Abstract: Disclosed is a proteolipid vesicle (PLV) for delivering a therapeutic cargo, such as nucleic acids, polypeptides and molecules, to a cell, the proteolipid vesicle having a lipid nanoparticle comprising one or more ionizable lipids and one or more of a fusion associated small transmembrane (FAST) family of proteins and chimerics thereof, where the molar ratio of ionizable lipid to therapeutic cargo is between 2.5:1 and 20:1. Incorporation of a chimeric FAST protein into a PLV platform enhances intracellular delivery and expression of mRNA and pDNA both in vitro and in vivo. These PLVs also display a favorable immune profile and are significantly less toxic than conventional LNPs.

Abstract: An electrical insulated threaded connection includes a conductive box with a plurality of internal threads, a conductive pin with a plurality of external threads, and a double-threaded electrical insulator sleeve disposed between the conductive pin and box. The double-threaded electrical insulator sleeve comprises a plurality of external threads that mate with the plurality of internal threads of the conductive box and a plurality of internal threads that mate with the plurality of external threads of the conductive pin. In certain embodiments, the double-threaded electrical insulator sleeve fills a full volume between the plurality of internal threads of the conductive box and the plurality of external threads of the conductive pin, and there are no voids or pockets between any of the mating threads.

Abstract: A capacitive memory cell includes an electrode, a tunneling barrier layer in direct contact with the electrode, a charge trapping layer in direct contact with the tunneling barrier layer, a ferroelectric layer in direct contact with the charge trapping layer, and another electrode in direct contact with the ferroelectric layer.

Abstract: Methods, apparatus, and processor-readable storage media for generating and processing digital asset information chains using machine learning techniques are provided herein. An example computer-implemented method includes obtaining data, from one or more data sources, pertaining to one or more events involving a digital asset; generating a digital asset information chain associated with the digital asset by processing at least a portion of the obtained data using at least one cryptographic function and linking that at least a portion of the obtained data in accordance with at least one temporal parameter; performing anomaly detection by processing at least a portion of the digital asset information chain associated with the digital asset using one or more machine learning techniques; and performing one or more automated actions based at least in part on one or more of the digital asset information chain and results from the anomaly detection.

Abstract: Apparatus and methods of managing a virtual area based on communicant capabilities are described. The communicant capabilities are updated based on rules in response to events in the virtual area. An action by one communicant can affect the capabilities of another communicant. Communicant capabilities can be stored in respective server-side proxies and the virtual area can be managed without transmitting any of the capabilities to the communicants' client network nodes. Capability-based permissions checks can be performed against communicant capabilities with wildcarded attribute fields.

Abstract: A computer implemented method for securely sharing underlying data of a data owner to a data recipient is disclosed.

Abstract: A wind turbine control system and method, for the type of wind turbines includes a rotor, an asynchronous generator driven by the rotor and configured for providing an active power to a grid, and a power converter connected to the generator and configured to interact with the generator for generating the required active power for the grid. The control system includes a converter control unit for controlling the power converter and for estimating a frequency derivative of the frequency of the grid, and a wind turbine controller configured for receiving the estimated frequency derivative and for considering the received frequency derivative for determining a synthetic inertia. The converter control unit controls the power converter to cause the generator to also provide the synthetic inertia, in the form of active power.

Abstract: Described herein are compounds that are autotaxin inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with autotaxin activity.

Abstract: The invention generally relates to systems and methods for improving sleep by treating at least one of rhinitis, congestion, and/or rhinorrhea to thereby reduce or eliminate symptoms associated therewith, including, but not limited to, nasal congestion, coughing, sneezing, and nasal or throat irritation and itching.

Abstract: A toilet seat assembly includes a toilet seat that includes an inner rim and a contoured upper seat surface; and a lid hinged to the toilet seat and movable between an open lid position and a closed lid position; wherein the lid includes an inner liner that includes a shaped surface portion and a core portion, the shaped surface portion is shaped to correspond to the contoured upper seat surface of the toilet seat, and the core portion is joined to the shaped surface portion at the inner rim of the toilet seat, and in the closed lid position the shaped surface portion of the lid covers the upper seat surface of the toilet seat, and the core portion of the lid covers the central opening of the toilet seat and extends down past an upper edge of the inner rim.

Abstract: Systems, methods, and devices for sacroiliac joint fusion described include an implant comprising a first body having a distal anchor and a second body having proximal anchor. The first body includes a threaded body integrally formed with the first body or threadably coupled to the first body. The distal anchor may be formed by a pair of deployable wings. The pair of deployable wings may be deployed within the cancellous bone of the sacrum and anchored against the cortical bone of the sacrum. The proximal anchor may engage with an outer surface of the ilium. The second body may be threaded along the threaded body to provide compression across the sacroiliac joint. Compressing the sacroiliac joint can reduce motion thereof to promote fusion and stabilization.

