Abstract: Provided are the crystalline solid meglumine salts of (R)-5-(4-chlorophenyl)-1-isopropyl-2-methyl-4-(3-(4-(4-((4-((1-(phenylthio)-4-(4-((phosphonooxy)methyl)piperidin-1-yl)butan-2-yl)amino)-3- ((trifluoromethyl)sulfonyl)phenyl)sulfonamido)phenyl) piperazin-1-yl)phenyl)-1H-pyrrole-3-carboxylic acid. Pharmaceutical compositions having one or more of the crystalline solid meglumine salt compounds and methods for administering the crystalline solid meglumine salt compounds to a subject are also described. Methods for preparing the crystalline solid meglumine salt compounds are also provided.

Abstract: A system includes a plurality of storage processing accelerators (SPAs), at least one SPA of the plurality of SPAs including a plurality of programmable processors or storage processing engines (SPEs), the plurality of SPEs including n SPEs (n is a natural number greater than zero), where 1st to (n?1) SPEs of the n SPEs are configured to provide an output of the SPE to a next SPE of the n SPEs in a pipeline to be used as an input of the next SPE; and an acceleration platform manager (APM) connected to the plurality of the SPAs and the plurality of SPEs, and configured to control data processing in the plurality of SPAs and the plurality of SPEs.

Abstract: Implementations are directed to causing a voice bot to utilize a plurality of ML layers in resolving unique personal identifier(s) for a human while the voice bot is engaged in a corresponding conversation with the human. The unique personal identifier(s) can include a unique sequence of alphanumeric characters that is personal to the human. In some implementations, ASR speech hypothes(es) corresponding to spoken utterance(s) that include the unique personal identifier(s) can be processed to generate candidate unique personal identifier(s), given alphanumeric character(s) of the candidate unique personal identifier(s) can be selected, and the voice bot can prompt the human with clarification request(s) to clarify the given alphanumeric character(s) until it is predicted to correspond to the an actual unique personal identifier(s) for the human(s). The unique personal identifier(s) can then be utilized in performance of further action(s) by the voice bot and/or other systems.

Abstract: According to one general aspect, a device may include a host interface circuit configured to communicate with a host device via a data protocol that employs data messages. The device may include a storage element configured to store data in response to a data message. The host interface circuit may be configured to detect when a tunneling command is embedded within the data message; extract a tunneled message address information from the data message; retrieve, via the tunneled message address information, a tunneled message stored in a memory of the host device; and route the tunneled message to an on-board processor and/or data processing logic. The on-board processor and/or data processing logic may be configured to execute one or more instructions in response to the tunneled message.

Abstract: The invention relates to novel crystalline solid forms of the chemical compound N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N?-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (Compound 1), and solvates thereof, including hydrates, that are useful for the treatment of cancer. Also disclosed are pharmaceutical compositions comprising the crystalline solid forms and processes for making the crystalline solid forms, as well as methods of using them for the treatment of cancer, particularly thyroid cancer, prostate cancer, hepatocellular cancer, renal cancer, and non-small cell lung carcinoma. The crystalline solid forms can be used to make the L-malate salt of cabozantinib.

Abstract: Implementations are directed to causing a voice bot to utilize a plurality of ML layers in resolving unique personal identifier(s) for a human while the voice bot is engaged in a corresponding conversation with the human. The unique personal identifier(s) can include a unique sequence of alphanumeric characters that is personal to the human. In some implementations, ASR speech hypothes(es) corresponding to spoken utterance(s) that include the unique personal identifier(s) can be processed to generate candidate unique personal identifier(s), given alphanumeric character(s) of the candidate unique personal identifier(s) can be selected, and the voice bot can prompt the human with clarification request(s) to clarify the given alphanumeric character(s) until it is predicted to correspond to the an actual unique personal identifier(s) for the human(s). The unique personal identifier(s) can then be utilized in performance of further action(s) by the voice bot and/or other systems.

Abstract: A system includes a plurality of storage processing accelerators (SPAs), at least one SPA of the plurality of SPAs including a plurality of programmable processors or storage processing engines (SPEs), the plurality of SPEs including n SPEs (n is a natural number greater than zero), where 1st to (n?1) SPEs of the n SPEs are configured to provide an output of the SPE to a next SPE of the n SPEs in a pipeline to be used as an input of the next SPE; and an acceleration platform manager (APM) connected to the plurality of the SPAs and the plurality of SPEs, and configured to control data processing in the plurality of SPAs and the plurality of SPEs.

Abstract: The invention relates to novel crystalline solid forms of the chemical compound N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N?-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide (Compound 1), and solvates thereof, including hydrates, that are useful for the treatment of cancer. Also disclosed are pharmaceutical compositions comprising the crystalline solid forms and processes for making the crystalline solid forms, as well as methods of using them for the treatment of cancer, particularly thyroid cancer, prostate cancer, hepatocellular cancer, renal cancer, and non-small cell lung carcinoma. The crystalline solid forms can be used to make the L-malate salt of cabozantinib.

Abstract: The invention relates to novel crystalline solid forms of the chemical compound N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N?-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide (Compound 1), and solvates thereof, including hydrates, that are useful for the treatment of cancer. Also disclosed are pharmaceutical compositions comprising the crystalline solid forms and processes for making the crystalline solid forms, as well as methods of using them for the treatment of cancer, particularly thyroid cancer, prostate cancer, hepatocellular cancer, renal cancer, and non-small cell lung carcinoma. The crystalline solid forms can be used to make the L-malate salt of cabozantinib.

