Patents by Inventor Onur Atasoylu

Onur Atasoylu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bicyclic Ureas As Kinase Inhibitors
    Publication number: 20240317744
    Abstract: The present application provides bicyclic urea compounds that modulate the activity of JAK2, which are useful in the treatment of various diseases, including cancer.
    Type: Application
    Filed: March 12, 2024
    Publication date: September 26, 2024
    Inventors: Xin Li, Oleg Vechorkin, Yanran Ai, Onur Atasoylu, Hang Thi Dang, Brent Douty, Chunhong He, Peng He, Michael Liang, Minh Nguyen, Evan Styduhar, Anlai Wang, Xiaozhao Wang, Hai Fen Ye, Eddy W. Yue, Ke Zhang, Peng Zhao
  • TRICYCLIC UREA COMPOUNDS AS JAK2 V617F INHIBITORS
    Publication number: 20240150354
    Abstract: The present application provides tricyclic urea compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.
    Type: Application
    Filed: August 24, 2023
    Publication date: May 9, 2024
    Inventors: Yanran Ai, Onur Atasoylu, Yu Bai, Joseph Barbosa, David M. Burns, Daniel Levy, Brent Douty, Hao Feng, Leah C. Konkol, Cheng-Tsung Lai, Xun Liu, Song Mei, Jun Pan, Haisheng Wang, Liangxing Wu, Wenqing Yao, Eddy W. Yue
  • Substituted pyrrolo[2,3-d]pyrimidine compounds as JAK2 V617F inhibitors
    Patent number: 11919908
    Abstract: The present application provides deazaguaine compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.
    Type: Grant
    Filed: December 20, 2021
    Date of Patent: March 5, 2024
    Assignee: Incyte Corporation
    Inventors: Andrew W. Buesking, Onur Atasoylu, Cheng-Tsung Lai, Padmaja Polam, Liangxing Wu, Wenqing Yao
  • Tricyclic urea compounds as JAK2 V617F inhibitors
    Patent number: 11780840
    Abstract: The present application provides tricyclic urea compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.
    Type: Grant
    Filed: July 1, 2021
    Date of Patent: October 10, 2023
    Assignee: Incyte Corporation
    Inventors: Yanran Ai, Onur Atasoylu, Yu Bai, Joseph Barbosa, David M. Burns, Daniel Levy, Brent Douty, Hao Feng, Leah C. Konkol, Cheng-Tsung Lai, Xun Liu, Song Mei, Jun Pan, Haisheng Wang, Liangxing Wu, Wenqing Yao, Eddy W. Yue
  • Tricyclic pyridone compounds as JAK2 V617F inhibitors
    Patent number: 11767323
    Abstract: The present application provides tricyclic pyridone compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.
    Type: Grant
    Filed: July 1, 2021
    Date of Patent: September 26, 2023
    Assignee: Incyte Corporation
    Inventors: Kai Liu, Onur Atasoylu, Yu Bai, Andrew W. Buesking, Leah C. Konkol, Cheng-Tsung Lai, Song Mei, Jun Pan, Liangxing Wu, Wenqing Yao
  • DEAZAGUAINE COMPOUNDS AS JAK2 V617F INHIBITORS
    Publication number: 20220213108
    Abstract: The present application provides deazaguaine compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.
    Type: Application
    Filed: December 20, 2021
    Publication date: July 7, 2022
    Inventors: Andrew W. Buesking, Onur Atasoylu, Cheng-Tsung Lai, Padmaja Polam, Liangxing Wu, Wenqing Yao
  • TRICYCLIC UREA COMPOUNDS AS JAK2 V617F INHIBITORS
    Publication number: 20220169649
    Abstract: The present application provides tricyclic urea compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.
    Type: Application
    Filed: July 1, 2021
    Publication date: June 2, 2022
    Inventors: Yanran Ai, Onur Atasoylu, Yu Bai, Joseph Barbosa, David M. Burns, Daniel Levy, Brent Douty, Hao Feng, Leah C. Konkol, Cheng-Tsung Lai, Xun Liu, Song Mei, Jun Pan, Haisheng Wang, Liangxing Wu, Wenqing Yao, Eddy W. Yue
  • TRICYCLIC PYRIDONE COMPOUNDS AS JAK2 V617F INHIBITORS
    Publication number: 20220002299
    Abstract: The present application provides tricyclic pyridone compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.
    Type: Application
    Filed: July 1, 2021
    Publication date: January 6, 2022
    Inventors: Kai Liu, Onur Atasoylu, Yu Bai, Andrew W. Buesking, Leah C. Konkol, Cheng-Tsung Lai, Song Mei, Jun Pan, Liangxing Wu, Wenqing Yao
  • Cyanoindazole compounds and uses thereof
    Patent number: 10722495
    Abstract: Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: July 28, 2020
    Assignee: Incyte Corporation
    Inventors: Oleg Vechorkin, Onur Atasoylu, Hai Fen Ye, Kai Liu, Ke Zhang, Wenqing Yao
  • CYANOINDAZOLE COMPOUNDS AND USES THEREOF
    Publication number: 20190076401
    Abstract: Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.
    Type: Application
    Filed: September 7, 2018
    Publication date: March 14, 2019
    Inventors: Oleg Vechorkin, Onur Atasoylu, Hai Fen Ye, Kai Liu, Ke Zhang, Wenqing Yao
  • Cycloalkyl-dione derivatives and methods of their use
    Patent number: 8530520
    Abstract: The present invention is directed to carboxylic acid-containing pharmaceutical compounds where the carboxylic acid moieties have been substituted with cycloalkyl-dione derivatives, as well as tautomers and pharmaceutically acceptable salt forms thereof. These bioisosteric replacements improve the compound's ability to effectively cross the blood brain barrier and result in improved pharmacokinetic, toxicological, and/or safety profiles.
    Type: Grant
    Filed: June 6, 2012
    Date of Patent: September 10, 2013
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: Onur Atasoylu, Carlo Ballatore, Kurt R. Brunden, Longchuan Huang, Donna M. Huryn, Michael James, Virginia M. Y. Lee, Francesco Piscitelli, Amos B. Smith, III, James Soper, John Q. Trojanowski
  • Cycloalkyl-dione Derivatives And Methods Of Their Use
    Publication number: 20120329877
    Abstract: The present invention is directed to compounds of formula I: wherein A is n is 0, 1, or 2; m is 0 or 1; R1 is H or C1-6alkyl and R2 is H, C1-6 alkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; and X is O or N; as well as tautomers and pharmaceutically acceptable salt forms thereof. Uses of these compounds are also described.
    Type: Application
    Filed: June 6, 2012
    Publication date: December 27, 2012
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Onur Atasoylu, Carlo Ballatore, Kurt R. Brunden, Longchun Huang, Donna M. Huryn, Michael James, Virginia M.Y. Lee, Francesco Piscitelli, Amos B. Smith, III, James Soper, John Q. Trojanowski