Patents by Inventor Onur Cil

Onur Cil has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CFTR REGULATORS AND METHODS OF USE THEREOF
    Publication number: 20260103446
    Abstract: Provided herein are compounds that activate CFTR and methods for treating constipation, dry eye disorders, and other diseases and disorders.
    Type: Application
    Filed: July 14, 2025
    Publication date: April 16, 2026
    Inventors: Alan S. VERKMAN, Marc H. LEVIN, Onur CIL, Sujin LEE
  • CFTR regulators and methods of use thereof
    Patent number: 12503447
    Abstract: Provided herein are compounds that activate CFTR and methods for treating constipation, dry eye disorders, and other diseases and disorders.
    Type: Grant
    Filed: April 8, 2021
    Date of Patent: December 23, 2025
    Assignee: The Regents of the University of California
    Inventors: Alan S. Verkman, Marc H. Levin, Onur Cil, Mark J. Kurth
  • CFTR regulators and methods of use thereof
    Patent number: 12391654
    Abstract: Provided herein are compounds that activate CFTR and methods for treating constipation, dry eye disorders, and other diseases and disorders.
    Type: Grant
    Filed: May 31, 2024
    Date of Patent: August 19, 2025
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Alan S. Verkman, Marc H. Levin, Onur Cil, Sujin Lee
  • CFTR REGULATORS AND METHODS OF USE THEREOF
    Publication number: 20250109113
    Abstract: Provided herein are compounds that activate CFTR and methods for treating constipation, dry eye disorders, and other diseases and disorders.
    Type: Application
    Filed: May 31, 2024
    Publication date: April 3, 2025
    Inventors: Alan S. VERKMAN, Marc H. LEVIN, Onur CIL, Sujin LEE
  • SLC26A3 INHIBITORS AND USE THEREOF
    Publication number: 20250073242
    Abstract: Provided herein are inhibitors of SLC26A3, which is an anion (Cl?, HCO3?, oxalate) exchanger expressed in intestinal epithelial cells. SLC26A3 inhibitors have potential utility for treatment of constipation including chronic idiopathic constipation (CIC), opioid-induced constipation (OIC), constipation-predominant irritable bowel syndrome (IBS-C), cystic fibrosis-associated constipation, meconium ileus, distal intestinal obstruction syndrome, calcium oxalate kidney stone disease, enteric hyperoxaluria and primary hyperoxalurias.
    Type: Application
    Filed: July 29, 2022
    Publication date: March 6, 2025
    Inventors: Alan S. VERKMAN, Onur CIL, Peter M. HAGGIE
  • SLC26A3 inhibitors and use thereof
    Patent number: 12187694
    Abstract: Provided herein are inhibitors of SLC26A3, which is an anion (Cl?, HCO3?, oxalate) exchanger expressed in intestinal epithelial cells. SLC26A3 inhibitors have potential utility for treatment of constipation including chronic idiopathic constipation (CIC), opioid-induced constipation (OIC), constipation-predominant irritable bowel syndrome (IBS-C), cystic fibrosis-associated constipation, meconium ileus, distal intestinal obstruction syndrome, calcium oxalate kidney stone disease, enteric hyperoxaluria and primary hyperoxalurias.
    Type: Grant
    Filed: January 18, 2023
    Date of Patent: January 7, 2025
    Assignee: The Regents of the University of California
    Inventors: Alan S. Verkman, Onur Cil, Peter M. Haggie
  • USE OF CALCIUM SENSING RECEPTOR ANTAGONISTS FOR TREATING OCULAR DISORDERS
    Publication number: 20240408005
    Abstract: Disclosed herein include therapy for treating ocular disorders such as dry eye disease by targeting calcium sensitive receptor (CaSR), a regulator of ocular surface ion transport.
    Type: Application
    Filed: June 7, 2024
    Publication date: December 12, 2024
    Inventors: Onur Cil, Neel Pasricha
  • CFTR regulators and methods of use thereof
    Patent number: 12065412
    Abstract: Provided herein are compounds that activate CFTR and methods for treating constipation, dry eye disorders, and other diseases and disorders.
    Type: Grant
    Filed: May 11, 2023
    Date of Patent: August 20, 2024
    Assignee: The Regents of the University of California
    Inventors: Alan S. Verkman, Marc H. Levin, Onur Cil, Sujin Lee
  • CFTR REGULATORS AND METHODS OF USE THEREOF
    Publication number: 20230357170
    Abstract: Provided herein are compounds that activate CFTR and methods for treating constipation, dry eye disorders, and other diseases and disorders.
    Type: Application
    Filed: May 11, 2023
    Publication date: November 9, 2023
    Inventors: Alan S. VERKMAN, Marc H. LEVIN, Onur CIL, Sujin LEE
  • SLC26A3 INHIBITORS AND USE THEREOF
    Publication number: 20230339878
    Abstract: Provided herein are inhibitors of SLC26A3, which is an anion (Cl-, HCO3-, oxalate) exchanger expressed in intestinal epithelial cells. SLC26A3 inhibitors have potential utility for treatment of constipation including chronic idiopathic constipation (CIC), opioid-induced constipation (OIC), constipation-predominant irritable bowel syndrome (IBS-C), cystic fibrosis-associated constipation, meconium ileus, distal intestinal obstruction syndrome, calcium oxalate kidney stone disease, enteric hyperoxaluria and primary hyperoxalurias.
    Type: Application
    Filed: January 18, 2023
    Publication date: October 26, 2023
    Inventors: Alan S. VERKMAN, Onur CIL, Peter M. HAGGIE
  • SLC26A3 inhibitors and use thereof
    Patent number: 11591304
    Abstract: Provided herein are inhibitors of SLC26A3, which is an anion (CV, HCO3, oxalate) exchanger expressed in intestinal epithelial cells. SLC26A3 inhibitors have potential utility for treatment of constipation including chronic idiopathic constipation (CIC), opioid-induced constipation (OIC), constipation-predominant irritable bowel syndrome (IBS-C), cystic fibrosis-associated constipation, meconium ileus, distal intestinal obstruction syndrome, calcium oxalate kidney stone disease, enteric hyperoxaluria and primary hyperoxalurias.
    Type: Grant
    Filed: April 25, 2019
    Date of Patent: February 28, 2023
    Assignee: The Regents of the University of California
    Inventors: Alan S. Verkman, Onur Cil, Peter M. Haggie
  • CFTR REGULATORS AND METHODS OF USE THEREOF
    Publication number: 20220081402
    Abstract: Provided herein are compounds that activate CFTR and methods for treating constipation, dry eye disorders, and other diseases and disorders.
    Type: Application
    Filed: November 23, 2021
    Publication date: March 17, 2022
    Inventors: Alan S. VERKMAN, Marc H. LEVIN, Onur CIL, Sujin LEE
  • CFTR regulators and methods of use thereof
    Patent number: 11230535
    Abstract: Provided herein are compounds that activate CFTR and methods for treating constipation, dry eye disorders, and other diseases and disorders.
    Type: Grant
    Filed: February 7, 2020
    Date of Patent: January 25, 2022
    Assignee: The Regents of the University of California
    Inventors: Alan S. Verkman, Marc H. Levin, Onur Cil, Sujin Lee
  • CFTR regulators and methods of use thereof
    Patent number: 11192869
    Abstract: Provided herein are compounds that activate CFTR and methods for treating constipation, dry eye disorders or other diseases and disorders.
    Type: Grant
    Filed: October 28, 2019
    Date of Patent: December 7, 2021
    Assignee: The Regents of the University of California
    Inventors: Alan S. Verkman, Marc H. Levin, Onur Cil
  • SLC26A3 INHIBITORS AND USE THEREOF
    Publication number: 20210363123
    Abstract: Provided herein are inhibitors of SLC26A3, which is an anion (CV, HCO3, oxalate) exchanger expressed in intestinal epithelial cells. SLC26A3 inhibitors have potential utility for treatment of constipation including chronic idiopathic constipation (CIC), opioid-induced constipation (OIC), constipation-predominant irritable bowel syndrome (IBS-C), cystic fibrosis-associated constipation, meconium ileus, distal intestinal obstruction syndrome, calcium oxalate kidney stone disease, enteric hyperoxaluria and primary hyperoxalurias.
    Type: Application
    Filed: April 25, 2019
    Publication date: November 25, 2021
    Inventors: Alan S. VERKMAN, Onur CIL, Peter M. HAGGIE
  • CFTR REGULATORS AND METHODS OF USE THEREOF
    Publication number: 20210347742
    Abstract: Provided herein are compounds that activate CFTR and methods for treating constipation, dry eye disorders, and other diseases and disorders.
    Type: Application
    Filed: April 8, 2021
    Publication date: November 11, 2021
    Inventors: Alan S. Verkman, Marc H. Levin, Onur Cil, Mark J. Kurth
  • CFTR regulators and methods of use thereof
    Patent number: 11084795
    Abstract: Provided herein are compounds that activate CFTR and methods for treating constipation, dry eye disorders, and other diseases and disorders.
    Type: Grant
    Filed: December 23, 2016
    Date of Patent: August 10, 2021
    Assignee: The Regents of the University of California
    Inventors: Alan S. Verkman, Marc H. Levin, Onur Cil, Mark J. Kurth
  • Small molecule inhibitors of pendrin ion exchange and pharmaceutical compositions
    Patent number: 10702506
    Abstract: Provided herein are small molecule inhibitors of pendrin. More specifically, the small molecules disclosed herein may be used to inhibit pendrin-mediated anion exchange. These small molecules may be used for treatment of diseases and disorders that are treatable by inhibiting pendrin, such as cystic fibrosis, rhinitis, chronic rhinosinusitis, exposure to an industrial toxin, certain viral infections, certain bacterial infections, and chronic obstructive pulmonary disease. The small molecules may further be used to potentiate a diuretic effect of a diuretic compound. The small molecules may additionally be used to treat hypertension or thyroid conditions.
    Type: Grant
    Filed: February 24, 2017
    Date of Patent: July 7, 2020
    Assignee: The Regents of the University of California
    Inventors: Alan S. Verkman, Peter M. Haggie, Onur Cil
  • CFTR REGULATORS AND METHODS OF USE THEREOF
    Publication number: 20200181097
    Abstract: Provided herein are compounds that activate CFTR and methods for treating constipation, dry eye disorders, and other diseases and disorders.
    Type: Application
    Filed: February 7, 2020
    Publication date: June 11, 2020
    Inventors: Alan S. VERKMAN, Marc H. LEVIN, Onur CIL, Sujin LEE
  • CFTR REGULATORS AND METHODS OF USE THEREOF
    Publication number: 20200140402
    Abstract: Provided herein are compounds that activate CFTR and methods for treating constipation, dry eye disorders or other diseases and disorders.
    Type: Application
    Filed: October 28, 2019
    Publication date: May 7, 2020
    Inventors: Alan S. VERKMAN, Marc H. LEVIN, Onur Cil