Abstract: The present disclosure describes compositions of matter comprising a ribonucleoprotein complex comprising a nucleic acid-guided nuclease and a guide RNA, and further comprising and a blocking nucleic acid molecule represented by Formula III in the 5?-to-3? direction comprises: T-D-M-A-(B-L)J-C; wherein T is 17-135 nucleotides in length; D is 0-10 nucleotides in length; M is 1-25 nucleotides in length or is absent, wherein if M is absent then T-D and A-(B-L)J-C are separate nucleic acid strands; A is 0-15 nucleotides in length and comprises at least 50% sequence complementarity to D; B is 4-12 nucleotides in length and comprises at least 50% sequence complementarity to T; L is 3-25 nucleotides in length; J is an integer between 1 and 10; C is 4-15 nucleotides in length; and wherein the blocking nucleic acid molecule comprises a sequence complementary to a gRNA.

Abstract: In an aspect, disclosed herein is a compound characterized by formula (FX1): A1-X1—X2-A2 (FX1); wherein: A1 is a carboxylic acid group, a carboxylate anion, or a carboxylate ester, X1 is a substituted or unsubstituted and saturated or unsaturated C1-C50 aliphatic group; X2 is a linker group selected from the group consisting of a direct bond, an organic group, -0-, —S—, —S(?O)—, —S(?O)2—, —S—S—, —N?, ?N—, —N(H)—, —N?N—N(H)—, —N(H)—N?N—, —N(OH)—, —N(?O)—, and any combination thereof; and A2 is a peptide, the peptide being terlipressin or a substituted or unsubstituted derivative, a substituted or unsubstituted natural or synthetic analogue, a substituted or unsubstituted variant, a substituted or unsubstituted isomer, or a substituted or unsubstituted fragment of terlipressin.

Abstract: In some implementations, a user device may present, on a user interface (UI) associated with a user account, a first UI element. The user device may detect a user interaction, with the user device, indicating the first UI element. The user device may present, on the UI and based on the user interaction, a second UI element, which increases in length in a first direction from a start point, along a closed path around the first UI element and ending at the start point, while the user interaction is being detected. The second UI element completes the closed path when an interaction duration satisfies a duration threshold, which indicates a confirmation of a request for an action associated with the user account. The duration threshold is based on one or more parameters associated with one or more of the action, the user account, or the user interaction.

Abstract: Methods, systems, and networks for controlling design and manufacture of mechanically and electrically compliant VCM-based vehicles, in which a user manually and explicitly defines at least one vehicle characteristic and at least one VCM characteristic. User selection of one or more vehicle characteristics ensures that the selection of VCM characteristics will be that of VCM characteristics compatible with the selected vehicle characteristics. Similarly, user selection of one or more VCMs or VCM characteristics ensures that the selection of vehicle characteristics will be that of vehicle characteristics compatible with the selected VCM or VCM characteristics.

Abstract: An ultrasonic transducer arrangement for a clamp-on ultrasonic, flow measuring point includes a plurality of ultrasonic transducers, each adapted to radiate ultrasonic signals into the measuring tube and/or to receive ultrasonic signals emerging from the measuring tube, wherein a first group of first ultrasonic transducers is arranged on a first side of the measuring tube, and a second group of second ultrasonic transducer is arranged on a second side of the measuring tube opposite the first side, wherein at least one first/second ultrasonic transducer is adapted to receive ultrasonic signals of at least one second/first ultrasonic transducer, respectively, wherein adjoining ultrasonic transducers of the first group have, in each case, first separations from one another, and wherein adjoining ultrasonic transducers of the second group have, in each case, second separations from one another.

Abstract: A keyboard for physically handicapped persons, including a translucent surface, a capacitive layer underneath the translucent surface, enabling detection of touch location and pressure on the translucent surface, a projection system dynamically projecting a plurality of visual layouts of keys of a keyboard on the translucent surface, wherein each visual layout includes ASCII character keys or graphical buttons, and a dynamic keyboard layout generator configured to receive user input in conformance with a currently projected layout of keys from a physically handicapped user, and to generate therefrom a time series of ASCII characters or button selections for input to the computing device, to dynamically adjust pressure sensitivity of the keyboard to avoid spurious user input, and to dynamically adjust key sizes and positions in a current virtual layout of keys, to reduce the amount of hand motion required by the user and the amount of discomfort experienced by the user.

Abstract: A training shoe includes a bottom sole, a midsole disposed above at least a portion of the bottom sole, one or more panels attached to one or both of the midsole and the bottom sole to define an enclosure for a person's foot, and a sidewall comprising a thermoplastic polyurethane (TPU). The sidewall may be disposed on at least a portion of the midsole and at least a portion of the one or more panels so as to define part of an external surface of the training shoe. The sidewall may extend upward past a bottom of the enclosure on either or both of an outer side of the training shoe and an inner side of the training shoe. The sidewall may extend from the outer side of the training shoe to the inner side of the training shoe along a rear of the training shoe.

Abstract: Compounds of formula (I), process for their production and their use as pharmaceuticals.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for organizing trained and untrained neural networks. In one aspect, a neural network device includes a collection of node assemblies interconnected by between-assembly links, each node assembly itself comprising a network of nodes interconnected by a plurality of within-assembly links, wherein each of the between-assembly links and the within-assembly links have an associated weight, each weight embodying a strength of connection between the nodes joined by the associated link, the nodes within each assembly being more likely to be connected to other nodes within that assembly than to be connected to nodes within others of the node assemblies.

