Abstract: A radiopaque frame is transluminally advanced to an atrium of a heart of a subject. The frame is expanded within a valve adjacent the atrium such that part of the frame remains disposed in the atrium. While the frame remains expanded within the valve, progressive portions of an annuloplasty structure are progressively positioned and anchored around the annulus using multiple anchors by, for each of the anchors sequentially (i) while fluoroscopically imaging the frame and a distal end of a delivery tool, and facilitated by mechanical guidance from the frame, positioning the distal end of the delivery tool between the frame and a wall of the atrium; and (ii) driving the anchor into the annulus laterally from the frame. Subsequently, the frame is contracted and withdrawn from the subject while leaving the annuloplasty structure anchored around the annulus. Other embodiments are also described.

Abstract: Disclosed are embodiments for facilitating automatic slice discovery and slice tuning for data mining in autonomous systems. In some aspects, an embodiment includes providing, by a processing device hosting a slice discovery machine learning (ML) model, input data to the slice discovery ML model, the input data corresponding to performance data of an autonomous vehicle (AV); identifying, by the slice discovery ML model, attributes of the AV and corresponding thresholds for the attributes that define a slice comprising a collection of data sharing common characteristics; and providing, by the slice discovery ML model, the attributes and the corresponding thresholds defining the slice to a slice miner to mine training data corresponding to the slice for a tailored dataset.

Abstract: Disclosed are embodiments for facilitating autonomous vehicle (AV) pullover clustering prevention. In some aspects, an embodiment includes receiving identification of an origin location and a destination location corresponding to a transportation trip request for an AV; determining a set of pullover locations comprising pickup locations for the origin location and drop-off locations for the destination location; for each pullover location of the set of pullover locations: determining an estimated time of arrival (ETA) time window for the AV at the pullover location; determining a number of other AVs expected to be at the pullover location during the ETA time window; and responsive to the number of other AVs expected to be at the pullover location during the ETA time window exceeding an AV pullover crowding metric, removing the pullover location from the set of pullover locations to produce a revised set of pullover locations.

Abstract: A heart valve tissue cutting device includes a housing formed with an elongate opening, a cutting guide arm pivoted to the housing by a hinge assembly, and a cutting element including a cutting blade and a stabbing element. The cutting guide arm is formed with a guide slot. The cutting element is arranged to move on a track structure in the housing. A sharp pointed end of the stabbing element is tilted with respect to the cutting blade and points towards the cutting guide arm. The cutting blade is arranged, when in a deployed position, to pass through the guide slot.

Abstract: Tensioning devices are described that include a handle, a line carriage configured to be coupled to a tensioning line, and an electrical motor assembly configured to axially translate the tensioning line relative to the handle to thereby modify a tension in the tensioning line. Other implementations are also described, including a tensioning device including a handle, a line carriage configured to be coupled to a tensioning line, and a manually-manipulatable actuator configured to be selectively transitioned between a fine-tensioning configuration and a gross-tensioning configuration.

Abstract: A tissue anchor includes a tissue-engaging element, a head, and a protrusion. The tissue-engaging element has a sharpened distal tip, and is configured to be driven into tissue of a subject. The head is coupled to a proximal end of the tissue-engaging element, and includes a driver interface that is configured to be reversibly engaged by an anchor driver. The protrusion protrudes away from the head such that driving the tissue-engaging element into the tissue presses the protrusion against the tissue, and is configured to move with respect to the head automatically in response to being pressed against the tissue. Other embodiments are also described.

Abstract: A catheter device includes a tube that has a distal opening that is configured to be transluminally advanced into the subject; and an extracorporeal unit that is coupled to a proximal end of the tube. A series of cartridges is arranged along the extracorporeal unit, each of the cartridges having an initial position in which the cartridge holds a respective anchor. Each of the cartridges is, moveable from the initial position to a deployment position while remaining coupled to the extracorporeal unit. A driver is configured to, for each of the anchors, sequentially, while the respective cartridge is in the deployment position, move the anchor out of the respective cartridge and through the tube toward the distal opening. Other embodiments are also described.

