Abstract: A series of pharmaceutical metal complexes (pMCs) were produced and characterized using the mast cell stabilizer, cromolyn, and bioactive metal ions (Zn+2, Mg+2, and Ca+2). Three novel pMCs, Cromolyn-Zn, Cromolyn-Mg, and Cromolyn-Ca were formed through reactions under controlled temperature and pH conditions. TGA demonstrated that these metal complexes showed an enhanced thermal stability due to the strong coordination with the ligand, cromolyn. PXRD data indicates a high degree of crystallinity as well as a unique packing arrangement for each pMCs. SEM analysis showed materials with well-defined morphologies while EDS presented elemental evidence for the unique composition of each pMCs. The crystal structure for these materials was elucidated through SCXRD, and a variety of binding modes and packing motifs were found within each respective metal complex. Only 2D structures were achieved under the conditions studied.

Abstract: The present invention provides methods for treating, reducing the severity, or inhibiting the growth of cancer (e.g., lung cancer). The methods of the present invention comprise administering a therapeutically effective amount of a programmed death 1 (PD-1) antagonist (e.g., an anti-PD-1 antibody), to a subject with lung cancer wherein the cancer tissue expresses PD-L1.

Abstract: Methods and systems are provided for facilitating shopping for products that have been liked to a social media network. A product can be seen on a merchant's website, for example. The product can be liked by user to the social media website. When the same or a different user subsequently sees the liked product on the social media website, the same or different user can purchase the product from the social media website. Thus, the user is not required to visit the merchant's website to perform the purchase transaction. Upon completion of the purchase, the user can be allowed to leave feedback to rate the item according to a predefined scale, which can be visible to all those who view the item, as exhibited by a vendor on the social media platform.

Abstract: Systems for positioning a patient are provided. A patient positioning system comprising: an upper support comprising: a mounting plate for a pad; a hinge comprising a curved surface including teeth, the curved surface operable to rotate; a pawl that is in contact with the teeth of the hinge, wherein the pawl is operable to allow rotation of the pad in a first direction due to angles of the teeth; a moveable member extending from the hinge, the moveable member including teeth; and a second pawl that is in contact with the teeth of the moveable member, the second pawl operable to allow movement of the moveable member due to angles of the teeth of the moveable member; and a lower support connected to the upper support via the moveable member.

Abstract: A system for electrophysiological measurement includes a probe having a distal end configured for insertion into a body cavity of a living subject and including an array of electrodes that are disposed along the distal end and are configured to contact tissue at multiple locations within the body cavity. A processor is configured to acquire signals from the electrodes over a period of time during which the probe moves within the body cavity, to compute, in response the signals, metrics that are indicative of a respective quality of contact between each of the electrodes and the tissue over the period of time, and to output an indication of the metrics to a user of the system.

Abstract: A system for controlling and monitoring flow in a cuffed endotracheal tube device is disclosed. The system comprises: a connector panel having at least three connectors adapted for establishing fluid communication with proximal ends of at least a first fluid line, a second fluid line and a cuff inflation line of the endotracheal tube device. The system can further comprise a processing unit and a control unit, wherein the processing unit is configured to instruct the control unit to execute various operations, including at least a rinsing procedure, a suctioning procedure, a cuff inflation procedure, a leak detection procedure and a venting procedure, and to select any of the first and the second fluid lines for any of the rinsing, suctioning, leak detection and venting procedures. In some embodiments, the system exploits the cuff as sensor to sense pulmonary data.

Abstract: B-cell maturation antigen (BCMA) is expressed on malignant plasma cells. The present invention provides methods for treating multiple myeloma using bispecific antibodies (bsAbs) that bind to both BCMA and CD3 and activate T cells via the CD3 complex in the presence of BCMA-expressing tumor cells. In certain embodiments, the bispecific antigen-binding molecules of the present invention are capable of inhibiting the growth of tumors expressing BCMA.

Abstract: An energy-moving device (EMD) transfers heat between a low-temperature-rated device (LTRD) and a high-temperature-rated device (HTRD), wherein the LTRD is thermally separated from the HTRD such that the LTRD is not stacked above the HTRD. A temperature-controlling device (TCD) actively transfers heat between the LTRD and the EMD. An air-moving device (AMD) generates an air stream for transferring heat from the EMD to ambient air. A controller receives temperature information about the ambient air, the LTRD, and the HTRD; determines when heat should be removed from the LTRD, when heat should be added to the LTRD, and when no heat needs to be transferred to or from the LTRD; and determines a first voltage for the TCD and a second voltage for the AMD based on the received temperature information. And a neural network updates the voltage values based on how effectively the voltage values have performed.

Abstract: Systems, apparatuses and methods may provide for technology to improve a workout experience of a user by determining an emotional state of the user, identifying a workout route based on the emotional state of the user, and outputting the workout route via a user interface device. Additionally, determining the emotional state of the user may include inferring emotions from one or more sensor information or user speech information. In one example, the sensor information includes one or more of blood pressure signals, heart rate signals or sweat measurement signals and the user speech information includes one or more of words used in an input utterance or a prosody of the input utterance.

