Abstract: Disclosed are methods for obtaining genome scale and fully phased epigenetic maps in a cell. The method enables maintaining intact chromatin structure and interrogating chromatin structure using chromatin accessibility maps. DNA contacts are used to fully phase the epigenetic and chromatin contact maps.

Abstract: Described herein are fields of exercise or therapy systems in particular exercise or therapy systems that controllably generate and maintain an unweighted environment using a mechanical system or a differential air pressure (DAP) envelope about a user so as to at least partially or completely unweight the user. This application also relates to improved control systems for pressure chambers for use in differential air pressure (DAP) systems including data collection and utilization for general fitness use, athletic use, or medical use treadmills and related software, control and analytics systems, especially as related to obtaining gait data from load cells provided in the system.

Abstract: Various embodiments herein each include at least one of systems, methods, software, and data structures for context-aided machine vision. For example, one method embodiment includes identifying a customer in a shopping area and maintaining an item bin in a computing system of data identifying items the customer has picked up for purchase. This method further includes receiving an image of the customer holding an item and performing item identification processing on the image to identify the item the customer is holding. The item identification processing may be performed based in part on a stored shopping history of the customer indicating items the customer is more likely to purchase. The identified item is then added to the item bin of the customer.

Abstract: A request to activate a service may be received from a user device and a determination may be made as to whether the request is authorized or fraudulent. In particular, a geographical location of the user device may be determined. Whether to activate the service may be determined based on the geographical location of the user device.

Abstract: Disclosed are methods of making a genetically modified immune cell for modifying a tumor microenvironment (TME) and methods of modifying a tumor microenvironment (TME). In some embodiments, the method can include delivering a first vector to an immune cell, wherein the first vector comprises a nucleic acid encoding a protein that induces T-cell proliferation, promotes persistence and activation of endogenous or adoptively transferred NK or T cells and/or induces production of an interleukin, an interferon, a PD-1 checkpoint binding protein, HMGB1, MyD88, a cytokine or a chemokine. Methods of modulating the suppression of the immune response in a tumor microenvironment, minimizing the proliferation of tumor and suppressive cells, and increasing the efficiency of an anti-cancer therapy, anti-infection therapy, antibacterial therapy, anti-viral therapy, or anti-tumoral therapy are also provided.

Abstract: A paper analytical device for detecting an analyte in a sample, and methods of fabricating and using the same. A paper analytical device may include laminated strips of a porous hydrophilic substrate and an adhesive layer. The laminated strips may be disposed on a hydrophobic backing with an air gap barrier between each laminated strip that is about 1 mm to about 5 mm in width and extends along the entire length of the laminated strip. A paper analytical device also may include one or more assay regions having one or more reagents for detecting an analyte, and sample deposition areas for receiving a test sample.

Abstract: The present invention provides EBNA1 inhibitors, and/or pharmaceutical compositions comprising the same, that are useful for the treatment of diseases caused by EBNA1 activity, such as, but not limited to, cancer, infectious mononucleosis, chronic fatigue syndrome, multiple sclerosis, systemic lupus erythematosus and/or rheumatoid arthritis. The present invention further provides EBNA1 inhibitors, and/or pharmaceutical compositions comprising the same, that are useful for the treatment of diseases caused by latent Epstein-Barr Virus (EBV) infection and/or lytic EBV infection.

Abstract: The present invention relates to a nanoparticle and a composition comprising a nanoparticle.

Abstract: A request to activate a service may be received from a user device and a determination may be made as to whether the request is authorized or fraudulent. In particular, a geographical location of the user device may be determined. Whether to activate the service may be determined based on the geographical location of the user device.

Abstract: Disclosed are methods of making a genetically modified immune cell for modifying a tumor microenvironment (TME) and methods of modifying a tumor microenvironment (TME). In some embodiments, the method can include delivering a first vector to an immune cell, wherein the first vector comprises a nucleic acid encoding a protein that induces T-cell proliferation, promotes persistence and activation of endogenous or adoptively transferred NK or T cells and/or induces production of an interleukin, an interferon, a PD-1 checkpoint binding protein, HMGB1, MyD88, a cytokine or a chemokine. Methods of modulating the suppression of the immune response in a tumor microenvironment, minimizing the proliferation of tumor and suppressive cells, and increasing the efficiency of an anti-cancer therapy, anti-infection therapy, antibacterial therapy, anti-viral therapy, or anti-tumoral therapy are also provided.

