Abstract: An implantable prosthetic device can include a radially expandable and compressible frame comprising a plurality of struts each comprising a first portion including one or more first segments and a second portion including one or more second segments, wherein the first segments are closer to an outflow end of the frame than the second segments, and a valvular structure mounted in the frame such that a majority of the volume is disposed in the portion of the frame comprising the second portions of the struts. The one or more first segments have a first width and the one or more second segments have a second width narrower than the first width.

Abstract: A method for cyber-security includes receiving an Executable and Linkable Format (ELF) file for analysis, and checking (i) whether the ELF file is corrupted and (ii) whether the ELF file is runnable by an Operating System (OS). Upon finding that the ELF file is corrupted but runnable by the OS, a decision is made that the ELF file is potentially malicious, and a responsive action is initiated.

Abstract: A method of managing blood flow involves providing a vascular implant device comprising a compliant tube, advancing the vascular implant device to a target location within a target blood vessel through a transcatheter access path, anchoring first and second end portions of the vascular implant device to the target blood vessel, at least a portion of the compliant tube being disposed between the first and second end portions, and resecting a portion of the target blood vessel around the at least a portion of the compliant tube.

Abstract: A system includes an annulus-marking device that comprises a two or more pull wires coupled to an expandable braided mesh. Pulling the pull wires can transition the braided mesh into a shape in which the mesh assumes (1) a sloped upper portion configured for positioning within an atrium of a heart of the subject, (2) a bulging ledge portion configured for positioning above the heart valve, and (3) a narrow portion for positioning within the heart valve. The system can also include an implant configured for placement along a native heart valve annulus of a subject. The implant can include a body portion comprising flexible material, the body portion having a longitudinal axis that runs along a length of the body portion. Other embodiments are also described.

Abstract: A tissue anchor includes a sharp tissue-engaging element and a driving interface which is fixed with respect to the tissue-engaging element. A tube has a blunt cap reversibly attached to and covering a distal end of the tube, and is transluminally advanceable in a distal direction toward an anatomical site within a subject. A driver, while engaged with the driving interface of the tissue anchor, is configured to drive the tissue-engaging element through the blunt cap and into tissue at the anatomical site, such that the blunt cap becomes an anchor-head of the tissue anchor, secured to the tissue by the tissue-engaging element. Other embodiments are also described.

Abstract: Apparatus, usable with a valve disposed between an atrium and a ventricle of a heart, the valve having a first leaflet (S) and at least one opposing leaflet (A,P). The apparatus comprises an augmenter (700) that comprises a flexible pouch (710) and an anchor (780). The pouch has an external surface, an interior, an outside, and a downstream opening that provides fluid communication between the interior and the outside of the pouch. The anchor is coupled to the pouch, and configured to anchor the pouch to the lip of the first leaflet by the anchor being anchored to the first leaflet. The anchoring is such that the downstream opening opens into the ventricle. Responsively to ventricular systole, the pouch inflates via the downstream opening, and the external surface coapts against the opposing leaflet(s).

Abstract: Disclosed are embodiments for facilitating automatic slice discovery and slice tuning for data mining in autonomous systems. In some aspects, an embodiment includes providing, by a processing device hosting a slice discovery machine learning (ML) model, input data to the slice discovery ML model, the input data corresponding to performance data of an autonomous vehicle (AV); identifying, by the slice discovery ML model, attributes of the AV and corresponding thresholds for the attributes that define a slice comprising a collection of data sharing common characteristics; and providing, by the slice discovery ML model, the attributes and the corresponding thresholds defining the slice to a slice miner to mine training data corresponding to the slice for a tailored dataset.

Abstract: A radiopaque frame is transluminally advanced to an atrium of a heart of a subject. The frame is expanded within a valve adjacent the atrium such that part of the frame remains disposed in the atrium. While the frame remains expanded within the valve, progressive portions of an annuloplasty structure are progressively positioned and anchored around the annulus using multiple anchors by, for each of the anchors sequentially (i) while fluoroscopically imaging the frame and a distal end of a delivery tool, and facilitated by mechanical guidance from the frame, positioning the distal end of the delivery tool between the frame and a wall of the atrium; and (ii) driving the anchor into the annulus laterally from the frame. Subsequently, the frame is contracted and withdrawn from the subject while leaving the annuloplasty structure anchored around the annulus. Other embodiments are also described.

Abstract: Disclosed are embodiments for facilitating automatic slice discovery and slice tuning for data mining in autonomous systems. In some aspects, an embodiment includes providing, by a processing device hosting a slice discovery machine learning (ML) model, input data to the slice discovery ML model, the input data corresponding to performance data of an autonomous vehicle (AV); identifying, by the slice discovery ML model, attributes of the AV and corresponding thresholds for the attributes that define a slice comprising a collection of data sharing common characteristics; and providing, by the slice discovery ML model, the attributes and the corresponding thresholds defining the slice to a slice miner to mine training data corresponding to the slice for a tailored dataset.

Abstract: Disclosed are embodiments for facilitating autonomous vehicle (AV) pullover clustering prevention. In some aspects, an embodiment includes receiving identification of an origin location and a destination location corresponding to a transportation trip request for an AV; determining a set of pullover locations comprising pickup locations for the origin location and drop-off locations for the destination location; for each pullover location of the set of pullover locations: determining an estimated time of arrival (ETA) time window for the AV at the pullover location; determining a number of other AVs expected to be at the pullover location during the ETA time window; and responsive to the number of other AVs expected to be at the pullover location during the ETA time window exceeding an AV pullover crowding metric, removing the pullover location from the set of pullover locations to produce a revised set of pullover locations.

