Abstract: Disclosed herein are devices and systems that embed a physical layer (e.g., an M-PHY) on a configurable integrated circuit (e.g., an FPGA) and include glue hardware that provides AC coupling between a high-speed serial communication device (e.g., a MIPI device) and the configurable integrated circuit. The glue hardware provides AC coupling using only resistors, capacitors, and inductors. The configurable integrated circuit includes a logic block that manages the operation to provide the desired PHY connectivity. Because the disclosed devices and systems use AC coupling, the signaling drive and receive paths are controlled based on the received signal frequency and not based on the mode (e.g., LS mode or HS mode). Specifically, the line state of the MIPI device is inferred from observation of signal transitions as opposed to direct detection of DC signal levels.

Abstract: Disclosed herein are devices and systems that embed a physical layer (e.g., an M-PHY) on a configurable integrated circuit (e.g., an FPGA) and include glue hardware that provides AC coupling between a high-speed serial communication device (e.g., a MIPI device) and the configurable integrated circuit. The glue hardware provides AC coupling using only resistors, capacitors, and inductors. The configurable integrated circuit includes a logic block that manages the operation to provide the desired PHY connectivity. Because the disclosed devices and systems use AC coupling, the signaling drive and receive paths are controlled based on the received signal frequency and not based on the mode (e.g., LS mode or HS mode). Specifically, the line state of the MIPI device is inferred from observation of signal transitions as opposed to direct detection of DC signal levels.

Abstract: Various apparatuses, systems, methods, and media are disclosed to provide wired communication interface with common mode voltage adjustment for high bit rate communication between devices. In one example, a high speed data communication interface can split the input signal into a high frequency component and a low frequency component. The high speed data communication interface can adjust the common mode voltage using the low frequency component and combine the high frequency component and the low frequency component by superposition after adjusting the common mode voltage.

Abstract: Various apparatuses, systems, methods, and media are disclosed to provide wired communication interface with common mode voltage adjustment for high bit rate communication between devices. In one example, a high speed data communication interface can split the input signal into a high frequency component and a low frequency component. The high speed data communication interface can adjust the common mode voltage using the low frequency component and combine the high frequency component and the low frequency component by superposition after adjusting the common mode voltage.

Abstract: Technologies for control plane separation at a network interface controller (NIC) of a compute device configured to transmit, by a resource of the compute device, commands to a physical function managed by a network interface controller (NIC) of the compute device. The NIC is further to establish a data plane separate from a control plane, wherein the control plane comprises one of the trusted control path and the untrusted control path. Additionally, the resource is configured to transmit the commands via one of the trusted control path or the untrusted control path based on a trust level associated with the physical function. Other embodiments are described herein.

Abstract: Examples described herein relate to software attestation. In some examples, circuitry is to generate measurements for software attestation of a device and wherein the circuitry is a sole generator of the measurements for software attestation for the device. In some examples, the measurements are based on one or more of: firmware image file, software executable binary, device state, and/or fuse measurements. In some examples, generate measurements for software attestation of the device includes performing a cryptographic hash over one or more of: firmware image file, software executable binary, device state, and/or fuse measurements.

Abstract: The disclosure generally relates method, system and apparatus to expedite processing of packet data through a network endpoint. In one embodiment, the disclosure relates to an Inline Security Engine (ISE) which may be deployed at network's edge, for example, at a network interface card or a network adaptor. The exemplary ISE may be configured to receive and analyze packets traversing through the endpoint device for compliance with the encryption protocols and other network requirements. Additionally, the ISE may implement steps to increase security of the data if the analysis suggests that the encryption may be weak or faulty or if certain predefined security rules are violated. All processes are implemented inline and at line speed without diminishing the data rate.

Abstract: Technologies for control plane separation at a network interface controller (NIC) of a compute device configured to transmit, by a resource of the compute device, commands to a physical function managed by a network interface controller (NIC) of the compute device. The NIC is further to establish a data plane separate from a control plane, wherein the control plane comprises one of the trusted control path and the untrusted control path. Additionally, the resource is configured to transmit the commands via one of the trusted control path or the untrusted control path based on a trust level associated with the physical function. Other embodiments are described herein.

Abstract: Method for release of organic materials from shale oil and like solid substances, by treating shale oil powder in a liquid medium, with vortical movements, wave movements, acoustic turbulent streams, or combinations thereof. The treatment causes foaming of the liquid medium followed by separation of the foam from the liquid medium, whereby the foam is enriched with organic materials released from the shale oil powder. The foam can be placed in a liquid organic solvent and treated with vortical movements, wave movements, acoustic turbulent streams, or combinations thereof. The treatment causes the extraction of hydrocarbons into the solvent, and the inorganic shale material to precipitate. The remaining inorganic sold material can be utilized in the manufacture of construction materials. The obtained solution of the extracted hydrocarbons into the solvent represents a synthetic fuel, which could be used after slight reforming as motor fuel, jet fuel, or the like.

Abstract: The disclosure relates to human and mechanical stress induced genes, in particular gene 608, and functional equivalents, probes therefor, tests to identify such genes, polypeptide expression products of such genes, antibodies to the polypeptides, uses for such genes, expression products and antibodies, e.g., in diagnosis (for instance risk determination), treatment, prevention, or control, of osteoporosis or fractures; and to diagnostic, treatment, prevention, or control methods or processes, as well as compositions therefor and methods or processes for making and using such compositions, and receptors therefor and methods or processes for obtaining and using such receptors.

