Abstract: Provided are systems and methods for predicting a travel range of a vehicle. The method comprises receiving, using at least one processor, travel information associated with the vehicle, receiving, using the at least one processor, a weather forecast and a traffic forecast associated with the travel information, and predicting, using the at least one processor, the predicted travel range based at least in part on a battery charge level of the vehicle, the weather forecast, and the traffic forecast. In embodiments, the predicted travel range may be based on current and historical battery charge levels, current and/or historical battery discharge rates, weather forecast data, and traffic forecast data.

Abstract: Optimized chimeric antigen receptors (CARs) targeting glypican-2 (GPC2) and having a CD28 hinge region and a CD28 transmembrane domain are described. The antigen-binding domain of the disclosed CARs is derived from GPC2-specific antibody CT3 or humanized versions thereof. The optimized CARs also include an intracellular co-stimulatory domain and an intracellular signaling domain. Immune cells or induced pluripotent stem cells expressing the optimized CARs can be used to treat GPC2-positive solid tumors, such as neuroblastoma.

Abstract: A network interface controller (NIC) capable of efficient operation management for host accelerators is provided. The NIC can be equipped with a host interface and triggering logic block. During operation, the host interface can couple the NIC to a host device. The triggering logic block can obtain, via the host interface from the host device, an operation associated with an accelerator of the host device. The triggering logic block can determine whether a triggering condition has been satisfied for the operation based on an indicator received from the accelerator. If the triggering condition has been satisfied, the triggering logic block can obtain a piece of data generated from the accelerator from a memory location and execute the operation using the piece of data.

Abstract: Systems, devices, and methods for subscription management services including receiving, by a computing device, a message from a message originator user equipment through a messaging service; matching user identification data associated with the received message with an entry in a database; parsing the received message if a match is found; determining whether the parsed message contains a valid request based on the matched user identification data and semantic content of the parsed message; generating a secure service access link based on whether the parsed message is determined to contain a valid request; transmitting the secure service access link through the messaging service to the message originator user equipment; receiving an access response when the secure service access link is accessed by the user equipment; determining if the accessed service access link is valid; and executing the validated request based on whether the service access link is determined to be valid.

Abstract: Systems and methods for providing a customized configuration for a controller of an exoskeleton device. A device can receive, via a user interface, feedback from a user indicative of a performance of the user during a movement event. The device can determine characteristics of the user for performing the movement event using a first exoskeleton boot and a second exoskeleton boot and identify properties of a route for the movement event. The device can determine using the characteristics of the user, the feedback and the properties of the route, control parameters for the first exoskeleton boot and the second exoskeleton boot to execute the movement event. The device can apply the control parameters to the first exoskeleton boot and the second exoskeleton boot for the user to operate the first exoskeleton boot and the second exoskeleton boot during the movement event.

Abstract: A method for generating documentation for a segment of code, comprising executing a code in a development environment for: identifying in a file an updated code segment having a first set of lines, each similar according to at least one text similarity test to one of a second set of lines of a copy of an original code segment that is part of a source documentation object and where the first set of lines is not contiguous in the updated segment and additionally or alternatively the second set of lines is not contiguous in the original segment, by applying the at least one similarity test to at least one original line of the original segment and at least one updated line of the updated segment; and generating an updated source documentation object by modifying the copy of the code segment in the source documentation object according to the updated segment.

Abstract: A router determines whether or not to establish a stateful routing session based on the suitability of one or more candidate return path interfaces. This determination is made when a first packet for a new session arrives at the router on a given ingress interface. For example, the router may be configured to require the ingress interface be used for the return path of the session, and the router may evaluate whether the ingress interface is suitable for the return path and may drop the session if the ingress interface is unsuitable for the return path. In other examples, the router may be configured to not require that the ingress interface be used for the return path, and the router may evaluate whether at least one interface is suitable for the return path and drop the session if no interface is suitable for the return path.

Abstract: Systems and methods for providing ex vivo approximation of micro- and/or nanoparticle oral toxicity in humans include an ex vivo human intestinal model organoid comprising an epithelial layer that separates an apical volume and a basal volume of the ex vivo human intestinal model organoid, a bioreactor for maintaining the ex vivo human intestinal model organoid under physiologically relevant culture conditions, a particle administration inlet adapted to receive a predefined quantity of micro- and/or nanoparticles and to introduce the predefined quantity to the apical volume of the ex vivo human intestinal model organoid according to a predefined dosing regimen, an analytical platform adapted to: interrogate the ex vivo human intestinal model organoid or associated culture media within the bioreactor, and/or to receive and interrogate the ex vivo human intestinal model organoid and/or the associated culture media after removal from the bioreactor, a processor, and a memory.

Abstract: Compounds of formula (I), formula (I), processes for their production and their use as pharmaceuticals.

Abstract: A method includes identifying, by a processing device, a data structure including cells to store data, wherein the cells are arranged within rows and columns of the initial data structure. A scrambled data structure is created in which at least a subset of cells of the initial data structure is rearranged such that each cell of the rearranged subset of cells is located in at least one of a different row or a different column of the initial data structure. Responsive to receiving a user request to access the data of the initial data structure, the processing device determines whether to provide the user with access to the initial data structure or the scrambled data structure.

