Abstract: The present invention relates to methods for treating medical conditions and/or disorders characterized by uncontrolled or abnormal expression of members of the IL1R3 signaling pathway such as IL-1?, IL-1ß, IL-33, IL-36, IL1RA and/or IL1R3, as well as variants thereof. More specifically, the present invention relates to anti-IL1R3 antibodies for use in the treatment of an IL1R3-mediated inflammatory condition and/or disorder in a subject. Such conditions and disorders include but are not limited to inflammatory diseases, immune disorders, fibrotic disorders, eosinophilic disorders, infection, pain, a central nervous system disorder, an ophthalmologic disorder, Hereditary Systemic Inflammatory Diseases, and Systemic and Local Inflammatory Diseases and cancer associated chronic inflammation.

Abstract: An apparatus comprising a transmission unit comprising a light element that is configured to emit light in a predefined wavelength range; and a transmission optics that is configured to direct the emitted light to an object; a reception unit comprising a first reception element; a second reception element that is arranged spaced apart from the first reception element; and a reception optics that is configured to receive light remitted by the object and to direct it to the first reception element and the second reception element; and an evaluation unit that is configured to evaluate light received by the first reception element and to determine a distance of the object and to evaluate light received by the second reception element and to determine a color of the object.

Abstract: The present disclosure identifies pathways, mechanisms, systems and methods to confer chemoautotrophic production of carbon-based products of interest, such as sugars, alcohols, chemicals, amino acids, polymers, fatty acids and their derivatives, hydrocarbons, isoprenoids, and intermediates thereof, in organisms such that these organisms efficiently convert inorganic carbon to organic carbon-based products of interest using inorganic energy, such as formate, and in particular the use of organisms for the commercial production of various carbon-based products of interest.

Abstract: A cleaning section for an electric oral hygiene device includes a carrier mounted for driven rotation and/or oscillating rotation around a rotation axis, at least a plurality of first cleaning elements and a plurality of second cleaning elements, the cleaning elements being mounted on a mounting surface of the carrier. The carrier has an outer rim and an inner portion. The plurality of first cleaning elements are arranged at the inner portion of the carrier, and the plurality of second cleaning elements are arranged at the outer rim of the carrier. The plurality of first cleaning elements have a longitudinal axis and a substantially cross-shaped cross-sectional area extending in a plane substantially perpendicular to the longitudinal axis, the cross-shaped cross-sectional area having four projections and four channels, the projections and channels being arranged in an alternating manner.

Abstract: A method for checking the integrity of functional units that are reloadable during runtime of an electronic component in a dynamically reconfigurable region of the electronic component, wherein the electronic component, which is formed as a programmable logic circuit, has, in addition to a static region, a dynamically reconfigurable region and the reloadable functional units have predefined interfaces, where an associated twin functional unit is configured in a specified subregion of the dynamically reconfigurable region for each reloadable functional unit, a reloadable functional unit is loaded into a specified subregion of the dynamically reconfigurable region, supplied with identical input data to the associated twin functional unit, and executed in parallel with the twin functional unit, and where output data of the reloaded functional unit and associated twin functional unit are compared and the reloaded functional unit is enabled if a match between the two output data is found.

Abstract: A valve has a valve housing with a valve seat and a valve body holder with a fluid-permeable flow opening. A valve body is arranged in the valve body holder and axially displaceable between an open state and a closed state of the valve. The valve body has an envelope surface with a sealing region for fluid-tightly contacting the valve seat in the closed state. It has a base region adjoining the sealing region in longitudinal direction. A cross section contour of the envelope surface increases monotonously from the sealing region to the base region. In the open state, an axial end of the base region contacts the valve body holder. The envelope surface has a weakened region connecting sealing region and base region to each other. The weakened region has a reduced stiffness along the longitudinal direction. The valve body is formed of a thermoplastic polyhalogen olefin.

Abstract: The present disclosure relates to antibody-drug conjugates (ADCs) wherein one or more active agents are conjugated to an anti-CD19 antibody through a linker. The linker may comprise a unit that covalently links active agents to the antibody. The disclosure further relates to monoclonal antibodies and antigen binding fragments, variants, multimeric versions, or bispecifics thereof that specifically bind CD19, as well as methods of making and using these anti-CD19 antibodies and antigen-binding fragments thereof in a variety of therapeutic, diagnostic and prophylactic indications.

Abstract: The invention relates to a method for determining the mass and the center of gravity location of a load (10) of a moving system (12), particularly of a machine tool (14), which comprises a support (20) that is for accommodating the load (10) and is able to rotate around a first axis (16) and a second axis (18) as well as electronically controlled drive units (22, 24) for rotating the support (20) around the first axis (16) and around the second axis (18), wherein a total moment of inertia and a holding torque with regard to the first axis (16) are determined in a loaded state; a total moment of inertia and a holding torque with regard to the second axis (18) are determined in the loaded state; and the mass and the center of gravity location of the load (10) relative to the support (20) are determined based on the total moments of inertia and the holding torques with regard to the first axis (16) and second axis (18).

Abstract: Leaderboard with irregularity flags in an exercise machine system. In one aspect of the disclosure, a method may include executing a video workout program on first and second exercise machines, monitoring first and second performance parameters of first and second users during the execution of the video workout program, displaying a leaderboard which displays and ranks first and second performance indicators of the first and second users based on the first and second performance parameters, detecting an irregularity in the first performance parameters of the first user, and updating the leaderboard to display an irregularity flag associated with the first performance indicator of the first user to indicate the irregularity in the performance of the first user during the workout.