Abstract: A method for grouping prosthetic valve leaflets of an aggregate of prosthetic valve leaflets is provided. Using a computer processor, for each leaflet of the aggregate, a leaflet-flexibility value is derived. A group size value is provided to the processor. Using the processor, at least some of the leaflets of the aggregate are designated into leaflet groups, based on similarity between the respective leaflet-flexibility value of each leaflet of the aggregate. Each of the leaflet groups includes a number of leaflets equal to the group size value. Using the processor, an indication of the designated leaflet groups is outputted. Other embodiments are also described.

Abstract: An implant comprises a leaflet-augmentation patch, a patch anchor, and a cord. The patch comprises a flexible sheet, and a frame that supports the flexible sheet. The frame defines a spring configured to tension the cord. The cord couples the patch anchor to the patch in a manner in which anchoring the patch anchor to a first leaflet of a heart valve of a subject positions the patch to coapt with a second leaflet of the valve during ventricular systole. Other embodiments are also described.

Abstract: Apparatus comprising a tissue anchor for use with an anchor driver. The anchor comprises a head, and a tissue-engaging element coupled to a proximal end of the head. The tissue-engaging element defines a central longitudinal axis of the anchor, and has a sharpened distal tip, configured to be driven into tissue of a subject. The head comprises a driver interface, configured to be reversibly engaged by the anchor driver, and an eyelet, disposed laterally from the central longitudinal axis, defining an aperture on an aperture plane, the aperture having a length along a long axis of the aperture and a width along a short axis of the aperture, the long axis and the short axis disposed on the aperture plane. The eyelet is mounted such that the aperture plane is slanted at a fixed angle with respect to the central longitudinal axis. Other applications are also described.

Abstract: A method for grouping prosthetic valve leaflets of an aggregate of prosthetic valve leaflets is provided. Using a computer processor, for each leaflet of the aggregate, in response to an image parameter of the leaflet, a leaflet-flexibility value is derived. A group size value is provided to the processor. Using the processor, at least some of the leaflets of the aggregate are designated into leaflet groups, based on similarity between the respective leaflet-flexibility value of each leaflet of the aggregate. Each of the leaflet groups includes a number of leaflets equal to the group size value. Using the processor, an indication of the designated leaflet groups is outputted. Other embodiments are also described.

Abstract: Security Information and Event Management tools, log management tools, log analysis tools, and other event data management tools are enhanced. Enhancements harvest entity extraction rules from queries, query results, and other examples involving the extraction of field values from large amounts of data, and help perform entity extraction efficiently. Entity extraction operations locate IP addresses, usernames, and other field values that are embedded in logs or data streams, for example, and populate object properties with extracted values. Previously used extraction rules are applied in new contexts with different users, different data sources, or both. An entity extraction rules database serves as a model that contains rules specifying parsing mechanisms. Parsing mechanisms may include regular expressions, separation character definitions, and may process particular file formats or object notation formats or markup language formats.

Abstract: An assembly (10) for crimping a frame (56) of an implant (58) comprises a crimping device (20) with a base (22) and a crimping mechanism (24) that defines a crimping aperture (26). A bath (28) having a floor (30), and one or more side-walls (32) extending upward from the floor to a side-wall height defines a receptacle (18) that is shaped to receive a portion of the crimping device. The apparatus has an assembled state in which the portion of the crimping device has been received by the receptacle, the crimping device is held securely by the bath, and the aperture is below the side-wall height. Other embodiments are also described.

Abstract: A delivery system includes a handle, a catheter shaft, and a steering mechanism. The catheter shaft extends from the handle to a flexible distal end portion. The steering mechanism is configured to steer the flexible distal end portion. The steering mechanism can include a steering element a control member, and one or more actuation elements. Actuating the control member can move the steering element to increase and/or decrease tension in one or more actuation elements.

