Abstract: A method of promoting wound healing, treating fibrosis and/or promoting angiogenesis is provided. The method comprises administering to a subject in need thereof a therapeutically effective amount of a procollagen, thereby promoting wound healing, treating fibrosis and/or promoting angiogenesis in the subject.

Abstract: SP1 and modified SP1 variant polypeptides capable of forming reversible molecular associations with substances, compositions-of-matter comprising same, and uses thereof are provided.

Abstract: A system for assessing a computer device's state may collect state data about the device, then assess the state with respect to the policy for granting one or more claims. Each claim may be defined by a set of requirements that, if fulfilled, may be used to permit or deny access to a resource, such as an application, network, data, or other resource. A collection engine may reside on the device or other location and may collect requested data, and some collection engines may be extensible with a plugin architecture for expansion. A server may receive information from the device to evaluate claims. Depending on the use scenario, the claim results may be incorporated into communications and passed to an evaluator that may produce an access token which is used to permit or deny access based on the claim results.

Abstract: A method of promoting wound healing, treating fibrosis and/or promoting angiogenesis is provided. The method comprises administering to a subject in need thereof a therapeutically effective amount of a procollagen, thereby promoting wound healing, treating fibrosis and/or promoting angiogenesis in the subject.

Abstract: SP1 and modified SP1 variant polypeptides capable of forming reversible molecular associations with substances, compositions-of-matter comprising same, and uses thereof are provided.

Abstract: SP1 and modified SP1 variant polypeptides capable of forming reversible molecular associations with substances, compositions-of-matter comprising same, and uses thereof are provided.

Abstract: A method of generating atelocollagen is disclosed. The method comprises contacting a human telopeptide-comprising collagen with a protease selected from the group consisting of neutrase, subtilisin, ficin recombinant human trypsin and recombinant human pepsin, wherein said human telopeptide-comprising collagen is expressed in a non-animal cell, thereby generating the atelocollagen. Compositions comprising the atelocollagen generated thereby are also disclosed.

Abstract: A system for assessing a computer device's state may collect state data about the device, then assess the state with respect to the policy for granting one or more claims. Each claim may be defined by a set of requirements that, if fulfilled, may be used to permit or deny access to a resource, such as an application, network, data, or other resource. A collection engine may reside on the device or other location and may collect requested data, and some collection engines may be extensible with a plugin architecture for expansion. A server may receive information from the device to evaluate claims. Depending on the use scenario, the claim results may be incorporated into communications and passed to an evaluator that may produce an access token which is used to permit or deny access based on the claim results.

Abstract: A method of generating atelocollagen is disclosed. The method comprises contacting a human telopeptide-comprising collagen with a protease selected from the group consisting of neutrase, subtilisin, ficin recombinant human trypsin and recombinant human pepsin, wherein said human telopeptide-comprising collagen is expressed in a non-animal cell, thereby generating the atelocollagen. Compositions comprising the atelocollagen generated thereby are also disclosed.

Abstract: A method of promoting wound healing, treating fibrosis and/or promoting angiogenesis is provided. The method comprises administering to a subject in need thereof a therapeutically effective amount of a procollagen, thereby promoting wound healing, treating fibrosis and/or promoting angiogenesis in the subject.

Abstract: SP1 and modified SP1 variant polypeptides capable of forming reversible molecular associations with substances, compositions-of-matter comprising same, and uses thereof are provided.

Abstract: The present invention relates to an erythrocyte differentiation factor designed Codanin-1, and to an isolated nucleic acid which encodes for the differentiation factor. Mutations in the differentiation factor are associated with Congenital Dyserythropoietic Anemias (CDA), a group of inherited red blood cell disorders associated with dysplastic changes in late erythroid precursors. The present invention further relates to uses of the differentiation factor to promote the differentiation of hematopoietic stem cells to erythrocytes, as well as for the treatment and diagnosis of anemia.

Abstract: Quantification of the change in shape of the dicrotic notches of so-called distal pressure pulses acquired distal to a lesioned section of a lesioned blood vessel relative to the dicrotic notches of so-called proximal pressure pulses acquired proximal thereto enable determination of values of hemodynamic parameters. The envisaged hemodynamic parameters can include so-called Pulse Transmission Coefficients, non-hyperemic substitutes to the clinically accepted Fractional Flow Reserve and Coronary Flow Reserve indices, and a RC time constant indicative of the health of the vascular bed fed by a lesioned blood vessel.

Abstract: Apparatus for diagnosing lesion severity of a lesion in an arterial lumen supplying blood to a muscle in its non-hyperemic state of a human subject based on processing information relating to the shape of the dicrotic notch of at least one pressure pulse of his proximal non-hyperemic pressure waveform and either the absence of dicrotic notches along his distal non-hyperemic pressure waveform or the shape of the dicrotic notch of at least one pressure pulse of his distal non-hyperemic pressure waveform if present to calculate the value of a PTC parameter indicative of the severity of the lesion.

Abstract: The present invention is directed toward determining a Coronary Flow Reserve (CFR) value for a stenosed blood vessel by way of pressure measurements acquisitioned proximal a stenosis in a stenosed blood vessel and distal thereto both at rest and at hyperemia in accordance with the relationship CFR &agr; (&Dgr;Phyper, &Dgr;Prest) where &Dgr;Phyper and &Dgr;Prest are the pressure gradients across the stenosis at rest and at hyperemia, respectively.

Abstract: The present invention relates to intravascular pressure measurement based devices and methods determining clinical parameters related to stenosis severity for improved clinical diagnosis and treatment of cardiovascular disease in blood vessels or tubular conduits. More specifically, the invention provides methods for the determination of the clinically significant well known Coronary Flow Reserve (CFR) parameter-previously acquired by velocity measurement devices. In addition Coronary Flow Reserve in the same vessel without stenosis may be estimated and uses to select the necessary medical treatment. Additional pressure based clinical parameters, Diastole to Systole Velocity Ratio (DSVR) and Fractional Flow Reserve (FFR) in stenotic blood vessel during intervention (using only pressure measurements across stenosis) may also be calculated simultaneously, with the same set of interventional devices. Correlation of CFR with these parameters (e.g.

Abstract: Apparatus for diagnosing lesion severity of a lesion in an arterial lumen supplying blood to a muscle in its non-hyperemic state of a human subject based on processing information relating to the shape of the dicrotic notch of at least one pressure pulse of his proximal non-hyperemic pressure waveform and either the absence of dicrotic notches along his distal non-hyperemic pressure waveform or the shape of the dicrotic notch of at least one pressure pulse of his distal non-hyperemic pressure waveform if present to calculate the value of a PTC parameter indicative of the severity of the lesion.

Abstract: This invention relates to a method and devices for detection, localization and characterization of occlusions, aneurysms, wall characteristics and vascular bed. The invention is based on introducing an artificial pressure or flow excitation signal (a single signal or more) into the blood vessel (or in other tubular flowing fluid conduits), measurement and analysis of the pressure and or flow. The invention discloses a method and devices for detection and characterization of partial or total occlusion or aneurysm in blood vessels or in other tubular flowing fluid conduits within a body, such as urine flow in the urethra.