Patents by Inventor Opendra Narayan
Opendra Narayan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20120207782Abstract: The present invention is directed to a DNA vaccine for immunization against HIV. The invention comprises a DNA molecule that has a sequence encoding a plurality of viral proteins capable of stimulating an immune response against HIV. The DNA molecule is rendered safe for use as a vaccine by the disruption of genes encoding reverse transcriptase, integrase, and Vif. The DNA molecule is further rendered safe by at least a partial deletion of the 3? LTR.Type: ApplicationFiled: July 18, 2011Publication date: August 16, 2012Applicants: University of Kansas Medical Center, National Institute for Agriculture ResearchInventors: Opendra Narayan, Euan Narayan, Yahia Chebloune
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Publication number: 20120020999Abstract: The present invention is directed to a DNA vaccine for immunization against HIV. The invention comprises a DNA molecule that has a sequence encoding a plurality of viral proteins capable of stimulating an immune response against HIV. The DNA molecule is rendered safe for use as a vaccine by the disruption of genes encoding reverse transcriptase, integrase, and Vif. The DNA molecule is further rendered safe by at least a partial deletion of the 3? LTR.Type: ApplicationFiled: July 18, 2011Publication date: January 26, 2012Applicant: UNIVERSITY OF KANSAS MEDICAL CENTERInventors: Opendra Narayan, Zhenqian Liu
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Publication number: 20120021000Abstract: The present invention is directed to a DNA vaccine for immunization against HIV. The invention comprises a DNA molecule that has a sequence encoding a plurality of viral proteins capable of stimulating an immune response against HIV. The DNA molecule is rendered safe for use as a vaccine by the disruption of genes encoding reverse transcriptase, integrase, and Vif. The DNA molecule is further rendered safe by at least a partial deletion of the 3? LTR.Type: ApplicationFiled: July 18, 2011Publication date: January 26, 2012Applicant: UNIVERSITY OF KANSAS MEDICAL CENTERInventors: Opendra Narayan, Zhenqian Liu
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Patent number: 8003113Abstract: The present invention is directed to a DNA vaccine for immunization against HIV. The invention comprises a DNA molecule that has a sequence encoding a plurality of viral proteins capable of stimulating an immune response against HIV. The DNA molecule is rendered safe for used as a vaccine by the disruption of genes encoding reverse transcriptase, integrase, and Vif. The DNA molecule is further rendered safe by at least a partial deletion of the 3? LTR.Type: GrantFiled: February 9, 2009Date of Patent: August 23, 2011Inventors: Opendra Narayan, Zhenqian Liu
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Publication number: 20100291143Abstract: A method of treating or preventing SHIV or HIV infection in a subject comprising administering a therapeutically effective amount of a antisense IL-4. The antisense IL-4 inhibits viral replication in the liver, lungs, spleen, and even the lymph nodes of the subject. Further, the antisense IL-4 can be used in combination with other antiretroviral agents or vaccines.Type: ApplicationFiled: June 10, 2009Publication date: November 18, 2010Applicant: UNIVERSITY OF KANSAS MEDICAL CENTERInventors: Opendra Narayan, Shilpa Buch
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Publication number: 20090233857Abstract: The present invention is directed to a DNA vaccine for immunization against HIV. The invention comprises a DNA molecule that has a sequence encoding a plurality of viral proteins capable of stimulating an immune response against HIV. The DNA molecule is rendered safe for used as a vaccine by the disruption of genes encoding reverse transcriptase, integrase, and Vif. The DNA molecule is further rendered safe by at least a partial deletion of the 3? LTR.Type: ApplicationFiled: February 9, 2009Publication date: September 17, 2009Applicant: University of Kansas Medical CenterInventors: Opendra Narayan, Zhenqian Liu
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Patent number: 7585675Abstract: A method of treating or preventing SHIV or HIV infection in a subject comprising administering a therapeutically effective amount of a antisense IL-4. The antisense IL-4 inhibits viral replication in the liver, lungs, spleen, and even the lymph nodes of the subject. Further, the antisense IL-4 can be used in combination with other antiretroviral agents or vaccines.Type: GrantFiled: November 15, 2005Date of Patent: September 8, 2009Assignee: University of Kansas Medical CenterInventors: Opendra Narayan, Shilpa Buch
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Patent number: 7488485Abstract: The present invention is directed to a DNA vaccine for immunization against HIV. The invention comprises a DNA molecule that has a sequence encoding a plurality of viral proteins capable of stimulating an immune response against HIV. The DNA molecule is rendered safe for use as a vaccine by the disruption of genes encoding reverse transcriptase, integrase, and Vif. The DNA molecule is further rendered safe by at least a partial deletion of the 3? LTR.Type: GrantFiled: September 15, 2004Date of Patent: February 10, 2009Assignee: University of Kansas Medical CenterInventors: Opendra Narayan, Zhenqian Liu