Abstract: A heart valve tissue cutting device includes a housing formed with an elongate opening, a cutting guide arm pivoted to the housing by a hinge assembly, and a cutting element including a cutting blade and a stabbing element. The cutting guide arm is formed with a guide slot. The cutting element is arranged to move on a track structure in the housing. A sharp pointed end of the stabbing element is tilted with respect to the cutting blade and points towards the cutting guide arm. The cutting blade is arranged, when in a deployed position, to pass through the guide slot.

Abstract: A walking path database stores data describing a set of connected walking paths. The walking path database may be generated based on an existing map database describing connected roads. The walking path database and map database are used to generate a combined walking and driving route, where a user walks to a particular pickup location, and a vehicle drives the user from the pickup location to a particular destination. The combined walking and driving route may be a route that minimizes the overall trip time.

Abstract: Vehicles detect temporary traffic restrictions and provide information describing the traffic restrictions to a remote computer system. The remote computer system can determine a routing cost for the traffic restriction and alert other vehicles in a fleet of vehicles about the traffic restrictions. The other vehicles can account for the routing cost when determining a route to follow; the route may avoid the traffic restriction. Vehicles in the fleet, when driving near a particular traffic restriction, may perceive the area where the traffic restriction was detected and provide updates about the traffic restriction, e.g., whether the boundaries of the TTR have changed (e.g., a construction area or emergency response has expanded or moved), or the TTR has been removed (e.g., a construction area has reopened, or a stopped vehicle has left the roadway).

Abstract: Tensioning devices are described that include a handle, a line carriage configured to be coupled to a tensioning line, and an electrical motor assembly configured to axially translate the tensioning line relative to the handle to thereby modify a tension in the tensioning line. Other implementations are also described, including a tensioning device including a handle, a line carriage configured to be coupled to a tensioning line, and a manually-manipulatable actuator configured to be selectively transitioned between a fine-tensioning configuration and a gross-tensioning configuration.

Abstract: A tissue anchor includes a tissue-engaging element, a head, and a protrusion. The tissue-engaging element has a sharpened distal tip, and is configured to be driven into tissue of a subject. The head is coupled to a proximal end of the tissue-engaging element, and includes a driver interface that is configured to be reversibly engaged by an anchor driver. The protrusion protrudes away from the head such that driving the tissue-engaging element into the tissue presses the protrusion against the tissue, and is configured to move with respect to the head automatically in response to being pressed against the tissue. Other embodiments are also described.

Abstract: A catheter device includes a tube that has a distal opening that is configured to be transluminally advanced into the subject; and an extracorporeal unit that is coupled to a proximal end of the tube. A series of cartridges is arranged along the extracorporeal unit, each of the cartridges having an initial position in which the cartridge holds a respective anchor. Each of the cartridges is, moveable from the initial position to a deployment position while remaining coupled to the extracorporeal unit. A driver is configured to, for each of the anchors, sequentially, while the respective cartridge is in the deployment position, move the anchor out of the respective cartridge and through the tube toward the distal opening. Other embodiments are also described.

Abstract: A method for grouping prosthetic valve leaflets of an aggregate of prosthetic valve leaflets is provided. Using a computer processor, for each leaflet of the aggregate, a leaflet-flexibility value is derived. A group size value is provided to the processor. Using the processor, at least some of the leaflets of the aggregate are designated into leaflet groups, based on similarity between the respective leaflet-flexibility value of each leaflet of the aggregate. Each of the leaflet groups includes a number of leaflets equal to the group size value. Using the processor, an indication of the designated leaflet groups is outputted. Other embodiments are also described.

Abstract: An implant comprises a leaflet-augmentation patch, a patch anchor, and a cord. The patch comprises a flexible sheet, and a frame that supports the flexible sheet. The frame defines a spring configured to tension the cord. The cord couples the patch anchor to the patch in a manner in which anchoring the patch anchor to a first leaflet of a heart valve of a subject positions the patch to coapt with a second leaflet of the valve during ventricular systole. Other embodiments are also described.

Abstract: Apparatus comprising a tissue anchor for use with an anchor driver. The anchor comprises a head, and a tissue-engaging element coupled to a proximal end of the head. The tissue-engaging element defines a central longitudinal axis of the anchor, and has a sharpened distal tip, configured to be driven into tissue of a subject. The head comprises a driver interface, configured to be reversibly engaged by the anchor driver, and an eyelet, disposed laterally from the central longitudinal axis, defining an aperture on an aperture plane, the aperture having a length along a long axis of the aperture and a width along a short axis of the aperture, the long axis and the short axis disposed on the aperture plane. The eyelet is mounted such that the aperture plane is slanted at a fixed angle with respect to the central longitudinal axis. Other applications are also described.

Abstract: A method for grouping prosthetic valve leaflets of an aggregate of prosthetic valve leaflets is provided. Using a computer processor, for each leaflet of the aggregate, in response to an image parameter of the leaflet, a leaflet-flexibility value is derived. A group size value is provided to the processor. Using the processor, at least some of the leaflets of the aggregate are designated into leaflet groups, based on similarity between the respective leaflet-flexibility value of each leaflet of the aggregate. Each of the leaflet groups includes a number of leaflets equal to the group size value. Using the processor, an indication of the designated leaflet groups is outputted. Other embodiments are also described.