Abstract: Provided herein are kits comprised of a first container including a solution of fibrinogen-containing component that includes fibrinogen at a concentration range of about 5 mg/ml to about 30 mg/ml, and having a total protein concentration range of about 15 mg/ml to about 40 mg/ml; and a second container that includes a solution of thrombin-containing component. Further provided are mixtures comprised of fibrinogen and thrombin, calcium ions, and albumin, the mixture being comprised of total protein in a range of about 2.5 mg/ml to about 30 mg/ml, fibrinogen in a range of about 50% to about 80% of total protein, and albumin in a range of more than 0.65 mg/ml to about 3 mg/ml. Further provided herein are methods for preventing or reducing tissue adhesion, and hydrogel materials made of fibrin.

Abstract: An apparatus for optimizing a patient's insulin dosage regimen over time, comprising: at least a first computer-readable memory for storing data inputs corresponding at least to one or more components in a patient's present insulin dosage regimen and the patient's blood-glucose-level measurements determined at a plurality of times; a processor operatively connected to the at least first computer-readable memory, the processor programmed at least to determine from the data inputs corresponding to the patient's blood-glucose-level measurements determined at a plurality of times whether and by how much to vary at least one of the one or more components of the patient's present insulin dosage regimen in order to maintain the patient's future blood-glucose-level measurements within a predefined range; and a display operative to display information corresponding to at least the patient's present insulin dosage regimen.

Abstract: Antenna-plexers for interference cancellation are provided herein. In certain embodiments, a wireless device includes an antenna, an antenna-plexer coupled to the antenna and configured to generate a feedback signal, a transmitter configured to transmit a transmit signal to the antenna by way of the antenna-plexer, a receiver configured to process a receive signal, and a feedback receiver configured to process the feedback signal from the antenna-plexer to provide compensation to the receive signal.

Abstract: An intervertebral implant for implantation in an intervertebral space between vertebrae. The implant includes a body having a front end, a rear end and a pair of spaced apart first and second side walls extending between the front and rear ends. The front and rear ends extend in a transverse direction and a central axis of the body extends from the rear end to the front end. The rear end defines a first fastener hole having a first central axis and a second fastener hole having a second central axis. The first and second central axes extend parallel to one another at an acute angle relative to the body central axis in the transverse direction.

Abstract: A technique for combining first and second images respectively depicting first and second subject matter to facilitate virtual presentation. The first image is processed to identify portions or regions of the first subject matter and determine an estimated depth location of each portion or region. A composite image is generated that depicts the second subject matter overlayed, inserted or otherwise combined with the first subject matter. One or more of the portions or regions of the first subject matter are added, removed, enhanced or modified in the composite image in order to generate a realistic appearance of the first subject matter combined with the second subject matter. The composite image is caused to be displayed as a virtual presentation.

Abstract: A disaggregated routing system is provided for use in a communication network comprising a plurality of white boxes, wherein at least four of the plurality of white boxes are each configured to carry out a functionality different from the functionalities which the other three of the at least four of the plurality of white boxes are configured to carry out, and wherein each of the at least four of the plurality of white boxes is identified based on its functionality.

Abstract: Arrays of optical emitters, modulators, receivers and/or optoelectronic devices used in communication are printed with redundant elements to provide multiple solutions to select from at screening time to improve overall yield. Multiple optoelectronic devices are printed on common chiplets, tightly packed, or printed in sub-arrays.

Abstract: A system, a transportation vehicle, a network component, apparatuses, methods, and computer programs for a transportation vehicle and a network component. The method for a transportation vehicle to determine a route section includes operating the transportation vehicle in an automated driving mode and determining an exceptional traffic situation. The method also includes transmitting information related to the exceptional traffic situation to a network component using a mobile communication system and receiving information related to driving instructions for the route section to overcome the exceptional traffic situation from the network component, wherein the receiving of the driving instructions includes tele-operating the transportation vehicle along the route section to overcome the exceptional traffic situation.

Abstract: Embodiments of the present disclosure include methods and systems of circulating air in an enclosed environment. In such embodiments, the system may comprise an air handling unit (AHU), the AHU including an indoor air inlet to receive an indoor airflow from the enclosed environment and an indoor air outlet to expel the indoor airflow, a conditioning element arranged between the inlet and the outlet configured to at least heat or cool the indoor airflow as it flows thereover, one or more fan units arranged between the inlet and the outlet configured to provide velocity to the indoor airflow, and an air treatment assembly (ATA) arranged within or proximate the AHU, the ATA including an air inlet configured to receive a portion of the indoor airflow received by the AHU indoor air inlet.

Abstract: A hollow core fiber (HCF) link is characterized by structural properties selected to support and sustain light propagation in a fundamental mode and in at least one higher-order mode. Connected to a proximal end of the HCF link, there is a mode coupler configured to couple a data signal into the fundamental mode and to couple an obfuscating signal into the at least one higher-order mode for simultaneous propagation of the data signal and the obfuscating signal on the HCF link, where the obfuscating signal substantially overlaps the data signal in spectral content. At a distal end of the HCF link, there is a mode splitter configured to split a first optical signal detected in the fundamental mode from a second optical signal detected in the at least one higher-order mode.

Abstract: Low glass transition temperature polyamide oligomers or telechelic polyamides are formed from monomers forming amide linkages. These polyamides can be used with co-reactants to form high molecular weight or crosslinked polymers with desirable polyamide properties.