Abstract: Disclosed are a series of furan fused ring-substituted glutarimide compounds and an application thereof in preparation of a drug for treating related diseases. In particular, disclosed is a compound represented by formula (II) or a pharmaceutically acceptable salt thereof.

Abstract: Provided herein are programmable nucleases and methods of genome editing and detection of nucleic acids with said programmable nuclease. In some embodiments, the programmable nuclease is a programmable nickase.

Abstract: Disclosed is an aminopyrimidine compound as a CDK2/4/6 inhibitor, and specifically disclosed are the compound represented by formula (I) and a pharmaceutically acceptable salt thereof, and an application of the compound represented by formula (I) and the pharmaceutically acceptable salt thereof in the preparation of a medicament for treating solid tumor.

Abstract: A spring-operated relief valve can include a main spring positioned between a bottom spring seat and a top spring seat. A seat assembly can include a valve seat, a seat retainer, and a spindle. The valve seat and the spindle can be received within an inner bore of the seat retainer and the spindle and the seat retainer can be threadably coupled. The valve seat can extend partially through the seat retainer to form a seal with a nozzle of the spring-operated relief valve and the spindle can engage the bottom spring seat to compress the main spring during a valve relief event.

Abstract: Disclosed herein are novel polyhydroxylated indolizidine and pyrrolizidine derivates and methods for using the same in the treatment of cancer. The present polyhydroxylated indolizidine and pyrrolizidine derivates has the structure of formula (I), wherein: X is O or b and c are independently an integral of 0 or and 1; R is selected from the group consisting of H, C1-6 alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, aralkyl, aralkenyl, aralkynyl, heteroaralkyl, heteroaralkenyl, beteroaralkynyl, heterocyclyl, alkoxy, aryloxy, and sulfonyl.

Abstract: A gantry motion platform includes a base, a first transmission mechanism, a second transmission mechanism and a working platform. The first transmission mechanism is mounted on the base and includes two first sliding rails, at least one first sliding block, and a first driving member. The first driving member is mounted on the base and located at a center position between the two first sliding rails. The second transmission mechanism is mounted on the at least one first sliding block and capable of moving along a first direction under driving of the first driving member. The working platform is mounted on the second transmission mechanism and capable of moving along the second direction under driving of a second transmission mechanism, and an angle is defined between the first direction and the second direction.

Abstract: Multispecific antibodies and antigen-binding fragments thereof that bind to human CEA and CD137, a pharmaceutical composition comprising said antibody, and use of the multispecific antibody or the composition for treating.

Abstract: The present disclosure provides an IL-10 variant protein, a fusion protein comprising the IL-10 variant protein and a polypeptide, and the use thereof. The present disclosure also provides a method of producing the same and a pharmaceutical composition comprising the same.

Abstract: The present disclosure provides a brake mechanism of a cart, a brake mechanism, a pedal structure, a drive member of a wheel structure, and a cart, wherein the drive member is arranged in the brake mechanism to be movable, wherein the drive member has a guiding side face, and the guiding side face is provided with a guiding slot including a stop slot; wherein the brake mechanism is also provided with a braking member, a stop end of the braking member is arranged to move in the guiding slot; wherein the drive member is provided with an anti-damage device, and the anti-damage device is arranged such that when a user tends to move the drive member in an incorrect direction, the anti-damage device is able to elastically obstruct or prevent the stop end from moving away from the stop slot in the first direction.

Abstract: A coated building article comprising a fiber cement cladding element may be coated with a system designed to achieve a desired appearance. The coating system may comprise a first coating layer and a second coating layer wherein the second coating layer comprises at least one layer of a low gloss coating composition which has a light reflectance of 5% or less when light is shone onto the surface of the coated article at an angle of 60° or 85° to the surface is positioned on at least a portion of the front face of the fiber cement cladding element. Also provided is a method of coating the building article with a low gloss coating composition.

Abstract: Example embodiments relate to an air cooling system for an electronic spinning assembly. An example embodiment includes a plurality of vanes coupled to a static base. A vane cover is rotatably coupled to the static base. The vane cover includes at least one air inlet, at least one air duct extending from the vane cover, and at least one choke point disposed in the cover. The at least one choke point is configured to increase a pressure of the airflow.

Abstract: This disclosure relates to the technical field of shoe material processing, and in particular to a method for processing a colored pattern on a shoe outsole material. The colored pattern is printed on a fiber membrane, and the membrane material printed with the colored pattern and a manufactured rubber shoe material are then placed in a compression mold to combine them totally to achieve good quality. This disclosure can make any design pattern without limitation and effectively avoid paint peeling off and color migration issues. Moreover, as the processing process is implemented by compression molding, it causes no pollution and is environment-friendly.

