Abstract: Provided is a process for preparing crystalline imatinib mesylate in substantially pure ?-form, which preferably includes crystallizing imatinib mesylate from an organic solvent containing imatinib and methanesulfonic acid, and seed crystals of imatinib mesylate ?-form, wherein the seed crystals are added before imatinib mesylate begins to precipitate from the mixture. Also provided are stable, free-flowing imatinib mesylate crystals in substantially pure ?-form, and a pharmaceutical composition containing the stable, free-flowing imatinib mesylate crystals.

Abstract: The present invention discloses a novel dental implant anchored to the jawbone by at least two immobilizing means in the jawbone's intrabony portions comprising the proximal crest, medulla and distal crest; suprabony portions or any combination thereof such that the implant is rendered durable to withstand both lateral and perpendicular forces. The present invention also presents kits of multi-anchored dental implants and new methods of implanting the same.

Abstract: The present invention discloses a selective and a non-selective method and means of treating microbial diseases in local infections. The novel method comprising the step of emitting a beam of a blue light towards the tissue to be treated, wherein the beam is having a wavelength from 400 to 550 nanometers and further wherein the temperature of said tissue is not exceeding about 42° C. along the procedure or immediately after it so that a selective phototoxic effect is exerted. A cost effective device for selectively or non-selectively exerting phototoxic effect by emitting a beam of blue light towards a tissue to be treated is also provided useful, especially for dental application.

Abstract: The present invention provides improved processes for preparing the intermediate 7-hydroxy-3,4-dihydro-2(1H)-quinolinone (7-HQ), which may be used in preparing the drug aripiprazole. Among these processes are included three efficient processes for preparing 7-hydroxy-3,4-dihydro-2(1H)-quinolinone comprising reacting N-(3-methoxyphenyl)-3-chloropropionamide with AlCl3 using novel reaction conditions thus obtaining a substantially pure product, which may be used in the subsequent steps for obtaining aripiprazole without further purification.

Abstract: The present invention provides several improved processes for preparing aripiprazole, wherein the first step comprising reacting 7-HQ with a 1,4-disubstituted-butane in biphasic reaction mixture or in a single phase solvent to obtain a 7-(4-halobutoxy)-3,4-dihydro-(1H)-quinolinone (7-HBQ) and the second step comprising reacting the 7-HBQ and 1-(2,3-dichlorophenyl)piperazine or an acid addition salt thereof in a biphasic reaction medium containing water and a water-immiscible solvent to obtain aripiprazole. Also provided are methods of purifying the 7-HBQs and aripiprazole.

Abstract: The present invention provides herein a two-step process for preparing pharmaceutically pure quetiapine and salts thereof by obtaining the starting material 11-chloro-dibenzo-thiazepine followed by reacting the 11-chloro-dibenzo-thiazepine with 1-(2-hydroxyethoxy)ethylpiperazine, or its salt, in the presence of an inorganic or organic base in an organic solvent or in a two-phase solvent system. The present invention provides also a novel, one-pot reaction process for preparing pharmaceutically pure quetiapine and salts thereof. The two processes provided herein can be easily, conveniently and inexpensively scaled-up.

Abstract: A gemstone having a crown, a girdle and a pavilion, wherein the girdle is shaped such that, when viewed in plan view, it is primarily bounded by four pairs of parallel straight edges. Three of the four pairs of edges are spaced by roughly equal spacing D1, while the remaining pair of edges is spaced by a spacing D2, wherein D2 is greater than D1 by between 10% and 40%. Also provided is a method for cutting such a gemstone.

Abstract: The present invention provides novel processes for purifying anastrozole, devoid of using liquid chromatography. The purification processes are via the isolated anastrozole salt forms, either by crystallization or by selective acidic extractions, and optionally in both cases, converting the purified anastrozole salt to anastrozole base. Also provided is an improved process for the synthesis of anastrozole, which is obtained by alkylating the isolated and purified starting material 3,5-bis(2-cyanoprop-2-yl)benzylbromide, the process being devoid of using toxic, hazardous and environmental unfriendly solvents and reagents.

Abstract: A novel process for preparing highly pure cilostazol, effected by reacting 6-hydroxy-3,4-dihydroquinolinone and 5-(4-chlorobutyl)-1-cyclohexyl-1H-tetrazole in the presence of a hydrated inorganic base, is disclosed. Further disclosed is highly pure cilostazol, and particularly highly pure cilostazol that is substantially free of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)-butoxy]-1-[4-(1-cyclohexyl-1H-tetrazol-5-yl)-butyl]-3,4-dihydro-1H-quinolin-2-one.

Abstract: A gemstone having a crown, a girdle and a pavilion, wherein the girdle is shaped such that, when viewed in plan view, it is primarily bounded by four pairs of parallel straight edges. Three of the four pairs of edges are spaced by roughly equal spacing D1, while the remaining pair of edges is spaced by a spacing D2, wherein D2 is greater than D1 by between 10% and 40%. Also provided is a method for cutting such a gemstone.

Abstract: A unified communications protocol for wireless local area networks (WLANs) (400) which provides for the fair co-existence of the IEEE 802.11a (“11a”) and HiPerLAN/2 (“HL2”), broadband communications standards. Wireless network devices (MT's) operating in accordance with 11a and HL2 may co-exist without interference by partitioning a 2 ms periodic lime domain, based on the HL2 standard, into a first slice for use by 11a MT's and a slice for use by HL2 devices. An Arbitrator entity (ARB) broadcasts the time slices periodically at an interval which is greater than or equal to the periodic time domain. A first access Point (E-AP) handles communication with the E-MT's, and a second Access Point (M-AP) handles communications with the e-MTSs and the M-MT's. In this manner, convergence is provided between 11a and HL2, providing users with the best or both worlds, e.g., full interoperability, QoS and co-existence.

Abstract: The invention provides a thiocarboxylic acid organic salt of the formula: 1