Abstract: The present invention relates generally to immunization and immunotherapy for the treatment or prevention of HIV. In particular, the methods include in vivo and/or ex vivo enrichment of HIV-specific CD4+ T cells.

Abstract: Apparatus and associated methods relate to a singular event notification system (SENS). In an illustrative example, the SENS may automatically authenticate a singular event signal and dynamically generate an event action package as a function of an event notification signal. The operation, for example, may include retrieving a user notification profile (UNP) associated with a user account upon receiving an event notification signal (ENS). For example, the UNP may include relevant entities to be notified in response to the ENS. If the ENS is authorized based on the UNP, for example, the SENS apply an action model to the UNP to generate an event action package to be transmitted to a predetermined destination. For example, the event action package may include customized forms and contact instructions generated based on entities identified based on the UNP. Various embodiments may advantageously generate a timely and secure response to the relevant entities.

Abstract: An online agricultural system manages and optimizes interactions of entities within the system to enable the execution of transaction and the transportation of crop products. The online agricultural system accesses historic and environmental data describing factors that may impact crop product transactions and/or transportation to determine market prices for crop products and crop product transportation. Responsive to receiving a request from an entity, the online agricultural system determines an optimal transaction for the entity, such as a price for selling a crop product, an available crop product for purchase, or a transportation opportunity to transport a crop product.

Abstract: A structure thermodynamic model, which models the physical characteristics of a controlled space, inputs a constraint state curve which gives constraints, such as temperature, that a controlled space is to meet; and outputs a state injection time series which is the amount of state needed for the controlled space to optimize the constraint state curve. The state injection time series curve is then used as input into an equipment model, which models equipment behavior in the controlled space. The equipment model outputs equipment control actions per control time (a control sequence) which can be used to control the equipment in the controlled space. Some embodiments train the models using training data.

Abstract: A method for forming a weapon accessory mounting device to attach to a projectile firing weapon is disclosed. A flexure for receiving a body of the weapon accessory is formed. A pivot portion is formed at a first end of the flexure to attach the flexure to the weapon at a first attachment region. A second attachment portion is formed at a second end of the flexure to attach the flexure to the weapon at a second attachment region. A first aperture is formed in the pivot portion configured to receive a pivot pin. A second aperture in the weapon accessory body receives the pivot pin at a weapon accessory body first end to attach the weapon accessory body first end to the pivot portion. The pivot portion is configured to convert at least a portion of energy of a weapon shock recoil from translational energy to rotational energy.

Abstract: A framework section having a connection region which is formed on the end face of at least one of its two ends. The connection region can be connected to the connection region of a further framework section. The framework section can include two upper chord sections and two lower chord sections, which extend parallel to one another in the longitudinal direction of the framework section and are connected to one another by connecting struts such that they define a cuboid space. The upper chord sections and the lower chord sections can have a tubular cross section, wherein the upper chord sections and the lower chord sections can also be configured to transition from the tubular cross section into an I-shaped cross section in the connection region.

Abstract: Systems and methods for selecting a charging entity based on occupancy status are provided. In one embodiment, a method includes determining a current geo-location and state of charge of a requesting vehicle. A plurality of charging entities that are within a remaining distance of the requesting vehicle are identified. Occupancy statuses for one or more charging entities of the plurality of charging entities are determined. The method also includes estimating charging speeds for the one or more charging entities based on the occupancy statuses. A charging station map user interface that pin points the current geo-location of the requesting vehicle and the one or more charging entities is presented. The one or more charging entities are presented with labels based on the charging speeds. The method further includes reserving a charging station of a selected charging entity of the plurality of charging entities by selecting a label.

Abstract: The present disclosure relates to a solid, enzymatic detergent compositions and methods of making and using the same. In a preferred embodiment, the detergent compositions are particularly useful for cleaning medical and dental instruments. In a preferred embodiment the compositions are particularly use for cleaning ware.

Abstract: Some illustrative embodiments of an instillation assembly for treating a tissue site may include a fluid distribution lumen and a fluid hub that may define a fluid instillation pathway. The fluid distribution lumen may be defined by a first film layer and a second film layer, and the fluid hub may be positioned in fluid communication with the fluid distribution lumen. The instillation assembly may be used in combination with a reduced-pressure assembly that may define a reduced-pressure pathway separate from the fluid instillation pathway.

