Patents by Inventor Onorato Campopiano

Onorato Campopiano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Ketoreductase polypeptides for the production of azetidinone
    Patent number: 12049649
    Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
    Type: Grant
    Filed: June 24, 2021
    Date of Patent: July 30, 2024
    Assignee: Codexis, Inc.
    Inventors: Onorato Campopiano, Emily Mundorff, Birthe Borup, Rama Voladri
  • KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF AZETIDINONE
    Publication number: 20240141304
    Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
    Type: Application
    Filed: September 22, 2023
    Publication date: May 2, 2024
    Inventors: Onorato Campopiano, Emily Mundorff, Birthe Borup, Rama Voladri
  • Processes for the preparation of uracil derivatives
    Patent number: 11459305
    Abstract: The present invention relates to processes and intermediates for preparing Gonadotropin-Releasing Hormone (GnRH) receptor antagonists of structure (VI); and stereoisomers and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: January 10, 2020
    Date of Patent: October 4, 2022
    Assignee: Neurocrine Biosciences, Inc.
    Inventors: Donald J. Gallagher, Laszlo R. Treiber, Robert Michael Hughes, Onorato Campopiano, Peng Wang, Yuxin Zhao, Shine K. Chou, Michael Allen Ouellette, Donald Nicholas Hettinger
  • KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF AZETIDINONE
    Publication number: 20210324347
    Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
    Type: Application
    Filed: June 24, 2021
    Publication date: October 21, 2021
    Inventors: Onorato Campopiano, Emily Mundorff, Birthe Borup, Rama Voladri
  • Ketoreductase polypeptides for the production of azetidinone
    Patent number: 11078466
    Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
    Type: Grant
    Filed: February 13, 2020
    Date of Patent: August 3, 2021
    Assignee: Codexis, Inc.
    Inventors: Onorato Campopiano, Emily Mundorff, Birthe Borup, Rama Voladri
  • PROCESSES FOR THE PREPARATION OF URACIL DERIVATIVES
    Publication number: 20200255387
    Abstract: The present invention relates to processes and intermediates for preparing Gonadotropin-Releasing Hormone (GnRH) receptor antagonists of structure (VI); and stereoisomers and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: January 10, 2020
    Publication date: August 13, 2020
    Inventors: Donald J. GALLAGHER, Laszlo R. TREIBER, Robert Michael HUGHES, Onorato CAMPOPIANO, Peng WANG, Yuxin ZHAO, Shine K. CHOU, Michael Allen OUELLETTE, Donald Nicholas HETTINGER
  • KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF AZETIDINONE
    Publication number: 20200172880
    Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
    Type: Application
    Filed: February 13, 2020
    Publication date: June 4, 2020
    Inventors: Onorato Campopiano, Emily Mundorff, Birthe Borup, Rama Voladri
  • Ketoreductase polypeptides for the production of azetidinone
    Patent number: 10597641
    Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
    Type: Grant
    Filed: May 7, 2019
    Date of Patent: March 24, 2020
    Assignee: Codexis, Inc.
    Inventors: Onorato Campopiano, Emily Mundorff, Birthe Borup, Rama Voladri
  • Processes for the preparation of uracil derivatives
    Patent number: 10494347
    Abstract: The present invention relates to processes and intermediates for preparing Gonadotropin-Releasing Hormone (GnRH) receptor antagonists of structure (VI); and stereoisomers and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: December 6, 2017
    Date of Patent: December 3, 2019
    Assignee: Neurocrine Biosciences, Inc.