Abstract: The disclosure pertains to antibodies that bind A-beta oligomers and methods of making and using said antibodies. Also provided are chimeric or humanized antibodies, including antibodies having CDRs in Table 2 and/or having a sequence as set forth in Table 4B or a sequence with at least 50% sequence identity thereto optionally wherein the CDR amino acid sequences are as set for forth in SEQ ID Nos: 74-79. Also provided are methods and uses thereof as well as kits comprising said antibodies.

Abstract: Root-trusted guest memory page management is described. A root-trusted guest is loaded by a hardware platform and authenticated. The root-trusted guest is configured to manage memory operations of different guests via special privileges that permit the root-trusted guest to execute memory operations using a guest's private memory page. To do so, a guest page table includes a novel “T-bit” in each entry, which indicates whether the root-trusted guest or a different guest owns the associated memory page. Each entry in the guest page table for the root-trusted guest additionally includes a “C-bit” that indicates whether the corresponding memory page is a protected page. Combined C-bit and T-bit values for a page table entry dictate whether operations performed as part of handling a guest's memory request are offloaded from the hardware platform to the root-trusted guest.

Abstract: A security framework for virtual machines is described. In one or more implementations, a hardware platform comprises physical computer hardware, the physical computer hardware including one or more processing units and one or more memories. The system also includes a virtual machine monitor configured to virtualize the physical computer hardware of the hardware platform to instantiate a plurality of framework-secure virtual machines. Further, the system includes a root framework-secure virtual machine instantiated by the virtual machine monitor. In accordance with the described techniques, the root framework-secure virtual machine is configured to control access to the hardware platform by the framework-secure virtual machines instantiated by the virtual machine monitor.

Abstract: Methods and compositions for increasing one or more plant growth characteristics in a plant are disclosed. The compositions comprise one or more microbial isolates that promote plant growth. Methods include providing an effective amount of a composition comprising one or more microbial isolates that promote one or more plant growth characteristics.

Abstract: Provided herein are methods and compositions for stabilization of active agents. The active agents are distributed, mixed or embedded in a silk fibroin matrix, thereby retaining the bioactivity of the active agents upon storage and/or transportation. In some embodiments, the storage-stable vaccine-silk compositions are also provided herein.

Abstract: Methods and systems for uneven segmentation of data packets to reduce retransmission penalty accumulated as a result of having to retransmit one or more of the last segments. The method includes segmenting a data packet into segments of different sizes, with generally larger segments in the first half and smaller segments in the second half, and transmitting the segments over an intermediate communication link to another node. The transmission of the segments begins before receiving the entire data packet, and retransmission of a corrupted segment takes place as soon as an indication indicative of the corrupted segment is detected.

Abstract: One or more systems and/or methods for providing conversion prospecting for dynamic content recommendation are provided. A model is trained, using positive events and negative events, to predict conversion-given-click probabilities of users and products. The model is utilized to generate a prediction of a conversion-given-click probability that a user will perform an action in relation to a product. The model is used to generate a bid for the user and the product based upon the conversion-given-click probability, a content provider bid for the product, and a target cost per action. The bid is used to determine whether the product is to compete in an auction hosted by a content serving platform that selects and transmits content items of products to devices for display to users.

Abstract: The invention provides a chemical entity of Formula (I), and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies, detection and imaging techniques, and radioactive treatments; and therapies, including inhibiting PDE4, enhancing neuronal plasticity, treating neurological disorders, providing neuroprotection, treating a cognitive impairment associated with a CNS disorder, enhancing the efficiency of cognitive and motor training, providing neurorecovery and neurorehabilitation, enhancing the efficiency of non-human animal training protocols, and treating treating peripheral disorders, including inflammatory and renal disorders.

Abstract: Methods for identifying sex bias in an association between an omics variant and a disease state are described. The methods may comprise, for example, receiving omics data and clinical data for a plurality of subjects; processing the omics data and clinical data for the plurality of subjects using a model, wherein the model is configured to identify a sex bias in an association between an omics variant identified in the omics data and a disease state identified in the clinical data and output a prediction of whether the omics variant is likely to be a pathogenic variant associated with the disease state based on subject sex; and outputting a prediction of whether the omics variant is likely to be a pathogenic variant associated with the disease state for a subject of known sex.

Abstract: Disclosed are methods for increasing infectivity of entomopathogenic nematodes in any target area for the purposes of insect control, said method comprising: (a) mixing an aqueous nematode infectivity increasing composition with (i) entomopathogenic nematodes to activate said entomopathogenic nematodes for increased infectivity prior to application of said entomopathogenic nematodes to said target area, or (ii) seeds to produce coated seeds, and (b) applying said entomopathogenic nematodes to said target area or planting said coated seeds in said target area; wherein said aqueous nematode infectivity increasing composition is produced by methods disclosed herein.