Abstract: A ceiling fan including a fan device and a remote control is provided. The fan device includes a motor and a control unit. The remote control includes a gesture sensing unit and a processing unit. The gesture sensing unit includes a sensing module that is configured to obtain a sense image of an object, and includes a storage medium that stores a plurality of data sets and different reference tracks that respectively correspond to the data sets. The processing unit is configured to: obtain a movement track of the object; obtain a corresponding one of the data sets when the movement track conforms with one of the reference tracks; and output a command that is related to said corresponding one of the data sets to the control unit. In response to receipt of the command, the control unit adjusts rotational speed of the motor according to the command.

Abstract: A high concentration antibody formulation comprising an antibody at a concentration of about 120-200 mg/ml, a histidine buffer at a concentration of about 5-15 mM, an amino acid at a concentration of about 1-1.5% (w/v), a tonicity modifier such as sodium chloride at a concentration of about 50-100 mM; and a non-ionic surfactant such as polysorbate 80 at a concentration of about 0.005-0.02% (w/v). In some instances, the high concentration antibody formulation may have a pH of about 5.5 to 6.5.

Abstract: A ceiling fan infrared detection and control system has a wall-mounted controller, a ceiling fan controller, and a motor. The wall-mounted controller has an infrared sensor that is arranged outwardly and horizontally. The wall-mounted controller is pivotally equipped with a lens outside the infrared sensor for detecting infrared rays of a human body within a detection range. The control unit can output a wireless signal to the ceiling fan controller to control the motor according to the infrared detection result. The ceiling fan infrared detection and control system uses the technical feature that the lens is rotatable relative to the wall-mounted controller, so that the detection range can be moved synchronously along with the lens. The detection range has directivity and the function of adjusting the detection position, which can avoid false detection of a pet below the height of the detection range.

Abstract: Systems and methods of harvesting wireless energy for climate control in a cabin of a vehicle are provided. The method comprises receiving an electromagnetic (EM) signal of EM radiation having EM energy to define an EM current. The method further comprises filtering the EM energy to regulate the EM current converting the EM current to direct current. The method further comprises storing the direct current for powering a battery-free wireless sensing unit and powering the battery-free wireless sensing unit with the direct current. After powering the battery-free wireless sensing unit, the method comprises sensing an actual condition in the cabin, the actual condition being one of actual temperature and actual humidity in the cabin. Furthermore, the method comprises adjusting one of temperature and humidity in the cabin in response to a difference between the actual condition and a set condition.

Abstract: Disclosed herein is a hydraulic brake with travel adjustment mechanism, comprising a brake body with a pressure cylinder; a piston rod extending through the pressure cylinder; a lever; a spring connected between the piston rod and the pressure cylinder; a brake hose connected to the other end of the brake body; a connecting rod, one end of which is connected to the lever, and the other end of which extends through the pressure cylinder to form a transmission engagement with the piston rod, a limiting component is arranged inside the pressure cylinder, and the limiting component acts on the connecting rod to restrict the connecting rod from leaving the pressure cylinder; an adjustable chamber is arranged in the connecting rod, and an adjustment element is provided inside the adjustable chamber, one end of which extends out of the adjustable chamber and forms a transmission engagement with the piston rod.

Abstract: Disclosed is a hybrid power system and an operation machinery. The hybrid power system includes an engine, a power distribution device, and a double-shaft extension motor. An input end of the power distribution device is connected to the output end of the engine, a first power output end of the power distribution device is connected to one end of the drive shaft, the input end is connected to the first power output end; a second power output end of the power distribution device is connected to one end of the double-shaft extension motor, and the second power output end is configured to selectively coupled with the input end or separated from the input end; another end of the double-shaft extension motor is configured to connect with the hydraulic power system.

Abstract: Aspects concern a method for predicting a path taken by a vehicle for a transport task comprising obtaining training data specifying paths taken, representing a set of valid paths as a Boolean formula, converting the Boolean formula into an OBBD[?] comprising, for each variable of a set of variables on which the Boolean formula operates, a decision node representing the variable, wherein the decision node has, for each assignment of a value to the variable represented by the decision node, an outgoing edge associated with the value, augmenting each outgoing edge of each decision node with a probability depending on the number of times the location represented by the decision node was visited in the paths specified by the training data elements and predicting a path for a given transport task by sampling an assignment of values to the variables by traversing the OBBD[?].

Abstract: While a voltage at a gate of one of a pair of series connected switches of a phase leg is greater than a threshold value, circuitry generates a signal with a logical value that precludes a gate driver corresponding to a gate of the other of the pair of series connected switches from driving the gate of the other of the pair of series connected switches.