Patents by Inventor Onno Wouter Kranenburg

Onno Wouter Kranenburg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12351650
    Abstract: The present invention relates to a multispecific antibody comprising at least a FAP? binding region comprising a first heavy chain variable region and a first light chain variable region; and a DR4 binding region comprising a second heavy chain variable region and a second light chain variable region. The invention further provides pharmaceutical compositions comprising the antibodies and use of the antibodies for therapeutic and diagnostic procedures, in particular in cancer therapy.
    Type: Grant
    Filed: June 26, 2024
    Date of Patent: July 8, 2025
    Assignee: GENMAB A/S
    Inventors: Bart E.C.G. De Goeij, Ilse Jongerius, Grietje Andringa, Madelon Paauwe, Theodorus Sjouke Plantinga, David Satijn, Jamila Laoukili, Onno Wouter Kranenburg, Marije Overdijk
  • Publication number: 20250002610
    Abstract: The present invention relates to a multispecific antibody comprising at least a FAP? binding region comprising a first heavy chain variable region and a first light chain variable region; and a DR4 binding region comprising a second heavy chain variable region and a second light chain variable region. The invention further provides pharmaceutical compositions comprising the antibodies and use of the antibodies for therapeutic and diagnostic procedures, in particular in cancer therapy.
    Type: Application
    Filed: June 26, 2024
    Publication date: January 2, 2025
    Inventors: Bart E.C.G. De Goeij, Ilse Jongerius, Grietje Andringa, Madelon Paauwe, Theodorus Sjouuke Plantinga, David Satijn, Jamila Laoukili, Onno Wouter Kranenburg, Marije Overdijk
  • Publication number: 20090202980
    Abstract: The invention relates to the field of biochemistry, molecular biology, structural biology and medicine. More in particular, the invention relates to cross-? structures and the biological role of these cross-? structures.
    Type: Application
    Filed: March 21, 2006
    Publication date: August 13, 2009
    Applicant: Crossbeta Biosciences B.V.
    Inventors: Martijn Frans Ben Gerard Gebbink, Barend Bouma, Onno Wouter Kranenburg, Louise Maria Johanna Kroon
  • Publication number: 20080241165
    Abstract: The invention relates to the field of biochemistry, molecular biology, structural biology and medicine. More in particular, the invention relates to cross-? structures and the biological role of these cross-? structures. In one embodiment, the invention discloses a method for modulating extracellular protein degradation and/or protein clearance comprising modulating cross-?(beta) structure formation (and/or cross-? structure-mediated activity) of the protein present in the circulation.
    Type: Application
    Filed: October 31, 2007
    Publication date: October 2, 2008
    Applicant: Crossbeta Biosciences B.V.
    Inventors: Louise Maria Johanna Kroon-Batenburg, Barend Bouma, Onno Wouter Kranenburg, Martijn Frans Ben Gerard Gebbink Bunnik