Abstract: Provided herein are methods and systems for use with peristaltic pumps. More particularly, provided herein are peristaltic pump systems that include a dampener for reducing the pulsations of the flowrate from the peristaltic pump system to produce, mix, transfer and/or manufacture pharmaceutical compositions and formulations, including pharmaceutical compositions and formulations comprising lipids and RNA.

Abstract: An acoustic resonance device is provided including a cylindrical body, a tympanic cover, a vibration element, a lighting element, and a sensor. The cylindrical body includes an inner surface which defines a chamber. The chamber extends from a first end to a second end. The first end of the chamber is uncovered. The tympanic cover is coupled to the second end of the cylindrical body. The vibration element includes a first end and a second end. The first end of the vibration element is coupled to the tympanic cover. The lighting element is arranged within the chamber of the cylindrical body. The sensor is electrically coupled to the lighting element and is adapted to control the lighting element.

Abstract: An apparatus for remote controlled physical activity monitoring, the apparatus comprising: at least one orientation measurer, wearable on at least one body part of a user, configured to measure orientation of a body part wearing the orientation measurer during a physical activity of the user, at least one pressure meter, wearable on at least one body part of the user, configured to measure pressure applied by muscle of a body part wearing the pressure meter during the physical activity of the user, a computer processor, associated with the orientation measurer and pressure meter, configured to derive monitoring control data from the measured orientation and pressure, and a data transmitter, associated with the computer processor, configured to transmit the monitoring control data to a physical activity monitoring device, and thereby to remotely control a monitoring of the physical activity of the user by the physical activity monitoring device.

Abstract: An event query host can include an event processor configured to process an event stream indicating events that occurred on a computing device. The event processor can add representations of events to an event graph. If an event added to the event graph is a trigger event associated with a query, the event processor can also add an instance of the query to a query queue. The query queue can be sorted based on scheduled execution times of query instances. At a scheduled execution time of a query instance in the query queue, a query manager of the event query host can execute the query instance and attempt to find a corresponding pattern of one or more events in the event graph.

Abstract: A humidification system for a fuel cell system is provided, comprising a feed line for supplying cathode gas which is to be or is humidified, to a heat exchanger, further comprising a liquid supply and an eddy generator, located upstream of the liquid supply, for generating eddies in the flowing cathode gas. A fuel cell system comprising a humidification system is also provided.

Abstract: The present disclosure relates to an ultrasonic transducer arrangement of a clamp-on ultrasonic, flow measuring point having a plurality of clamp-on ultrasonic transducers, wherein the arrangement is configured to be applied on measuring tubes of various diameters, without necessitating new orienting of the ultrasonic transducers of the ultrasonic transducer arrangement.

Abstract: The present invention relates to a propylene polymer composition comprising a long chain branched propylene polymer, wherein said propylene polymer composition has a) a melt flow rate MFR2 (230° C., 2.16 kg) of 0.8 to 6.0 g/10 min b) a xylene hot insolubles (XHU) fraction in an amount of not more than 0.80 wt %, based on the total weight amount of the propylene polymer composition, c) a melting temperature Tm of at least 160.0° C., d) a F30 melt strength of from 5.0 to less than 30.0 cN, and e) a heat distortion temperature (HDT) of at least 108° C., a process for producing said propylene polymer composition by reactive modification of a propylene polymer in the presence of a peroxide, an article comprising said propylene polymer composition and the use of said propylene polymer composition for producing an article.

Abstract: A stemless implant for shoulder arthroplasty includes a body having a proximal portion, distal portion, and an outer surface. A cylindrical extrusion is substantially perpendicular to and adjacent the proximal portion. At least a portion of the outer surface is configured to contact bone, the outer bone contacting surface comprising a concave taper. The stemless implant can be sized and shaped for insertion into a metaphysis of a humerus bone without penetrating a diaphysis of the humerus bone. The implant optionally comprises a medial fin, a lateral fin, an anterior fin, and a posterior fin. The medial fin and lateral fin may be thicker than the anterior fin. The fins may taper from the proximal portion to the distal portion.

Abstract: The present disclosure relates generally to the treatment of patients with chronic graft-versus-host disease (cGVHD) following allogeneic hematopoietic stem cell transplantation by administering belumosudil at certain dosages.

Abstract: The present disclosure relates to systems and methods implemented on a memory controller for detecting and mitigating memory attacks (e.g., row hammer attacks). For example, a memory controller may track activations of row addresses within a memory hardware (e.g., a DRAM device) and determine whether a pattern of activations is indicative of a row hammer attack. This is determined using a counting mode for corresponding memory sub-banks. Where a likely row hammer attack is detected, the memory controller may activate a sampling mode (rather than the counting mode) for a particular sub-bank to identify which of the row addresses should be refreshed on the memory hardware. The implementations described herein provide a low computational cost alternative to heavy-handed detection mechanisms that require access to significant computing resources to accurately detect and mitigate row hammer attacks.

Abstract: To facilitate an efficient processing of contended cache lines, a cache controller that is associated with a requestor receives a fetch request for data from the requestor. The fetch request is associated with a cache scope designation. If the data is in a high-level cache (e.g., L1 cache) associated with the requestor, the cache controller returns the requested data to the requestor. If the data is not in the high-level cache or if the data is not within the cache pool identified by the cache scope of search designation, and/or if obtaining the data is contentious, the controller returns a cache miss, undeliverable data, and request done instruction to the requestor. Such scheme allows or permits address contention events when the requestor deems such events are necessary and/or when important. As such, address contention events, performance, latencies, increased executions times, inefficient use of resources, may be diminished.