Abstract: An automated weapon system is comprised of a human transported weapon comprising a barrel and munitions; sensing means; targeting means; computational logic for determining where to aim the human transported weapon; aim computational logic; firing activation means; and, firing means, The munitions can be aimed towards a targeting area to be propelled through the barrel. The sensing means senses which of up to a plurality of targets are within firing range of the automated weapon system. The targeting means selects a selected target from the targets in the targeting area that are, within the firing range, responsive to the sensing. The computational logic determines where to aim the human transported weapon so that the munitions will hit the selected target if fired at a firing time. The aim computational logic adjusts the aim of the munitions through the human transported weapon, to compensate as needed for where the selected target is at the firing time, responsive to the determining where to aim.

Abstract: Disclosed are compositions comprising a first liposome, comprising at least one lipid selected from the group consisting of saturated phospholipids, unsaturated phospholipids, mixed phospholipids, and cholesterol, and at least one vasodilator; and a second liposome, comprising at least one lipid selected from the group consisting of saturated phospholipids, unsaturated phospholipids, mixed phospholipids, and cholesterol, at least one thiazolidinedione, and at least one compound having an affinity for at least one component of an atheroma. Also disclosed are methods for forming the compositions and methods of using the compositions to ameliorate atheroma.

Abstract: The present invention relates to a non-human animal model of chronic glaucoma. In addition, the invention refers to a method for the preparation of said animal model, as well as to the use thereof.

Abstract: Apparatuses and methods associated with personal history in a track and trace system are disclosed herein. In embodiments, a method includes acquiring first information corresponding to a physical object; identifying first authentication data based on the first information; storing the first authentication data in a database system; subsequent to storing the first authentication data, acquiring second information corresponding to a target physical object and identifying second authentication data based on the second information; identifying third information corresponding to the target physical object; querying the database system to seek a matching record based on the second authentication data; in the case that a matching record is returned responsive to the querying, updating the matching record with an indication that the second authentication data was matched to it and updating history data of said matching record based on said third information. Other embodiments may be disclosed or claimed.

Abstract: A beverage holder includes a frame, an insert, and a cover. The frame includes a sidewall having an upper end and a lower end, and a bottom wall extending across the lower end. The upper end defines a plurality of protrusions. The sidewall and the bottom wall cooperatively define a chamber. The insert includes a peripheral rim defining a plurality of apertures that receive the plurality of protrusions and a flexible collar extending from the peripheral rim and at least partially into the chamber. The flexible collar defines an opening leading to the chamber. The cover includes a plurality of interfaces that engage with the plurality of protrusions to couple the cover to the upper end of the sidewall and to secure the insert between the frame and the cover. The cover defines an aperture that aligns with the chamber and the opening.

Abstract: Anchors for securing an implant within a body organ and/or reshaping a body organ are provided herein. Anchors are configured for deployment in a body lumen or vasculature of the patient that are curved or conformable to accommodate anatomy of the patient. Such anchors can include deformable or collapsible structures upon tensioning of a bridging element in a lateral direction, or segmented tubes that can be adjusted by tightening of one or more tethers extending therethrough. Such anchors can be used as a posterior anchor in a blood vessel in implant systems having a tensioned bridging element extending between the posterior anchor and an anterior anchor deployed at another location within or along the body organ. Methods of deploying such anchors and use of multiple anchors or multiple bridging elements to a single anchor are also provided.

Abstract: In some embodiments, an integrated virtual button module includes a first transducer, a microcontroller, and a first driver circuit. The first transducer includes a transient strain-sensing element and is configured to generate first signals. The microcontroller is configured to obtain first data from the first signals and determine user inputs in accordance with at least the first data. The first driver circuit is configured to receive user feedback data and to generate a first user feedback signal in accordance with the user feedback data. The first driver circuit is electronically couplable to a first actuator. The user feedback data are determined in accordance with at least the user inputs. The first actuator emits a haptic signal and/or a first audio signal when driven by the first user feedback signal. Embodiments of an integrated virtual button system and a method of determining user input and providing user feedback are also disclosed.

Abstract: Assays (100) may be performed with a luminometer (400) having a chassis (405) that may include a reaction vessel chamber (610). The luminometer (400) may also include a light passage (640) that intersects the reaction vessel chamber (610). The luminometer (400) may also include a cap (415) that, when in a closed configuration, prevents light emitted by external sources from entering the reaction vessel chamber (610) and from entering the light passage (640). The cap (415) may provide access to the reaction vessel chamber (610) when in an open configuration. The luminometer (400) may also include a calibration light source (460) optically coupled to one end of the light passage (640) and a light detector (630) optically coupled to another end of the light passage (640). The light detector (630) may include a sensing element for receiving light from the light passage (640).

Abstract: A delivery apparatus for a medical device implant can include an outer catheter and a flexible delivery catheter. The outer catheter can have an axially extending shaft and a first lumen extending co-axially through the axially extending shaft. The flexible delivery catheter can have an elongate shaft having a flexible section extending along a distal portion of the elongate shaft, and the flexible section of the elongate shaft can be positioned or adjusted between a first, delivery configuration and a second, activated configuration. The delivery catheter can have a pull wire extending co-axially through a second lumen axially extending through the elongate shaft. A distal end of the pull wire can be fixedly secured or attached to the distal end of the elongate shaft.

Abstract: The present disclosure provides methods of modifying a target RNA in a eukaryotic cell. The present disclosure provides methods detecting a target RNA in a eukaryotic cell.