Abstract: A mobile robot including a vision system, the vision system including a camera and an illumination system; the illumination system including a plurality of light sources arranged to provide a level of illumination to an area surrounding the mobile robot; and a control system for controlling the illumination system. The control system adjusts the level of illumination provided by the plurality of light sources based on an image captured by the camera; an exposure time of the camera at the time the image was captured; and robot rotation information.

Abstract: Provided herein are methods of preparing a poloxamer for use in a cell culture medium. Also provided herein are cell culture media containing the poloxamer prepared by the methods herein, as well as methods of using the media for cell culturing and polypeptide production from cells.

Abstract: A mezuzah having a decorative appearance changeable by a user. The mezuzah comprises a mezuzah casing comprised of an elongated receptacle having at least one opening configured and dimensioned to permit insertion and retention of a parchment klaf therein. At least one decorative cover is configured to close each opening with a secure attachment. The mezuzah casing is configured to be fastened to a door post with at least one fastening element into a position with an opening facing away from the doorpost. The decorative cover is removably securely attached to the mezuzah casing with a structural mechanism to prevent unwanted lateral movement and unwanted removal of the decorative cover relative to the mezuzah casing. As a result, the decorative cover is removable and replaceable, as desired.

Abstract: A finger-mounted device may include finger-mounted units. The finger-mounted units may each have a body that serves as a support structure for components such as force sensors, accelerometers, and other sensors and for haptic output devices. The body may have sidewall portions coupled by a portion that rests adjacent to a user's fingernail. The body may be formed from deformable material such as metal or may be formed from adjustable structures such as sliding body portions that are coupled to each other using magnetic attraction, springs, or other structures. The body of each finger-mounted unit may have a U-shaped cross-sectional profile that leaves the finger pad of each finger exposed when the body is coupled to a fingertip of a user's finger. Control circuitry may gather finger press input, lateral finger movement input, and finger tap input using the sensors and may provide haptic output using the haptic output device.

Abstract: The invention relates to substituted pyrridinobenzodiazepines (PDDs) of formula (XV) and pharmaceutically acceptable salts thereof, which are useful as medicaments, in particular as anti-proliferative agents.

Abstract: A device having a biocompatible polymer as a body and regularly spaced radiation seeds and regularly spaced magnetic materials disposed of within the body of the biocompatible polymer, or uniformly distributed liquid radiation and magnetic fluid materials within a polymer slab, hollow thick wall polymer shell, or thin wall polymer balloon, as suitable for surgical placement within a resection cavity for treatment of at-risk tissue in the tumor margin with local hyperthermia in combination with radiation and potentially also with chemotherapy and/or immunotherapy that is slowly released from the biocompatible polymer.

Abstract: An intervertebral prosthesis for insertion between adjacent vertebrae includes an upper plate, a lower plate and a core. The core is retained between the upper and lower plates by a retention feature in the form of central projections on the plates and a corresponding opening in the core. The retention feature is designed to allow the plates to slide over the upper and lower surfaces of the core in the anterior/posterior direction and in the lateral direction and to allow the plates to rotate with respect to each other and the core. The retention feature is also designed to prevent contact between the first and second plates during sliding movement of the plates over the core. Each central projection has a diameter that is smaller than a smallest diameter of a central opening of the core.

Abstract: Systems and methods for authenticating access to multiple data stores substantially in real-time are disclosed. The system may include a server coupled to a network, a client device in communication with the server via the network and a plurality of data stores. The server may authenticate access to the data stores and forward information from those stores to the client device. An exemplary authentication method may include receipt of a request for access to data. Information concerning access to that data is stored and associated with an identifier assigned to a client device. If the identifier is found to correspond to the stored information during a future request for access to the store, access to that store is granted.

Abstract: In a method for a cooktop, in particular for producing and/or operating the cooktop, which has at least one variable cooking surface, the cooking surface is partitioned in an operating mode along a partitioning direction into a plurality of heating zones to which at least one heating parameter is assigned in each case in a location-dependent manner in order to heat a cooking utensil that is deposited on the heating zone. In order to ensure flexible production and/or flexible operation of the cooktop, during partitioning of the cooking surface into the heating zones in at least one peripheral region of the cooking surface, at least one cooking utensil characteristic is taken into account.