Abstract: This application is directed to a process of identifying a compound capable of modulating activity of a human ENDO180 receptor that comprises the steps of measuring the binding of the ENDO180 receptor to an interactor with which the ENDO180 receptor interacts specifically in vivo, in the absence or presence of a compound, and determining whether the binding of the ENDO180 receptor to the interactor is affected by the compound. This application is also directed to use of a compound identified by that process in the preparation of a medicament for therapy of disease, in particular fibrosis. This application also relates to the use of ENDO180 modulators in treatment of disease.

Abstract: The invention relates to FMS-like tyrosine kinase (FLT3), FLT3 binding pockets or FLT3-like binding pockets. The invention relates to a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. The invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. The invention relates to methods of using the structure coordinates to screen for and design compounds that bind to FMS-like tyrosine kinase protein, complexes of FMS-like tyrosine kinase protein, homologues thereof, or FLT-3-like protein or protein complexes. The invention also relates to crystallizable compositions and crystals comprising an FMS-like tyrosine kinase cytoplasmic domain or homologues thereof. The invention also relates to methods of identifying inhibitors of the cytoplasmic domain of FMS-like tyrosine kinase protein.

Abstract: The present invention relates to use of a novel gene, STR50 and to STR50 modulators in diagnostic, therapeutic and screening aspects related to neurotoxic events. More particularly, the present invention concerns diagnosing and treating neurodegenerative diseases, and screening for species which can be useful in treating the same.

Abstract: This application is directed to a method for the treatment of fibrosis, preferably liver fibrosis, pulmonary fibrosis and cardiac fibrosis, in a subject in need of such treatment comprising administering to said subject an amount of an inhibitor of HNOEL-iso polypeptide sufficient to effect a substantial inhibition of the HNOEL-iso polypeptide so as to thereby treat the subject. This application is also directed to a process of obtaining a compound which inhibits human HNOEL-iso polypeptide. This application is also directed to use of a compound identified by that process in the preparation of a medicament for therapy of disease, in particular fibrosis, and to diagnostic aspects related to HNOEL-iso polypeptide.

Abstract: The invention is based on the discovery of a new class of heterocyclic compounds having, for example, antibacterial properties. The D-Ala-D-Ala ligase enzyme is a critical pathway enzyme in the bacterial cell-wall synthesis. The compounds can bind to and inhibit the enzyme D-Ala-D-Ala ligase. The new compounds' activity combined with their ability to cross bacterial cell membranes makes them suitable for use as antibacterial drugs or other antibacterial applications.

Abstract: The invention relates to D-Ala-D-Ala ligase inhibitors having the formula: wherein R1 is NH2; R2 is NH2; R3 is selected from hydrogen, alkyl, amino, hydroxy, alkoxy, and alkylamino; and R4 and R4? are each independently hydrogen or a substituted or unsubstituted, linear, branched, or cyclic, alkyl, alkenyl, alkynyl, aryl, acyl, aralkyl, or alkaryl group wherein one or more carbon or hydrogen atoms may be substituted by a substituent selected from amino, alkylamino, hydroxyl, alkoxyl, thio, halogen, nitro, and carbonyl; wherein NR4R4? incorporates a substituted or unsubstituted naphthyl group, wherein the substituents are selected from alkoxy, halogen, alkyl, and alkylene, and wherein said naphthyl group in NR4R4? is bonded to N through a substituted or unsubstituted alkylene moiety. These compounds have antibacterial properties based on their ability to bind and inhibit D-Ala-D-Ala ligase, a critical pathway enzyme in bacterial cell-wall synthesis, and are suitable for various antibacterial uses.

Abstract: The invention is based on the discovery that certain small molecules can bind to the ATP binding site of D-Ala-D-Ala ligase, even in the absence of the enzyme's substrate, and can cause a conformational change in the enzyme structure similar to that which occurs upon binding of ATP and substrate to the enzyme. Without wishing to be bound by any theory, it is believed that such a conformational change is required for either activation or inhibition of the enzyme. The information obtained from this discovery has enabled identification of key interactions in the active site of the enzyme, as well as the design and opimization of inhibitors.

Abstract: The disclosure relates to human and mechanical stress induced genes, in particular gene 608, and functional equivalents, probes therefor, tests to identify such genes, polypeptide expression products of such genes, antibodies to the polypeptides, uses for such genes, expression products and antibodies, e.g., in diagnosis (for instance risk determination), treatment, prevention, or control, of osteoporosis or fractures; and to diagnostic, treatment, prevention, or control methods or processes, as well as compositions therefor and methods or processes for making and using such compositions, and receptors therefor and methods or processes for obtaining and using such receptors.

Abstract: The present invention relates to use of Narp inhibitor in order to promote or enhance recovery from ischemic events, particularly focal ischemia of the central nervous system, as well as for preventing or diminishing chronic degenerative changes.

Abstract: The present invention relates to use of Narp inhibitor in order to promote or enhance recovery from ischemic events, particularly focal ischemia of the central nervous system, as well as for preventing or diminishing chronic degenerative changes.