Patents by Inventor Opendra Narayan

Opendra Narayan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20120207782
    Abstract: The present invention is directed to a DNA vaccine for immunization against HIV. The invention comprises a DNA molecule that has a sequence encoding a plurality of viral proteins capable of stimulating an immune response against HIV. The DNA molecule is rendered safe for use as a vaccine by the disruption of genes encoding reverse transcriptase, integrase, and Vif. The DNA molecule is further rendered safe by at least a partial deletion of the 3? LTR.
    Type: Application
    Filed: July 18, 2011
    Publication date: August 16, 2012
    Applicants: University of Kansas Medical Center, National Institute for Agriculture Research
    Inventors: Opendra Narayan, Euan Narayan, Yahia Chebloune
  • Publication number: 20120020999
    Abstract: The present invention is directed to a DNA vaccine for immunization against HIV. The invention comprises a DNA molecule that has a sequence encoding a plurality of viral proteins capable of stimulating an immune response against HIV. The DNA molecule is rendered safe for use as a vaccine by the disruption of genes encoding reverse transcriptase, integrase, and Vif. The DNA molecule is further rendered safe by at least a partial deletion of the 3? LTR.
    Type: Application
    Filed: July 18, 2011
    Publication date: January 26, 2012
    Applicant: UNIVERSITY OF KANSAS MEDICAL CENTER
    Inventors: Opendra Narayan, Zhenqian Liu
  • Publication number: 20120021000
    Abstract: The present invention is directed to a DNA vaccine for immunization against HIV. The invention comprises a DNA molecule that has a sequence encoding a plurality of viral proteins capable of stimulating an immune response against HIV. The DNA molecule is rendered safe for use as a vaccine by the disruption of genes encoding reverse transcriptase, integrase, and Vif. The DNA molecule is further rendered safe by at least a partial deletion of the 3? LTR.
    Type: Application
    Filed: July 18, 2011
    Publication date: January 26, 2012
    Applicant: UNIVERSITY OF KANSAS MEDICAL CENTER
    Inventors: Opendra Narayan, Zhenqian Liu
  • Patent number: 8003113
    Abstract: The present invention is directed to a DNA vaccine for immunization against HIV. The invention comprises a DNA molecule that has a sequence encoding a plurality of viral proteins capable of stimulating an immune response against HIV. The DNA molecule is rendered safe for used as a vaccine by the disruption of genes encoding reverse transcriptase, integrase, and Vif. The DNA molecule is further rendered safe by at least a partial deletion of the 3? LTR.
    Type: Grant
    Filed: February 9, 2009
    Date of Patent: August 23, 2011
    Inventors: Opendra Narayan, Zhenqian Liu
  • Publication number: 20100291143
    Abstract: A method of treating or preventing SHIV or HIV infection in a subject comprising administering a therapeutically effective amount of a antisense IL-4. The antisense IL-4 inhibits viral replication in the liver, lungs, spleen, and even the lymph nodes of the subject. Further, the antisense IL-4 can be used in combination with other antiretroviral agents or vaccines.
    Type: Application
    Filed: June 10, 2009
    Publication date: November 18, 2010
    Applicant: UNIVERSITY OF KANSAS MEDICAL CENTER
    Inventors: Opendra Narayan, Shilpa Buch
  • Publication number: 20090233857
    Abstract: The present invention is directed to a DNA vaccine for immunization against HIV. The invention comprises a DNA molecule that has a sequence encoding a plurality of viral proteins capable of stimulating an immune response against HIV. The DNA molecule is rendered safe for used as a vaccine by the disruption of genes encoding reverse transcriptase, integrase, and Vif. The DNA molecule is further rendered safe by at least a partial deletion of the 3? LTR.
    Type: Application
    Filed: February 9, 2009
    Publication date: September 17, 2009
    Applicant: University of Kansas Medical Center
    Inventors: Opendra Narayan, Zhenqian Liu
  • Patent number: 7585675
    Abstract: A method of treating or preventing SHIV or HIV infection in a subject comprising administering a therapeutically effective amount of a antisense IL-4. The antisense IL-4 inhibits viral replication in the liver, lungs, spleen, and even the lymph nodes of the subject. Further, the antisense IL-4 can be used in combination with other antiretroviral agents or vaccines.
    Type: Grant
    Filed: November 15, 2005
    Date of Patent: September 8, 2009
    Assignee: University of Kansas Medical Center
    Inventors: Opendra Narayan, Shilpa Buch
  • Patent number: 7488485
    Abstract: The present invention is directed to a DNA vaccine for immunization against HIV. The invention comprises a DNA molecule that has a sequence encoding a plurality of viral proteins capable of stimulating an immune response against HIV. The DNA molecule is rendered safe for use as a vaccine by the disruption of genes encoding reverse transcriptase, integrase, and Vif. The DNA molecule is further rendered safe by at least a partial deletion of the 3? LTR.
    Type: Grant
    Filed: September 15, 2004
    Date of Patent: February 10, 2009
    Assignee: University of Kansas Medical Center
    Inventors: Opendra Narayan, Zhenqian Liu
  • Publication number: 20070111958
    Abstract: A method of treating or preventing SHIV or HIV infection in a subject comprising administering a therapeutically effective amount of a antisense IL-4. The antisense IL-4 inhibits viral replication in the liver, lungs, spleen, and even the lymph nodes of the subject. Further, the antisense IL-4 can be used in combination with other antiretroviral agents or vaccines.
