Patents by Inventor Onyinyechi Chimaokereke

Onyinyechi Chimaokereke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Detection of DNA methylation
    Patent number: 11072817
    Abstract: In a first aspect, the invention concerns a method for detecting or quantifying DNA methylation at a locus. In one embodiment, a methylation-sensitive endonuclease is formulated together with a polymerase enzyme in an appropriate reaction mixture such that amplification of DNA occurs in a methylation specific manor. Quantitative DNA amplification at selected loci can be used to determine the level of methylation. Kits and reagents for performing such methods are also provided.
    Type: Grant
    Filed: August 22, 2017
    Date of Patent: July 27, 2021
    Assignee: ZYMO RESEARCH CORPORATION
    Inventors: Xiyu Jia, Onyinyechi Chimaokereke, Lam Nguyen
  • DETECTION OF DNA METHYLATION
    Publication number: 20180135113
    Abstract: In a first aspect, the invention concerns a method for detecting or quantifying DNA methylation at a locus. In one embodiment, a methylation-sensitive endonuclease is formulated together with a polymerase enzyme in an appropriate reaction mixture such that amplification of DNA occurs in a methylation specific manor. Quantitative DNA amplification at selected loci can be used to determine the level of methylation. Kits and reagents for performing such methods are also provided.
    Type: Application
    Filed: August 22, 2017
    Publication date: May 17, 2018
    Inventors: Xiyu Jia, Onyinyechi Chimaokereke, Lam Nguyen
  • DETECTION OF DNA METHYLATION
    Publication number: 20130065233
    Abstract: In a first aspect, the invention concerns a method for detecting or quantifying DNA methylation at a locus. In one embodiment, a methylation-sensitive endonuclease is formulated together with a polymerase enzyme in an appropriate reaction mixture such that amplification of DNA occurs in a methylation specific manor. Quantitative DNA amplification at selected loci can be used to determine the level of methylation. Kits and reagents for performing such methods are also provided.
    Type: Application
    Filed: March 2, 2011
    Publication date: March 14, 2013
    Applicant: ZYMO RESEARCH CORPORATION
    Inventors: Xiyu Jia, Onyinyechi Chimaokereke, Lam Nguyen