Patents by Inventor Or Gadish

Or Gadish has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF ASSAYING MICRO-OBJECTS IN A MICROFLUIDIC DEVICE
    Publication number: 20250027941
    Abstract: This application describes systems and methods for assaying micro-objects in a microfluidic device. These methods include contacting a reagent with a micro-object by introducing a reagent in a first fluidic medium to a flow region of a microfluidic device, wherein the microfluidic device comprises the flow region and a chamber comprising a proximal opening fluidically connecting the chamber to the flow region, diffusing the reagent from the flow region into the chamber; introducing a micro-object into the flow region of the microfluidic device, and diffusing the reagent from the chamber to the flow region to contact the reagent with the micro-object within the flow region. Other embodiments are described.
    Type: Application
    Filed: July 25, 2024
    Publication date: January 23, 2025
    Applicant: BRUKER CELLULAR ANALYSIS, INC.
    Inventors: Ke-Chih LIN, Long Van LE, Jason M. MCEWEN, J. Tanner NEVILL, Volker L.S. KURZ, Peyton SHIEH, Alexander J. MASTROIANNI, Or GADISH, Ethan Jun Wei GOH
  • APPARATUSES, METHODS, AND KITS FOR MICROFLUIDIC ASSAYS
    Publication number: 20240318120
    Abstract: Methods, systems, and kits for determining a level of dissolved oxygen within a microfluidic device are provided. The microfluidic device can be suitable for cell culture. The methods, systems, and kits can further be used to determine a level of oxygen consumption in a population of biological micro-objects. In particular, the methods, systems, and kits of the present disclosure rely on flowing a fluidic medium containing a dye and a supplied partial pressure of oxygen into the microfluidic device for a period of time, wherein fluorescence emitted by the dye changes based on availability of oxygen proximate to the dye; taking a fluorescence image of an area of interest within the chamber; and correlating fluorescence of the fluorescence image of the area of interest to a reference to determine an observed partial pressure of the oxygen in the area of interest.
    Type: Application
    Filed: August 30, 2021
    Publication date: September 26, 2024
    Applicant: BRUKER CELLULAR ANALYSIS, INC.
    Inventors: Patrick N. INGRAM, Alexander CHIEN, Ke-Chih LIN, Or GADISH, Troy A. LIONBERGER, Eric K. SACKMANN, Volker L.S. KURZ, Alexander J. MASTROIANNI, Randall D. LOWE, JR., Jonathan Cloud Dragon HUBBARD
  • Methods of Microfluidic Assay and Bioproduction from Non-Mammalian Cells and Kits Therefor
    Publication number: 20240302378
    Abstract: Metabolic engineering has developed microbial cell factories as sustainable alternatives to chemical synthesis from petroleum feedstocks or harvesting of animals and plants, but current methods can be a costly and labor-intensive commitment. Methods are described herein for microfluidic methods of screening thousands of variant cells in order to reduce time and uncertainty to provide improved strains.
    Type: Application
    Filed: October 5, 2023
    Publication date: September 12, 2024
    Applicant: Bruker Cellular Analysis, Inc.
    Inventors: Or Gadish, Kellen C. Mobilia, Sara Tafoya, Eric K. Sackmann, Alexander J. Mastroianni, Peyton Shieh, Smriti Sridhar, Pierre Sphabmixay, Eva Y. Cheung, Grayson T. Wawrzyn, Long V. Le, Nathan J. Ver Heul, Bo Hu, Lily Chao, Ke-Chih Lin, Volker L.S. Kurz, Robert M. Onorato
  • METHOD FOR ASSAYING A MICRO-OBJECT WITHIN A MICROFLUIDIC DEVICE
    Publication number: 20230375447
    Abstract: The present disclosure relates to methods for assaying and controlling micro-objects in a microfluidic device. In situ-generated hydrogel barriers are provided for dividing a microfluidic chamber into areas where assaying a cell may be performed without interference from the presence of the cell itself.
    Type: Application
    Filed: March 27, 2023
    Publication date: November 23, 2023
    Inventors: Alexander J. MASTROIANNI, Peyton SHIEH, Kellen C. MOBILIA, Eric K. SACKMANN, Ke-Chih LIN, Or GADISH, Patrick N. INGRAM, Eric Chun-Jen SHIUE, Grayson Thomas WAWRZYN, Volker L.S. KURZ, Nathan J. VER HEUL, Randall D. LOWE, JR., Sara TAFOYA
  • In situ antigen-generating cancer vaccine
    Patent number: 10406216
    Abstract: The invention provides compositions and methods for utilizing scaffolds in cancer vaccines.
    Type: Grant
    Filed: November 7, 2016
    Date of Patent: September 10, 2019
    Assignee: President and Fellows of Harvard College
    Inventors: Jaeyun Kim, David J. Mooney, Weiwei Aileen Li, Praveen Arany, Or Gadish
  • IN SITU ANTIGEN-GENERATING CANCER VACCINE
    Publication number: 20170182138
    Abstract: The invention provides compositions and methods for utilizing scaffolds in cancer vaccines.
    Type: Application
    Filed: November 7, 2016
    Publication date: June 29, 2017
    Inventors: Jaeyun Kim, David J. Mooney, Weiwei Aileen Li, Praveen Arany, Or Gadish
  • In situ antigen-generating cancer vaccine
    Patent number: 9486512
    Abstract: The invention provides compositions and methods for utilizing scaffolds in cancer vaccines.
    Type: Grant
    Filed: June 4, 2012
    Date of Patent: November 8, 2016
    Assignee: President and Fellows of Harvard College
    Inventors: Jaeyun Kim, David J. Mooney, Weiwei Aileen Li, Praveen Arany, Or Gadish
  • In Situ Antigen-Generating Cancer Vaccine
    Publication number: 20140193488
    Abstract: The invention provides compositions and methods for utilizing scaffolds in cancer vaccines.
    Type: Application
    Filed: June 4, 2012
    Publication date: July 10, 2014
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Jaeyun Kim, David J. Mooney, Weiwei Aileen Li, Praveen Arany, Or Gadish