one or more thresholds are determined to satisfy the determined relationship, the split parameter indicating whether the image block is to be split into a plurality of partitions including a non-rectangular partition; and encodes the image block after splitting the image block into the plurality of partitions when the split parameter indicates that the image block is to be split into the plurality of partitions.

Abstract: A target account detection method and apparatus, an electronic device, and a storage medium. The method includes: determining an active behavior timing feature of a target account to be detected according to active behavior data of the target account; determining an account feature of the target account according to account data of the target account; predicting a first probability that the target account is of a target type; and determining, in response to the first probability being greater than a target probability threshold, that the target account is of the target type. Detection is performed in the dimension of timing, so that the impact of an account of a target type pretending to be a normal account on detection can be reduced, and more accounts of the target type can be detected, thereby enlarging the identification coverage.

Abstract: Disclosed are compounds that arc inhibitors of CD73 and arc useful in treating CD73-associated diseases or conditions, and compositions containing the compounds.

Abstract: Techniques are disclosed relating to maintaining a cache usable to locate data stored in a data structure. A computer system, in various embodiments, maintains a data structure having a plurality of levels that store files for a database. The files may include one or more records that each have a key and corresponding data. The computer system may also maintain a cache for the database whose entries store, for a key, an indication of a location of a corresponding record in a file of the data structure. In some embodiments, the computer system receives a request to access a particular record stored in the data structure where the request specifies a key usable to locate the particular record. The computer system may retrieve, from the cache via the key, a particular indication of a location of the particular record and may use the particular indication to access the particular record.

Abstract: A toy projectile launcher for launching projectiles, e.g, toy foam darts, from a detachable hopper. An agitating member inside the hopper enables the orderly descent of the projectiles within the hopper. A hopper cover has a collapsible ceiling with nested members and a ceiling plate to maintain the projectiles toward the bottom of the hopper. First and second catches coupled to the ceiling plate respectively engage openings in hopper walls to prevent the ceiling plate from collapsing into the cover when the hopper cover is closed. Where there are multiple vertically-spaced-apart openings in the hopper walls, the first and second catches may disengage from respective first openings, and then engage lower, second openings in the hopper walls, as the number of projectiles in the hopper drops and the ceiling plate descends in the hopper. A rotating gear advances projectiles from the firing chamber to flywheels for launch.

Abstract: A driving apparatus includes a body; at least one sensor that is exposed to an outside of the body and configured to sense a user input for controlling driving of the body; a controller configured to generate at least one control command for driving of the body according to the sensed user input; and a motor that is configured to generate a driving force for driving the body according to the generated at least one control command.

Abstract: An encoder includes circuitry and memory. The circuitry, in operation, generates a first coefficient value by applying a CCALF (cross component adaptive loop filtering) process to a first reconstructed image sample of a luma component. The circuitry generates a second coefficient value by applying an ALF (adaptive loop filtering) process to a second reconstructed image sample of a chroma component. The circuitry generates a third coefficient value by adding the first coefficient value to the second coefficient value, and encodes a third reconstructed image sample of the chroma component using the third coefficient value. The circuitry determines a first parameter having the same value for Cb component and Cr component of the chroma component. The circuitry determines, using the first parameter, a model of entropy coding from a plurality of models. The circuitry performs, using the model, the entropy coding of a second parameter of the CCALF process.

Abstract: Various embodiments relate to a stent assembly comprising a stent; a swellable coating disposed on at least a portion of an exterior surface of the stent; optionally, a carrier dispersed in the swellable coating and/or disposed on at least a portion of an exterior surface of the stent; and an active agent comprised in at least one of the swellable coating or the carrier, if present. Use of the stent assembly as a ureteric stent, and method of preparing a stent assembly are also provided.

Abstract: An encoder includes circuitry and memory connected to the circuitry, and the circuitry, in operation: determines, based on a width and a height of a block, whether or not to disable a prediction mode in which the block is split along a partitioning line defined by a distance and an angle and then prediction is performed; and encodes the block with the prediction mode disabled or not disabled according to a result of the determination on whether or not to disable the prediction mode. Here, the distance is the shortest distance between the center of the block and the partitioning line, and the angle is an angle representing a direction from the center of the block toward the partitioning line in the shortest distance. The circuitry determines to disable the prediction mode when (i) a width-to-height ratio is at least 8 or (ii) a height-to-width ratio is at least 8.