Patents by Inventor Ophir H. SHALEM

Ophir H. SHALEM has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • USE OF SRRD IN THE INHIBITION OF PROTEIN AGGREGATION
    Publication number: 20220227824
    Abstract: The present disclosure is directed to the use of SRR1 domain-containing protein (SRRD) or active fragment thereof to reduce protein aggregation, such as that occurring in neurodegenerative diseases.
    Type: Application
    Filed: June 23, 2020
    Publication date: July 21, 2022
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Ophir H. SHALEM, Katelyn SWEENEY
  • SCALABLE TAGGING OF ENDOGENOUS GENES BY HOMOLOGY-INDEPENDENT INTRON TARGETING
    Publication number: 20210180045
    Abstract: Provided herein are nucleic acid compositions and methods of their use for integrating reporter proteins, such as split fluorophore protein fragments, into intronic genomic regions. The integrated sequence is flanked by a splice acceptor site and a splice donor site such that the reporter protein sequence is incorporated into the mature mRNA expressed from the target gene.
    Type: Application
    Filed: September 3, 2019
    Publication date: June 17, 2021
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Ophir H. SHALEM, Yevgeniy V. SEREBRENIK, Stephanie E. SANSBURY