Abstract: A method of using a computer processor for grouping prosthetic valve leaflets of an aggregate of prosthetic valve leaflets is provided. For each leaflet of the aggregate, in response to an image parameter of the leaflet, a leaflet-flexibility value is derived. At least some of the leaflets of the aggregate are designated into leaflet groups, based on similarity between the respective leaflet-flexibility value of each leaflet of the aggregate. For each of the designated leaflet groups, the flexibility value of each leaflet in the designated leaflet group is within the intra-group tolerance with respect to the leaflet-flexibility value of each other leaflet in the designated leaflet group. An indication of the designated leaflet groups is outputted. Other embodiments are also described.

Abstract: A radiopaque frame is transluminally advanced to an atrium of a heart of a subject. The frame is expanded within a valve adjacent the atrium such that part of the frame remains disposed in the atrium. While the frame remains expanded within the valve, progressive portions of an annuloplasty structure are progressively positioned and anchored around the annulus using multiple anchors by, for each of the anchors sequentially (i) while fluoroscopically imaging the frame and a distal end of a delivery tool, and facilitated by mechanical guidance from the frame, positioning the distal end of the delivery tool between the frame and a wall of the atrium; and (ii) driving the anchor into the annulus laterally from the frame. Subsequently, the frame is contracted and withdrawn from the subject while leaving the annuloplasty structure anchored around the annulus. Other embodiments are also described.

Abstract: A method of using a computer processor for grouping prosthetic valve leaflets of an aggregate of prosthetic valve leaflets is provided. For each leaflet of the aggregate, in response to an image parameter of the leaflet, a leaflet-flexibility value is derived. At least some of the leaflets of the aggregate are designated into leaflet groups, based on similarity between the respective leaflet-flexibility value of each leaflet of the aggregate. For each of the designated leaflet groups, the flexibility value of each leaflet in the designated leaflet group is within the intra-group tolerance with respect to the leaflet-flexibility value of each other leaflet in the designated leaflet group. An indication of the designated leaflet groups is outputted. Other embodiments are also described.

Abstract: A method for grouping prosthetic valve leaflets of an aggregate of prosthetic valve leaflets is provided. Using a computer processor, for each leaflet of the aggregate, in response to an image parameter of the leaflet, a leaflet-flexibility value is derived. A group size value is provided to the processor. Using the processor, at least some of the leaflets of the aggregate are designated into leaflet groups, based on similarity between the respective leaflet-flexibility value of each leaflet of the aggregate. Each of the leaflet groups includes a number of leaflets equal to the group size value. Using the processor, an indication of the designated leaflet groups is outputted. Other embodiments are also described.

Abstract: Apparatus comprising a tissue anchor for use with an anchor driver. The anchor comprises a head, and a tissue-engaging element coupled to a proximal end of the head. The tissue-engaging element defines a central longitudinal axis of the anchor, and has a sharpened distal tip, configured to be driven into tissue of a subject. The head comprises a driver interface, configured to be reversibly engaged by the anchor driver, and an eyelet, disposed laterally from the central longitudinal axis, defining an aperture on an aperture plane, the aperture having a length along a long axis of the aperture and a width along a short axis of the aperture, the long axis and the short axis disposed on the aperture plane. The eyelet is mounted such that the aperture plane is slanted at a fixed angle with respect to the central longitudinal axis. Other applications are also described.

Abstract: A method for grouping prosthetic valve leaflets of an aggregate of prosthetic valve leaflets is provided. Using a computer processor, for each leaflet of the aggregate, in response to an image parameter of the leaflet, a leaflet-flexibility value is derived. A group size value is provided to the processor. Using the processor, at least some of the leaflets of the aggregate are designated into leaflet groups, based on similarity between the respective leaflet-flexibility value of each leaflet of the aggregate. Each of the leaflet groups includes a number of leaflets equal to the group size value. Using the processor, an indication of the designated leaflet groups is outputted. Other embodiments are also described.