Abstract: Vehicles and methods for augmenting rearview displays for vehicles are provided. An exemplary method is provided for augmenting a rearview display for a vehicle having a gate moveable between a closed configuration and an opened configuration. The method includes collecting dynamic pixel images of an area behind the vehicle using a camera connected to the vehicle. Further, the method includes, in response to a command, displaying graphical overlays to the collected dynamic pixel images on a display screen, via a processor, wherein the graphical overlays depict an outline of the gate and/or projected path of the gate in the opened configuration.

Abstract: A two-part plug assembly is disclosed for a drip-proof spout on an aseptic flexible container for flowable materials. The two-part plug assembly may include a plug and a plug insert, wherein the plug insert may include a flow inhibitor such as a baffle or valve. In a first step, the plug assembly is removably placed in a first position on a spout prior to aseptic filling. During filling, the plug assembly is removed. After filling, the plug insert assembly is replaced in a second position further down the spout wherein the plug insert fixedly engages the spout. When fixedly engaged to the spout, the plug insert remains inside the spout when the plug is removed prior to a user dispensing the flowable material. The flow inhibitor in the plug insert provides protection from leaking when the flexible container is inverted or inadvertently squeezed.

Abstract: Disclosed are methods, and compositions useful for stimulation of immunity towards cancer by utilizing dendritic cells and products therefrom that have been stimulated and/or incorporated mRNA encoding survivin and/or related gene sequences, defined herein as “survivin modified mRNA”. In one embodiment dendritic cells generated from allogeneic “off the shelf” sources are transfected with survivin modified mRNA and the cells are administered in an immunogenic manner. In some embodiments transfected dendritic cells are induced to undergo immunogenic cell death ex vivo subsequently to which they are used as immunogenic stimuli. In other embodiments preparation of the injection site is performed prior to administration of dendritic cells that have been transfected with survivin modified mRNA by pre-administration of agents increasing the number of local dendritic cells in the skin.

Abstract: The invention relates to a binding apparatus (10) for a baling press (1), having a needle rocker (11) having a plurality of binding needles (12) for supplying a binding means to a pressing channel (3), wherein the needle rocker (11) can be driven by means of a motorized drive (40) in such a manner that it moves relative to a frame (2) of the baling press (1) in accordance with a binding cycle, and having a brake apparatus (15) which is configured to apply a braking force (F) which acts at least indirectly on the needle rocker (11). In order to enable an efficient and precise guiding of a needle rocker, there is provision according to the invention for the binding apparatus (10) to be configured in such a manner that the braking force (F) is automatically varied in accordance with at least one parameter relating to the binding apparatus (10).

Abstract: An implant comprises a unitary body including an intramedullary portion connected to an extramedullary portion. The unitary body is configured to attach a first bone section to a second bone section. The intramedullary portion has a first longitudinal axis, and is configured for insertion into the first bone section. The intramedullary portion includes at least one first fastener aperture having an aperture axis oriented obliquely relative to the first longitudinal axis. The extramedullary portion is configured to abut a surface of the second bone section and includes at least one second fastener aperture disposed to transversely receive a bone fastener inserted in the second bone section. The extramedullary portion has a second longitudinal axis offset from, the first longitudinal axis.

Abstract: A method of patterning a substrate includes exposing a photoresist layer on the substrate with a pattern of actinic radiation to form a chemically reactive surface pattern, and coating, at the track system, a spin-on-material to convert the chemically reactive surface pattern to a photoresist surface mask pattern. The method further includes etching the photoresist layer using the photoresist surface mask pattern as a first etch mask to form a photoresist mask pattern, and etching a layer to be etched with the photoresist mask pattern as a second etch mask.

Abstract: The invention described herein relates generally to methods and compositions for administration to modulate the microbiome for the express purpose of increasing host interferon beta (IPN?) in mammals of target populations that are at risk for or are being treated for certain inflammatory conditions including infections, viral infection, autoimmune conditions, and recovery from sequalae associated with acute inflammatory insults. In particular, the invention provides a method of elevating the level of IPN? in the gut of a mammal by providing the mammal with a live bacterium and a prebiotic that the live bacterium is known to consume. Further, the invention described herein may relate to the administration of compositions found to increase the endogenous production of IPN? in the target mammal.

Abstract: A method is provided that is performed by a computer-implemented user support bot. The method includes obtaining from a user a support request related to software and/or hardware used, or to be used, by the user; obtaining user lifecycle journey information that tracks deployment, adoption and/or use by the user of the software and/or hardware; determining a user intent for the support request based on the user lifecycle journey information when there is ambiguity as to the user intent based solely on the support request; and providing a response to the support request based on the user intent.

Abstract: Apparatus and methods for introducing a solid or semi-solid intraocular drug-containing implant into the anterior chamber of an eye are described. The drug-containing implant can be a rod-shaped biodegradable implant that may provide for the extended release of the drug and may be effective for treating a medical condition of the eye. The apparatus is ergonomically designed in the shape or style of a pen with tactile surfaces for easy gripping, a needle-rotation knob to permit orientation of the needle bevel in relation to the eye, and a spring-actuated mechanism for consistent deployment of the implant.

Abstract: A bottle for containing an item, generally a pharmaceutical product, wherein the bottle includes a body having a bottom wall and sidewalls, a neck extending from a top portion of the sidewalls and a thread defined on the neck. The neck defining a mouth of the bottle, an internal surface and an external surface. A neck thickness is defined between the internal surface and the external surface. The thread defines a thread thickness. The thread thickness is substantially the same as the neck thickness.