    Type: Application
    Filed: November 15, 2005
    Publication date: May 17, 2007
    Inventors: Opendra Narayan, Shilpa Buch
  • Publication number: 20070010471
    Abstract: A DNA vaccines or immunogenic composition for providing an immune response against HIV without exhibiting pathogenicity in the immunized individual because of the disruption of the ability of the DNA molecules to encode for viral proteins critical in producing pathogenicity. The DNA molecule is derived by passaging a SHIV in order to develop a SHIV that exhibits an increased replication efficiency and increased pathogenicity. Following passaging, the highly virulent SHIV virus is rendered safe by disrupting one or more genes, such as the rt, int, and vif genes, as well as the 3? LTR.
    Type: Application
    Filed: February 23, 2006
    Publication date: January 11, 2007
    Inventor: Opendra Narayan
  • Publication number: 20050112102
    Abstract: The present invention is directed to a DNA vaccine for immunization against HIV. The invention comprises a DNA molecule that has a sequence encoding a plurality of viral proteins capable of stimulating an immune response against HIV. The DNA molecule is rendered safe for use as a vaccine by the disruption of genes encoding reverse transcriptase, integrase, and Vif. The DNA molecule is further rendered safe by at least a partial deletion of the 3? LTR.
    Type: Application
    Filed: September 15, 2004
    Publication date: May 26, 2005
    Inventors: Opendra Narayan, Zhenqian Liu
  • Publication number: 20030220276
    Abstract: The present invention relates to a vaccine for immunization against HIV. The vaccine has DNA sequences encoding a plurality of viral proteins, including NEF, VPU and reverse transcriptase. The vaccine is rendered nonpathogenic by the disruption of the gene(s) encoding for at least one of these proteins.
    Type: Application
    Filed: October 24, 2002
    Publication date: November 27, 2003
    Inventor: Opendra Narayan
  • Patent number: 6060236
    Abstract: Borna disease virus (BDV) causes a rare neurological disease in horses and sheep. A subtractive cDNA expression library was constructed with poly A-selected RNA from a BDV infected MDCK cell line. A clone (B8) was isolated that specifically hybridizes to RNA isolated from BDV-infected brain tissue and BDV-infected cell lines. This clone hybridizes to four BDV-specific positive strand RNAs and one negative strand RNA in BDV-infected rat brain. Nucleotide sequence analysis of the clone suggests that it represents a full length mRNA which contains several open reading frames. The Borna Disease Virus DNA sequences as well as proteins encoded by the BDV DNA sequences are provided.
    Type: Grant
    Filed: December 29, 1998
    Date of Patent: May 9, 2000
    Assignee: The Johns Hopkins University School of Medicine
    Inventors: Janice E. Clements, Opendra Narayan, Susan Vandewoude, Juergen A. Richt
  • Patent number: 5854417
    Abstract: Borna disease virus (BDV) causes a rare neurological disease in horses and sheep. A subtractive cDNA expression library was constructed with poly A-selected RNA from a BDV Infected MDCK cell line. A clone (B8) was isolated that specifically hybridizes to RNA isolated from BDV-infected brain tissue and BDV-infected cell lines. This clone hybridizes to four BDV-specific positive strand RNAs and one negative strand RNA in BDV-infected rat brain. Nucleotide sequence analysis of the clone suggests that it represents a full length mRNA which contains several open reading frames. The Borna Disease Virus DNA sequences as well as proteins encoded by the BDV DNA sequences are provided.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: December 29, 1998
    Assignee: The Johns Hopkins University
    Inventors: Janice Clements, Opendra Narayan, Susan Vandewoude, Juergen Richt
  • Patent number: 5849994
    Abstract: HIV-1 does not cause disease in any non-human species. Thus, there is no animal model system to evaluate the efficacy of strategies aimed at preventing or ameliorating disease caused by this virus. The instant invention provides an animal model for HIV-1 induced disease, virus for generating such model animals, and methods for generating pathogenic SHIV.
    Type: Grant
    Filed: May 16, 1995
    Date of Patent: December 15, 1998
    Assignee: University of Kansas Medical Center
    Inventor: Opendra Narayan
  • Patent number: 5654401
    Abstract: Borna disease virus (BDV) causes a rare neurological disease in horses and sheep. A subtractive cDNA expression library was constructed with poly A-selected RNA from a BDV infected MDCK cell line. A clone (B8) was isolated that specifically hybridizes to RNA isolated from BDV-infected brain tissue and BDV-infected cell lines. This clone hybridizes to four BDV-specific positive strand RNAs and one negative strand RNA in BDV-infected rat brain. Nucleotide sequence analysis of the clone suggests that it represents a full length mRNA which contains several open reading frames. The Borna Disease Virus DNA sequences as well as proteins encoded by the BDV DNA sequences are provided.
    Type: Grant
    Filed: November 30, 1994
    Date of Patent: August 5, 1997
    Assignee: The Johns Hopkins University
    Inventors: Janice E. Clements, Opendra Narayan, Susan Vandewoude, Juergen A. Richt