Abstract: The invention relates to a method for allowing users to categorize transactions at moment-of-sale using mobile payments. The method includes detecting a transaction performed on a mobile device. The method further includes prompting, a user of the mobile device to provide a categorization of the transaction as a business transaction or a personal transaction, where the transaction is categorized by the user contemporaneously with the transaction being detected by the FMA interface. The method further includes receiving the transaction and the categorization of the transaction from the user. The method further includes sending the FMA time stamp of the transaction with the categorization as the business transaction, Finally, the method includes matching the FMA time stamp of the business transaction to a financial institution time stamp of a pending transaction.

Abstract: A fastening member for joining together adjacent duct sections includes a head and a shank extending from the head, the shank having an unthreaded space adjacent to the head and a threaded portion extending from the unthreaded space, the threaded portion threadedly engaging a hole of an inserted corner plate positioned in flange of a first duct section. When the fastening member is fully inserted, the inserted corner plate positioned in the flange of the first duct section is retained within the unthreaded space.

Abstract: The invention relates to a method for operating a piston compressor (100) having a reciprocating piston (111) in a cylinder (110), wherein an inlet valve (112) and an outlet valve (113) are provided in the cylinder (110) on the side of a medium (b) which is to be compressed and conveyed, wherein the reciprocating piston (111) is moved to and fro by way of a hydraulic drive (120, 121) with a hydraulic piston (120) with the use of a hydraulic medium (a) in a first volume (141), with which the reciprocating piston (111) is loaded on the side of the hydraulic drive (120, 121), wherein, if required, hydraulic medium (a) is fed into the first volume (141) and/or is discharged from the first volume (141) in a manner which is dependent on a position of the hydraulic piston (120) and/or a rotational angle ((p) of a shaft (121) which is provided for moving the hydraulic piston (120) in relation to a position (x) of the reciprocating piston (120) and/or a pressure (p) in the first volume (141), and to a piston compresso

Abstract: A transducer array (802) includes at least one 1D array of transducing elements (804). The at least one 1D array of transducing elements includes a plurality of transducing elements (904). A first of the plurality of transducing elements has a first apodization and a second of the plurality of transducing elements has a second apodization. The first apodization and the second apodization are different. The transducer array further includes at least one electrically conductive element (910) in electrical communication with each of the plurality of transducing elements. The transducer array further includes at least one electrical contact (906) in electrical communication with the at least one electrically conductive element. The at least one electrical contact concurrently addresses the plurality of transducing elements through the at least one electrically conductive element.

Abstract: A device that prints with ink includes an ink reservoir for ink and an arrangement of multiple printing elements, for instance printing heads. The printing elements are identical with one another, they generate ink drops, and they are supplied in parallel with ink from a joint supply line. A further element, which is different from the printing element and which is controllable in terms of its ink flow, for instance a pump, is supplied with ink in parallel with the printing elements by the same supply line. Undesirable hydrostatic pressure changes in the ink are reduced as much as possible, or even eliminated.

Abstract: The present invention is directed to a method for identifying neural invasion in a pancreatic cancer patient, the method comprising the steps of: determining in a sample of a pancreatic cancer patient the expression level of PlGF and sFlt1; and calculating a ratio of the expression levels of PlGF and sFlt1, wherein the expression level of PlGF forms part either of the numerator or of the denominator of the ratio; characterized in that, a deviation of the ratio of the patient sample from a reference sample or a predetermined threshold value is indicative for presence of neural invasion of the pancreatic cancer in said patient.

Abstract: Provided are methods for treating or preventing Parkinson's disease or dementia with Lewy Bodies in a human subject. The methods target lipid dysregulation in brain tissue of the subject and can, in particular, reduce the concentration of glycosphingolipids in brain tissue. The methods use quinuclidine compounds of formula (I), or pharmaceutically acceptable prodrugs or salts thereof. In particular, the human subject may be a carrier of one or more glucocerebrosidase 1 gene (GBA1) mutations, e.g. a heterozygous carrier of GBA1 mutations. Also provided are methods for assessing the effectiveness of treatments as described herein.

Abstract: The invention relates to a process for the recovery of aliphatic hydrocarbons from a liquid stream comprising aliphatic hydrocarbons, heteroatom containing organic compounds and optionally aromatic hydrocarbons, involving (i) contacting said liquid stream with a washing solvent thereby removing heteroatom containing organic compounds; a) liquid-liquid extraction of the washed stream with an extraction solvent thereby recovering part of the aliphatic hydrocarbons; b1) mixing the extract stream, comprising extraction solvent, aliphatic hydrocarbons, heteroatom containing organic compounds and optionally aromatic hydrocarbons, with a demixing solvent to recover additional aliphatic hydrocarbons; b2) mixing the remaining stream with additional demixing solvent to remove heteroatom containing organic compounds and optional aromatic hydrocarbons; and c) separation of the remaining stream into a demixing solvent stream and an extraction solvent stream.

Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: A modular, radio frequency (“RF”) system includes one or more directional antennas and is configured with both hardware and software components to enable the RF system to monitor (e.g., detect or track signals or objects) and/or interact with (e.g., track signals or objects, or transmit signals) objects in particular directions. The RF system includes one or more machine learning models to determine, based on received signals, one or more signals to transmit.

Abstract: A positron emission tomography (PET)-scanning device is provided, having a detector ring for detecting emitted PET-radiation and a main supporting structure which has or to which is attached a U-shaped portion with two arms for holding the detector ring between the arms. The detector ring is held by the two arms in such a way that the detector ring can be rotated about an axis of rotation that extends through the U-shaped portion, in particular through the two arms of the U-shaped portion.