    Inventors: Donald J. Gallagher, Laszlo R. Treiber, Robert Michael Hughes, Onorato Campopiano, Peng Wang, Yuxin Zhao, Shine K. Chou, Michael Allen Ouellette, Donald Nicholas Hettinger
  • KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF AZETIDINONE
    Publication number: 20190256825
    Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
    Type: Application
    Filed: May 7, 2019
    Publication date: August 22, 2019
    Inventors: Onorato Campopiano, Emily Mundorff, Birthe Borup, Rama Voladri
  • PROCESSES FOR THE PREPARATION OF URACIL DERIVATIVES
    Publication number: 20190218191
    Abstract: The present invention relates to processes and intermediates for preparing Gonadotropin-Releasing Hormone (GnRH) receptor antagonists of structure (VI); and stereoisomers and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: June 27, 2018
    Publication date: July 18, 2019
    Inventors: Donald J. Gallagher, Laszlo R. Treiber, Robert Michael Hughes, Onorato Campopiano, Peng Wang, Yuxin Zhao, Shine K. Chou, Michael Allen Ouellette, Donald Nicholas Hettinger
  • Ketoreductase polypeptides for the production of azetidinone
    Patent number: 10329540
    Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: June 25, 2019
    Assignee: Codexis, Inc.
    Inventors: Onorato Campopiano, Emily Mundorff, Birthe Borup, Rama Voladri
  • PROCESSES FOR THE PREPARATION OF URACIL DERIVATIVES
    Publication number: 20180346428
    Abstract: The present invention relates to processes and intermediates for preparing Gonadotropin-Releasing Hormone (GnRH) receptor antagonists of structure (VI); and stereoisomers and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: December 6, 2017
    Publication date: December 6, 2018
    Inventors: Donald J. Gallagher, Laszio R. Treiber, Robert Michael Hughes, Onorato Campopiano, Peng Wang, Yuxin Zhao, Shine K. Chou, Michael Allen Ouellette, Donald Nicholas Hettinger
  • Processes for the preparation of uracil derivatives
    Patent number: 9868706
    Abstract: The present invention relates to processes and intermediates for preparing Gonadotropin-Releasing Hormone (GnRH) receptor antagonists of structure (VI); and stereoisomers and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: January 13, 2017
    Date of Patent: January 16, 2018
    Assignee: Neurocrine Biosciences, Inc.
    Inventors: Donald J. Gallagher, Laszlo R. Treiber, Robert Michael Hughes, Onorato Campopiano, Peng Wang, Yuxin Zhao, Shine K. Chou, Michael Allen Ouellette, Donald Nicholas Hettinger
  • PROCESSES FOR THE PREPARATION OF URACIL DERIVATIVES
    Publication number: 20170320836
    Abstract: The present invention relates to processes and intermediates for preparing Gonadotropin-Releasing Hormone (GnRH) receptor antagonists of structure (VI); and stereoisomers and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: January 13, 2017
    Publication date: November 9, 2017
    Inventors: Donald J. Gallagher, Laszlo R. Treiber, Robert Michael Hughes, Onorato Campopiano, Peng Wang, Yuxin Zhao, Shine K. Chou, Michael Allen Ouellette, Donald Nicholas Hettinger
  • KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF AZETIDINONE
    Publication number: 20170313992
    Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
    Type: Application
    Filed: June 23, 2017
    Publication date: November 2, 2017
    Inventors: Onorato Campopiano, Emily Mundorff, Birthe Borup, Rama Voladri
  • Ketoreductase polypeptides for the production of azetidinone
    Patent number: 9719071
    Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
    Type: Grant
    Filed: January 18, 2017
    Date of Patent: August 1, 2017
    Assignee: Codexis, Inc.
    Inventors: Onorato Campopiano, Emily Mundorff, Birthe Borup, Rama Voladri
  • KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF AZETIDINONE
    Publication number: 20170121689
    Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
    Type: Application
    Filed: January 18, 2017
    Publication date: May 4, 2017
    Inventors: Onorato Campopiano, Emily Mundorff, Birthe Borup, Rama Voladri
  • Ketoreductase polypeptides for the production of azetidinone
    Patent number: 9580694
    Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
    Type: Grant
    Filed: September 22, 2016
    Date of Patent: February 28, 2017
    Assignee: Codexis, Inc.
    Inventors: Onorato Campopiano, Emily Mundorff, Birthe Borup, Rama Voladri
  • KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF AZETIDINONE
    Publication number: 20170002333
    Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
    Type: Application
    Filed: September 22, 2016
    Publication date: January 5, 2017
    Inventors: Onorato Campopiano, Emily Mundorff, Birthe Borup, Rama Voladri