Abstract: The present invention provides compounds able to induce neuroprotection of damaged neurons and boost the remyelination potential of oligodendrocytes. The compounds have been identified through methods of pharmacological screening of a small molecule library consisting of known pharmacologically active compounds and approved drugs. The screening method is also included in the invention.

Abstract: A nasal implant delivery tool includes an inner handle, an outer handle, a needle, and a push rod. The inner handle includes a loading chamber configured to receive a nasal implant. The outer handle is configured to move axially relative to the inner handle. The needle extends distally from the inner handle and has a central lumen and a distal opening. The push rod is configured to move the nasal implant from the loading chamber, through the central lumen, and out the distal opening of the needle. The push rod is coupled to the outer handle such that the push rod moves axially relative to the inner handle when the outer handle is moved axially relative to the inner handle. Also described herein are nasal implant guides and methods of using nasal implant delivery tools and nasal implant guides.

Abstract: Methods for improving the gastrointestinal tolerability of biguanide compounds and for treating metabolic disorders and/or inducing weight loss in patients in need thereof, particularly in individuals having a contraindication for treatment with biguanide compounds, are provided comprising administering delayed release formulations of such biguanide compounds, including metformin, targeted to the small intestine.

Abstract: A method for fabricating semiconductor devices is disclosed. The method includes forming, on a first side of a substrate, a first stack and a second stack. The method includes etching, from the first side, a portion of the substrate interposed between the first and second stacks to form a recess. The method includes filling the recess with a dielectric material to form an isolation structure. The method includes forming, on the first side, one or more first interconnect structures over the first and second stacks. The method includes removing, from a second side of the substrate opposite to the first side, a remaining portion of the substrate. The method includes forming a via structure extending through at least the isolation structure. The method includes forming, on the second side, one or more second interconnect structures.

Abstract: A diagnostic tool and methods of using the tool are provided to quantify an amount of nasal collapse in a patient. The diagnostic tool includes a mask with an endoscope port and an opening to allow air flow, an endoscope with a camera adapted to take an image of the nasal valve, and an air flow sensor adapted to measure an inhalation rate of the patient. The diagnostic tool can quantify a size difference between the nasal valve during inhalation and zero flow by calculating a percentage difference in an area or one or more dimensions of the nasal valve during inhalation and zero flow.

Abstract: In an 802.11ax network with an access point, a trigger frame offers scheduled and random resource units to nodes for data uplink communication to the access point. To avoid the overall energy level seen by legacy nodes for a communication channel to drop below a detection threshold, the invention provides two tools. First, the scheduled and random resource units may be interleaved over communication channels. Second, unused resource units may be detected, and a node or the access point may send a padding signal on them to increase the overall energy level. The latter may be evaluated during a monitoring period before deciding to emit the signal. As the overall energy level seen by legacy nodes is increased, the risk that such legacy nodes do not detect activity on a 20 MHz channel having only a subpart of its RUs used is reduced. And risks of collisions are consequently reduced.

Abstract: A rotary engine comprised of a pair of counterrotating rotors within a non-rotating outer housing. Each of the rotors is coupled to a common power shaft, one directly and the other through a reversing gear arrangement. Both are driven by the hyper-expansion of combustion gases in a repeating combustion cycle. Each has a generally circular, nearly frictionless working surface perpendicular to the power shaft axis. Each rotor surface defines chambers which rotate past each other. Within such chambers, compressed air and fuel are introduced, mixed, ignited, allowed to hyper-expand (and thus cause the rotation) and exhausted. The power shaft may be connected to a conventional clutch, torque converter, gearbox, differential, alternator or a similar system.

Abstract: Provided are systems and methods enabling enrollment in promotions via a tokenization platform. In one example, the method may include establishing a network communication channel between a tokenization platform and a digital wallet of a user device, transmitting a promotion from the tokenization platform to the digital wallet on the user device via the established network communication channel, receiving authorization to accept the promotion at the tokenization platform from the digital wallet on the user device, and identifying tokenized payment account information of the digital wallet stored at the tokenization platform and automatically transmitting information about the tokenized payment account information of the digital wallet information from the tokenization platform to a promotion enrollment system associated with the promotion.

Abstract: Systems and methods for generating a video of a user-defined virtual reality scene are disclosed. Exemplary implementations may: obtain a scene definition; obtain camera information for multiple virtual cameras to be used in generating a two-dimensional presentation of the virtual reality scene; execute a simulation of the virtual reality scene from the scene definition for at least a portion of the scene duration; obtain camera timing instructions specifying which of the virtual cameras should be used to generate the two-dimensional presentation of the virtual reality scene as a function of progress through the scene duration; generate the two-dimensional presentation of the virtual reality scene in accordance with the camera timing instructions and the camera information.

Abstract: Devices, systems, and methods for releasing a catheter from an implant may include a catheter comprising first and second elongate elements, first and second elongate element lumens, a tissue anchor lumen, apertures corresponding to each of the lumens, and retaining portions between adjacent apertures. The first elongate element may extend out of its lumen through the first elongate element aperture, across the retaining portion transversely with respect to a longitudinal axis, and towards the second elongate element aperture. The first elongate element may then extend into the second elongate element aperture, loop over the second elongate element, and extend back across the retaining portion and into the first elongate element lumen. In some instances, the second elongate element is retracted to uncouple the first and second elongate elements from each other and to open a channel for the release of tethered tissue anchors.

