Patents by Inventor Onat Kadioglu

Onat Kadioglu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Prenylated isoflavones for treatment of subjects with multidrug-resistant cancer
    Patent number: 9974766
    Abstract: Prenylated isoflavones are suitable to specifically inhibit P-glycoprotein in multidrug-resistant cancer cells leading to an accumulation of cytotoxic compounds or therapeutic compounds in the cells while having exceptionally increased cytotoxic activity specifically towards multidrug-resistant cancer cells and while allowing for an increased activity of chemotherapeutic compounds towards which the cells are resistant. Also in accordance with the present invention is a method for specifically targeting cancer cells with multidrug-resistance as well as a method of potentiating the activity of a chemotherapeutic compound in multidrug-resistant cancer cells. In a further aspect, a kit including a prenylated isoflavone and a chemotherapeutic compound is provided.
    Type: Grant
    Filed: November 30, 2015
    Date of Patent: May 22, 2018
    Assignee: Macau University of Science and Technology
    Inventors: Kam Wai Wong, Yuen Kwan Law, Thomas Efferth, Onat Kadioglu, Liang Liu
  • PRENYLATED ISOFLAVONES FOR TREATMENT OF SUBJECTS WITH MULTIDRUG-RESISTANT CANCER
    Publication number: 20170151212
    Abstract: Prenylated isoflavones are suitable to specifically inhibit P-glycoprotein in multidrug-resistant cancer cells leading to an accumulation of cytotoxic compounds or therapeutic compounds in the cells while having exceptionally increased cytotoxic activity specifically towards multidrug-resistant cancer cells and while allowing for an increased activity of chemotherapeutic compounds towards which the cells are resistant. Also in accordance with the present invention is a method for specifically targeting cancer cells with multidrug-resistance as well as a method of potentiating the activity of a chemotherapeutic compound in multidrug-resistant cancer cells. In a further aspect, a kit including a prenylated isoflavone and a chemotherapeutic compound is provided.
    Type: Application
    Filed: November 30, 2015
    Publication date: June 1, 2017
    Inventors: Kam Wai Wong, Yuen Kwan Law, Thomas Efferth, Onat Kadioglu, Liang Liu