Abstract: A system and method for deterring the theft of a marine battery pack used to power a marine propulsion system, such as an outboard motor. The marine battery pack includes an internal communication system that allows the battery pack to communicate with an authentication device. The battery pack communicates an authentication request to the authentication device. If the battery pack is associated with the authentication device, a confirmation is communicated to the marine battery pack and the marine battery pack operates in a normal manner. If confirmation is not received from an authentication device, the operation of the marine battery pack is modified from the normal condition. The modification of the operation of the battery pack renders the battery pack unusable to deter theft. Each battery pack may be associated with more than one authentication device and each authentication device may be associated with more than one battery pack.

Abstract: A casing packer apparatus (P) comprising a mandrel (2) having a longitudinal throughbore, a packer element (6) mounted on the mandrel, and an expansion mechanism comprising a piston (11, 12) configured to move the packer element from a first position radially outwards to a second position. A bypass conduit (25) extends generally in said longitudinal direction, from one side of an outer sealing face of the packer element to an opposite side of the outer sealing face, and a bypass valve (41) controls said bypass conduit. The bypass valve is controlled by signals received via a wireless receiver (40). The casing packer can be deployed as an integral part of the casing string and used to control pressure build-up in the casing annulus.

Abstract: A method, detection assay, and kit for rapidly detecting mutations of the SARS-COV-2 virus includes preparing a detection assay, performing an asymmetric real time-polymerase chain reaction (RT-PCR) on the detection assay using a Mic Real Time PCR cycler, and analyzing a melting curve to detect peaks at a 484 and a 501 codon of a gene, or detect peaks at a 452 codon and a 478 codon of a gene. The method, detection assay, and kit also provides for detecting of the SARS-COV-2 virus and mutations thereof. Disclosed is a high-throughput test that can detect multiple variants of the SARS-COV-2 virus within two-and-a-half hours, and is a major advance in tracking the virus and in treating patients. The test can detect UK, Brazil, South African, and Omicron variants, as well as others containing, for example, a key E484K mutation, which are gaining prominence as the virus evolves.

Abstract: At least one example embodiment relates to a chewing gum. In at least one example embodiment, the chewing gum comprises a gum base polymer and oil. The gum base polymer includes polyvinyl acetate (PVA) in an amount ranging from 35 weight percent to 55 weight percent of the chewing gum. The oil is present in an amount greater than 8 weight percent of the chewing gum. The oil includes a triglyceride, triacetin, and nicotine or a nicotine derivative. The triglyceride is present in an amount greater than or equal to 5 weight percent of the chewing gum. At least one example embodiment relates to a method of preparing a controlled-release nicotine chewing gum.

Abstract: A pier for a solar tracking system includes a bearing housing assembly, a frame, the frame defining an A-profile having a pair of legs and a crown at a center portion thereof, and a mounting bracket, the mounting bracket coupled to a portion of the crown of the frame at a first portion thereof and coupled to a portion of the bearing housing assembly at a second portion thereof.

Abstract: A food composition capable of maintaining a crunchy texture after freezing and reheating is disclosed. The food composition includes a crust or an outer casing having a dough-based matrix or a batter-based matrix with a thickness of about 2 to about 150 mm, and texture modifying particles dispersed throughout the matrix. The texture modifying particles generally comprise about 12 to about 40% by weight of the food composition and provide the food composition with a crunchy texture. The texture modifying particles may be crushed particles of food products, such as fried grain chips, fried vegetable chips, extruded cereals, extruded crackers, or combinations thereof.

Abstract: The subject technology enables encryption key distribution when a processor is in offline mode. When offline, key distribution servers can distribute private/public key pairs in place of the processor. The servers can distribute a public key to a user device for encryption of data. The encrypted data can be provided to the processor, which can return a token in response to provide to the first server.

Abstract: Methods, systems, apparatuses, and computer program products are provided herein for determining the handedness of input provided by a user via a touch interface. For instance, for each touch-based input detected, a score indicating a probability whether the touch-based input was inputted by a particular hand of the user is generated. A classification for the touch-based input is then generated based on a drift diffusion model-based technique in which inter-dependencies between a series of touch-based input are approximated. The determined classifications are used to determine the handedness of the user.

Abstract: Disclosed herein is a network management apparatus, comprising: a change request acquisition unit configured to acquire a change request that describes information on contents of a change plan relating to a network configuration; a first determination unit configured to determine, based on the information included in the change request, whether or not to perform an automatic approval that approves the change request without notifying an approver of the change request; a risk assessment unit configured to assess, based on the information included in the change request, a risk of implementing a change in accordance with the change request; and a second determination unit configured to determine whether or not to perform the automatic approval based on the risk assessed by the risk assessment unit with respect to the change request for which the automatic approval has not been determined to be performed by the first determination unit.