Abstract: An apparatus for stoking a fire may include: at least one tube including a proximal region comprising a first aperture, a distal region comprising a second aperture, and hollow interior region connecting the first aperture and the second aperture, such that the first aperture and the second aperture are in fluid communication with each other; and a plate extending distally from the distal region of the tube, wherein the plate includes at least one fuel-engaging feature and a fluid-diverting region, wherein the fluid diverting region diverts fluid emitted from the second aperture, such that a path of the fluid changes.

Abstract: An example dehumidifier system may include one or more of a processor, an input display unit, a temperature and humidity censor configured to acquire current temperature and relative humidity data, an analog-to-digital transducer configured to convert, the acquired current temperature and relative humidity data from analog to digital output, a psychrometric converter module executed by the processor to convert the relative humidity data into ratio/absolute humidity data, a digital-to-analog transducer configured to convert the ratio/absolute humidity data into an analog format, a hysteresis comparator unit configured to compare hysteresis setpoint data received from the input display unit with data received from the temperature and humidity censor, and a ratio/absolute humidity setpoint comparator unit configured to compare a ratio/absolute humidity setpoint data received from the input display unit with the converted ratio/absolute humidity data.

Abstract: Systems and methods are provided for synchronizing messages. The systems and methods include operations for: identifying a difference between a current state of a messaging application and a shared synchronization database, wherein the shared synchronization database is updated via a third-party application in response to the third-party application receiving, from a server, a notification related to the messaging application, the messaging application and the third-party application being implemented on a client device; retrieving information from the shared synchronization database to update the current state of the messaging application based on the identified difference; and transmitting, to the server by the messaging application, a request for content based on the update to the current state of the messaging application.

Abstract: Systems and methods to reconfigure a scene based on timing and scene content are disclosed. Exemplary implementations may: obtain scene information defines a scene in which an event transpires; analyze the scene information that defines the event to identify effectual content and ineffectual content related to the event within the unedited event duration; and generate, based on the scene information and the analysis, a draft scene that includes an edited event comprising the effectual content from an edited event beginning to an edited event end in accordance with the prospective event duration.

Abstract: A diagnostic tool and methods of using the tool are provided to quantify an amount of nasal collapse in a patient. The diagnostic tool includes a mask with an endoscope port and an opening to allow air flow, an endoscope with a camera adapted to take an image of the nasal valve, and an air flow sensor adapted to measure an inhalation rate of the patient. The diagnostic tool can quantify a size difference between the nasal valve during inhalation and zero flow by calculating a percentage difference in an area or one or more dimensions of the nasal valve during inhalation and zero flow.

Abstract: The disclosure directed to a sandwich roll holder. The disclosure is further directed to a sandwich roll holder for use in warming, toasting, or heating sandwich rolls in proximity to a heat source, including toasting sandwich rolls over a barbeque. The sandwich roller holder may include collapsible elements that selectively receive one or more sandwich rolls while in an upright or extended position. The sandwich roll holder collapsible elements may also be configured to fold from the upright or extended position to a stowed position such that the sandwich roll holder may be conveniently stored or cleaned.

Abstract: The reaction of sodium hypochlorite with sodium bromide is slow, and commonly only part of the bromide is converted to hypobromite. Methods to accelerate the reaction by adding a regulated amount of acid to a solution comprising bleach and bromide are provided, whereby the yield of hypobromite can be increased. The amount of acid added can be predetermined based on the content of a base in the bleach, and acid can be added to neutralize the base. The amount of acid added can be based on a measured parameter of the reaction that is indicative of reaction kinetics. For example, the amount of acid can be actively controlled by measuring pH, absorbance of visible or near Ultraviolet light, or temperature of the reacting solution and adjusting acid.

Abstract: The disclosure relates to a formwork frame for a formwork element of a ceiling formwork, comprising: a first cross-support; a second cross-support; a connecting piece which is longer in comparison to the first and second cross-support, which is arranged substantially perpendicular to the first and second cross-support, and which connects the first cross-support to the second cross-support; a first lateral recess on the one longitudinal side of the formwork frame; and a second lateral recess on the other longitudinal side of the formwork frame.

Abstract: An internet service provider (ISP) is configured to analyze data sent by a user to determine a subscriber account associated with the data and a user associated with the data. A database is then queried to determine the number of users of the subscriber account, with a number above a threshold indicating a likely theft of service. This automatic process is accompanied by automated messaging to the user with information as to the measures taken and remedial options. The messaging may be different dependent on whether the user is deemed to be an authorized user having subscriber account administration rights.

Abstract: Embodiments described herein provide a process and method running on a computer for creating an augmented image. According to an embodiment, a graphical user interface gathers data that is programmatically analyzed to obtain photographic properties from a first image. Photographic properties are provided to a user for obtaining a second image containing a fiducial mark. The second image is programmatically analyzed to obtain photographic properties. The first image and the second image are programmatically analyzed and processed to produce an augmented image.