Patents by Inventor Ondrej Simo

Ondrej Simo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Solid State Forms Of Cabazitaxel And Processes For Preparation Thereof
    Publication number: 20150073159
    Abstract: The invention relates to solid state forms of Cabazitaxel, and processes for preparation, via novel synthetic intermediates, thereof, and formulations comprising one or more of the solid state forms of Cabazitaxel.
    Type: Application
    Filed: November 19, 2014
    Publication date: March 12, 2015
    Inventors: Ondrej SIMO, Pavel VRASPIR, Tomas HOLAS, Alexandr JEGOROV, Roman GABRIEL
  • Solid state forms of cabazitaxel and processes for preparation thereof
    Patent number: 8921411
    Abstract: The invention relates to solid state forms of Cabazitaxel, and processes for preparation, via novel synthetic intermediates, thereof, and formulations comprising one or more of the solid state forms of Cabazitaxel. The present invention further provides pharmaceutical compositions comprising one or more of the solid state forms of Cabazitaxel, and a method of treating hormone-refractory prostate cancer.
    Type: Grant
    Filed: July 1, 2013
    Date of Patent: December 30, 2014
    Assignee: Plus Chemicals SA
    Inventors: Ondrej Simo, Pavel Vraspir, Tomas Holas, Alexandr Jegorov, Roman Gabriel
  • SOLID STATE FORMS OF CABAZITAXEL AND PROCESSES FOR PREPARATION THEREOF
    Publication number: 20140011865
    Abstract: The invention relates to solid state forms of Cabazitaxel, and processes for preparation, via novel synthetic intermediates, thereof, and formulations comprising one or more of the solid state forms of Cabazitaxel. The present invention further provides pharmaceutical compositions comprising one or more of the solid state forms of Cabazitaxel, and a method of treating hormone-refractory prostate cancer.
    Type: Application
    Filed: July 1, 2013
    Publication date: January 9, 2014
    Applicant: PLUS CHEMICALS SA
    Inventors: Ondrej SIMO, Pavel Vraspir, Tomas Holas, Alexandr Jegorov, Roman Gabriel
  • PROCESS FOR THE PREPARATION OF N-PROTECTED-DECYLAMINOETHANAL
    Publication number: 20110009596
    Abstract: Compounds useful in the preparation of telavancin, for example, were prepared. These compounds include decylaminoethanal dialkyl acetals and N-protected decylaminoethanal dialkyl acetals, imidazolidine derivatives, and N-protected-decylaminoethanal.
    Type: Application
    Filed: July 8, 2010
    Publication date: January 13, 2011
    Applicant: Plus Chemicals SA
    Inventors: Ettore Bigatti, Deborah Bollini, Augusto Canavesi, Ondrej Simo
  • POLYMORPHS OF DASATINIB AND PROCESS FOR PREPARATION THEREOF
    Publication number: 20100256158
    Abstract: Provided is dasatinib, solvates thereof and their crystalline forms, methods for their preparation, and pharmaceutical compositions thereof.
    Type: Application
    Filed: June 14, 2010
    Publication date: October 7, 2010
    Inventors: Ondrej SIMO, Jirí Filipcik, Alexandr Martaus, Alexandr Jegorov, Ales Gavenda, Judith Aronhime, Pavel Vraspír, Tamás Koltai, Jirí Faustmann, Roman Gabriel
  • POLYMORPHS OF DASATINIB AND PROCESS FOR PREPARATION THEREOF
    Publication number: 20090118297
    Abstract: Provided is dasatinib, solvates thereof and their crystalline forms, methods for their preparation, and pharmaceutical compositions thereof.
    Type: Application
    Filed: October 23, 2008
    Publication date: May 7, 2009
    Inventors: Ondrej SIMO, Jiri Filipcik, Alexandr Martaus, Alexandr Jegorov, Ales Gavenda, Judith Aronhime, Pavel Vraspir, Tamas Koltai, Jiri Faustmann, Roman Gabriel
  • Process for preparing 5-bromo-3-[(R)-1-methyl-pyrrolidin-2-ylmethyl]-1H-indole
    Publication number: 20080319205
    Abstract: The invention encompasses a process for preparing 5-bromo-3-[(R)-1-methyl-pyrrolidin-2-ylmethyl]-1H-indole comprising reacting (R)-2-(5-bromo-1H-indole-3-carbonyl)-pyrrolidine-1-carboxylic acid benzyl ester with a reducing agent selected from the group consisting of sodium dihydro-bis(2-methoxyethoxy)aluminate, lithium tris[(3-ethyl-3-pentyl)oxy]aluminohydride, lithium tri-tert-butoxyaluminum hydride and diisobutylaluminium hydride. 5-bromo-3-[(R)-1-methyl-pyrrolidin-2-ylmethyl]-1H-indole is a key intermediate for preparing eletriptan and its salts thereof.
    Type: Application
    Filed: May 29, 2008
    Publication date: December 25, 2008
    Inventors: Roman Bednar, Ondrej Simo, Pavel Blatny