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Publication number: 20070111958Abstract: A method of treating or preventing SHIV or HIV infection in a subject comprising administering a therapeutically effective amount of a antisense IL-4. The antisense IL-4 inhibits viral replication in the liver, lungs, spleen, and even the lymph nodes of the subject. Further, the antisense IL-4 can be used in combination with other antiretroviral agents or vaccines.Type: ApplicationFiled: November 15, 2005Publication date: May 17, 2007Inventors: Opendra Narayan, Shilpa Buch
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Publication number: 20070010471Abstract: A DNA vaccines or immunogenic composition for providing an immune response against HIV without exhibiting pathogenicity in the immunized individual because of the disruption of the ability of the DNA molecules to encode for viral proteins critical in producing pathogenicity. The DNA molecule is derived by passaging a SHIV in order to develop a SHIV that exhibits an increased replication efficiency and increased pathogenicity. Following passaging, the highly virulent SHIV virus is rendered safe by disrupting one or more genes, such as the rt, int, and vif genes, as well as the 3? LTR.Type: ApplicationFiled: February 23, 2006Publication date: January 11, 2007Inventor: Opendra Narayan
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Publication number: 20050112102Abstract: The present invention is directed to a DNA vaccine for immunization against HIV. The invention comprises a DNA molecule that has a sequence encoding a plurality of viral proteins capable of stimulating an immune response against HIV. The DNA molecule is rendered safe for use as a vaccine by the disruption of genes encoding reverse transcriptase, integrase, and Vif. The DNA molecule is further rendered safe by at least a partial deletion of the 3? LTR.Type: ApplicationFiled: September 15, 2004Publication date: May 26, 2005Inventors: Opendra Narayan, Zhenqian Liu
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Publication number: 20030220276Abstract: The present invention relates to a vaccine for immunization against HIV. The vaccine has DNA sequences encoding a plurality of viral proteins, including NEF, VPU and reverse transcriptase. The vaccine is rendered nonpathogenic by the disruption of the gene(s) encoding for at least one of these proteins.Type: ApplicationFiled: October 24, 2002Publication date: November 27, 2003Inventor: Opendra Narayan
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Patent number: 6060236Abstract: Borna disease virus (BDV) causes a rare neurological disease in horses and sheep. A subtractive cDNA expression library was constructed with poly A-selected RNA from a BDV infected MDCK cell line. A clone (B8) was isolated that specifically hybridizes to RNA isolated from BDV-infected brain tissue and BDV-infected cell lines. This clone hybridizes to four BDV-specific positive strand RNAs and one negative strand RNA in BDV-infected rat brain. Nucleotide sequence analysis of the clone suggests that it represents a full length mRNA which contains several open reading frames. The Borna Disease Virus DNA sequences as well as proteins encoded by the BDV DNA sequences are provided.Type: GrantFiled: December 29, 1998Date of Patent: May 9, 2000Assignee: The Johns Hopkins University School of MedicineInventors: Janice E. Clements, Opendra Narayan, Susan Vandewoude, Juergen A. Richt
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Patent number: 5854417Abstract: Borna disease virus (BDV) causes a rare neurological disease in horses and sheep. A subtractive cDNA expression library was constructed with poly A-selected RNA from a BDV Infected MDCK cell line. A clone (B8) was isolated that specifically hybridizes to RNA isolated from BDV-infected brain tissue and BDV-infected cell lines. This clone hybridizes to four BDV-specific positive strand RNAs and one negative strand RNA in BDV-infected rat brain. Nucleotide sequence analysis of the clone suggests that it represents a full length mRNA which contains several open reading frames. The Borna Disease Virus DNA sequences as well as proteins encoded by the BDV DNA sequences are provided.Type: GrantFiled: May 31, 1995Date of Patent: December 29, 1998Assignee: The Johns Hopkins UniversityInventors: Janice Clements, Opendra Narayan, Susan Vandewoude, Juergen Richt
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Patent number: 5849994Abstract: HIV-1 does not cause disease in any non-human species. Thus, there is no animal model system to evaluate the efficacy of strategies aimed at preventing or ameliorating disease caused by this virus. The instant invention provides an animal model for HIV-1 induced disease, virus for generating such model animals, and methods for generating pathogenic SHIV.Type: GrantFiled: May 16, 1995Date of Patent: December 15, 1998Assignee: University of Kansas Medical CenterInventor: Opendra Narayan
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Patent number: 5654401Abstract: Borna disease virus (BDV) causes a rare neurological disease in horses and sheep. A subtractive cDNA expression library was constructed with poly A-selected RNA from a BDV infected MDCK cell line. A clone (B8) was isolated that specifically hybridizes to RNA isolated from BDV-infected brain tissue and BDV-infected cell lines. This clone hybridizes to four BDV-specific positive strand RNAs and one negative strand RNA in BDV-infected rat brain. Nucleotide sequence analysis of the clone suggests that it represents a full length mRNA which contains several open reading frames. The Borna Disease Virus DNA sequences as well as proteins encoded by the BDV DNA sequences are provided.Type: GrantFiled: November 30, 1994Date of Patent: August 5, 1997Assignee: The Johns Hopkins UniversityInventors: Janice E. Clements, Opendra Narayan, Susan Vandewoude, Juergen A. Richt