Abstract: According to one general aspect, a device may include a host interface circuit configured to communicate with a host device via a data protocol that employs data messages. The device may include a storage element configured to store data in response to a data message. The host interface circuit may be configured to detect when a tunneling command is embedded within the data message; extract a tunneled message address information from the data message; retrieve, via the tunneled message address information, a tunneled message stored in a memory of the host device; and route the tunneled message to an on-board processor and/or data processing logic. The on-board processor and/or data processing logic may be configured to execute one or more instructions in response to the tunneled message.

Abstract: Disclosed herein are processes for synthesizing 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)-pyridin-3-yl)methoxy)benzaldehyde (also referred to herein as Compound (I)) and intermediates used in such processes. Compound (I) binds to hemoglobin and increases its oxygen affinity and hence can be useful for the treatment of diseases such as sickle cell disease.

Abstract: A system and method for leveraging a native operating system page cache when using non-block system storage devices is disclosed. A computer may include a processor, memory, and a non-block system storage device. A file system may be stored in memory and running on the processor, which may include a page cache. A key-value file system (KVFS) may reside between the file system and the storage device and may map received file system commands to key-value system commands that may be executed by the storage device. Results of the key-value system commands may be returned to the file system, permitting the operating system to cache data in the page cache.

Abstract: Disclosed herein is a process of making a compound of formula I The compound of formula I is an inhibitor of MEK and thus can be used to treat cancer.

Abstract: Implementations are directed to causing a voice bot to utilize a plurality of ML layers in resolving unique personal identifier(s) for a human while the voice bot is engaged in a corresponding conversation with the human. The unique personal identifier(s) can include a unique sequence of alphanumeric characters that is personal to the human. In some implementations, ASR speech hypothes(es) corresponding to spoken utterance(s) that include the unique personal identifier(s) can be processed to generate candidate unique personal identifier(s), given alphanumeric character(s) of the candidate unique personal identifier(s) can be selected, and the voice bot can prompt the human with clarification request(s) to clarify the given alphanumeric character(s) until it is predicted to correspond to the an actual unique personal identifier(s) for the human(s). The unique personal identifier(s) can then be utilized in performance of further action(s) by the voice bot and/or other systems.

Abstract: The invention provides a system and method for customizing one or more Uniform Resource Locator (URLs), including defining configuration rules which governs customization of one or more URLs; reading and loading the configuration rules to a computing device using a software means; activating an event listener means for identifying an event of a content copied to a temporary or other storage location of the computing device; extracting content for customization from the copied content; requesting a customization server to customize the extracted content based on the configuration rules; returning one or more customized URLs to the software means; and replacing the extracted content with one or more returned customized URLs. The invention enables users to obtain customized or branded URLs without interrupting the natural work process of copying and pasting and without any additional steps involved. The invention allows customization of URLs when a content is updated.

Abstract: Disclosed herein are processes for synthesizing 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)-pyridin-3-yl)methoxy)benzaldehyde (also referred to herein as Compound (I)) and intermediates used in such processes. Compound (I) binds to hemoglobin and increases its oxygen affinity and hence can be useful for the treatment of diseases such as sickle cell disease.

Abstract: A system and method for leveraging a native operating system (130) page cache (315) when using non-block system storage devices (120) is disclosed. A computer (105) may include a processor (110), memory (115), and a non-block system storage device (120). A file system (135) may be stored in memory (115) and running on the processor (110), which may include a page cache (315). A key-value file system (KVFS) (145) may reside between the file system (135) and the storage device (120) and may map received file system commands (310) to key-value system commands (330) that may be executed by the storage device (120). Results of the key-value system commands (330) may be returned to the file system (135), permitting the operating system (130) to cache data in the page cache (315).

Abstract: The invention provides a system and method for customizing one or more Uniform Resource Locator (URLs), including defining configuration rules which governs customization of one or more URLs; reading and loading the configuration rules to a computing device using a software means; activating an event listener means for identifying an event of a content copied to a temporary or other storage location of the computing device; extracting content for customization from the copied content; requesting a customization server to customize the extracted content based on the configuration rules; returning one or more customized URLs to the software means; and replacing the extracted content with one or more returned customized URLs. The invention enables users to obtain customized or branded URLs without interrupting the natural work process of copying and pasting and without any additional steps involved. The invention allows customization of URLs when a content is updated.

Abstract: The invention relates to a method and system for delivering content over a network, and for delivering content from servers such as a main domain web server and a redirection server, using the same domain name. The invention includes delivering content over a network from the servers. The invention includes delivering content from a web server and a redirection server over the same domain name. This enables safe and efficient creation of branded links using the branded domain name of an organization. Branded links using the same branded domain name of an organization enhances brand awareness and brand recognition. Such links are more trusted by readers since the link is branded to give the reader an understanding of where the link will lead them, therefore, increasing the trust attributed to a link.

Abstract: Disclosed are systems and methods for ambient sound enhancement on a mobile device. A user hearing profile is generated and a set of ambient sound enhancement digital signal processing (DSP) parameters is calculated for a sound enhancement algorithm, based at least in part on the user hearing profile. In response to a user initiating an ambient sound enhancement function on a mobile computing device, at least one set of calculated ambient sound enhancement DSP parameters is retrieved. Ambient sound is captured with a microphone of the mobile computing device and processed with an ambient sound enhancement DSP. The ambient sound enhancement DSP is parameterized with the retrieved set of calculated ambient sound enhancement DSP parameters and the DSP enhanced processed audio signal is outputted to a transducer of the mobile device.