Abstract: A computer-implemented method for dynamically pricing available storage units based on desirability is described. A server computer accesses a data storage storing a storage unit inventory for a particular facility. Each storage unit in the storage unit inventory is pre-assigned to a pricing group and provided a desirability rank. In response to a trigger for generating an updated sales plan for the particular facility (or for all facilities in a company), the server computer obtains an available storage unit inventory by deducting the unavailable storage units from the storage unit inventory and orders the available storage units within each pricing group by each unit's desirability rank. The server computer then assigns each of the available storage units to one of a plurality of pricing tiers within the pricing group according to the desirability rank order and generates an updated sales plan containing the available storage unit inventory grouped by the pricing group and by the pricing tiers.

Abstract: Systems and methods for setting up live online conversations between people, and selecting participants for such conversations in a manner that optimizes the enjoyment of the participants. Conversations are analyzed and attributes of participants and conversations are extracted from the audio of the conversations. A quality level of the conversations is determined from the audio, and subjective quality assessments may be received from participants. Participants and conversations are divided into classes and clusters, where the classes and clusters represent groups of entities which have certain attributes in common. Based on the attributes, classes, clusters, and quality levels, compatibilities are determined between arbitrary pairs of participants and for arbitrary groups of participants. Conversations are generated, and participants are selected for the conversations based on the determined compatibilities.

Abstract: Methods and systems for evaluating the biomechanical properties of a subject's spine for the purpose of optimizing a potential surgical intervention by selecting or designing surgical hardware fora spinal correction procedure. The system uses a simulated dynamic analysis configured to analyze, predict and improve the outcome of the surgical procedure by taking into account physiological, biomechanical, and anatomical factors. Machine learning algorithms use the computed distribution of forces and moments on the subject's spine, and compare the subject's results with those of patients from a reference population.

Abstract: The ozone spray wand is a portable aqueous ozone generator that is adaptable to fit onto garden hoses, backpack sprayers or any other water supply source. The wand uses electrolytic cells to make ozone on-demand. An operator simply pulls the trigger and a solenoid valve starts delivering ozonated water. Embodiments use a rechargeable battery that allows it to operate for 1 hour between recharge cycles. The wand is rated for 500 hours of use which delivers 15,000 gallons of ozonated water.

Abstract: Pharmaceutical formulations with a tropomyosin-related kinase inhibitor (“Trk inhibitor”) are disclosed. The pharmaceutical formulations comprise 3-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)-6-(1-methyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridin-2-amine in microcrystalline suspension formulations in its monohydrate form, which shows improved characteristics over the anhydrate form, and in extended release formulations. The extended release pharmaceutical formulations comprise 3-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)-6-(1-methyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridin-2-amine-loaded microspheres.

Abstract: The disclosure describes a distributed, pluggable architecture for an artificial reality (AR) system that enables concurrent execution and collaborative scene rendering for multiple artificial reality applications. For example, an AR system includes an image capture device configured to capture image data representative of a physical environment. The AR system also includes a head-mounted display (HMD) configured to output artificial reality content. The AR system further includes a plurality of concurrently executing artificial reality client applications. The AR system also includes a concurrent application engine configured to control rendering the artificial reality content as a common scene that include one or more objects from each of the plurality of artificial reality applications.

Abstract: A system can visually track which items in a store are selected for purchase by a shopper. The system can form a virtual shopping cart by analyzing multiple images, over time, to determine which purchasable items are located with the shopper, such as in a physical shopping cart, in a basket, or held by the shopper. By analyzing multiple images, over time, the system can account for items misidentified in one or more images, or fully or partially obscured in one or more images as the shopper traverses the store. Alternatively, the system can form a virtual shopping cart by analyzing instances in which a purchasable item is removed from a shelf or placed on a shelf. Items removed from, but not returned to, a shelf can be considered to be selected for purchase. The system can include a frictionless checkout that charges the shopper for the selected items.

Abstract: Aspects of this disclosure relate to methods and systems for assessing multifactorial balance health and implementation of a risk alert system. The fall risk information can be used to notify the person and/or a third-party monitoring person (e.g., doctor, physical therapist, personal trainer, etc.) of the person's fall risk. This information may be used to monitor and track changes in fall risk that may be impacted by changes in health status, lifestyle behaviors, or medical treatment. Furthermore, the fall risk classification may help individuals be more careful on the days they are more at risk for falling.

Abstract: The present invention is directed to a process for preparing a compound of formula I-11 through multiple-step reactions: