Abstract: A PCB analysis utilizes manufacturing capability data shared in a multi-tenant collaborative network in a mixed cloud and on-premise environment. Access to a tenant's account of a DFM application deployed on the tenant's premises is provided. The DFM application is enabled to activate the PCB analysis on a DFM profile with manufacturing capability data. The tenant's account requests a utilization authorization of a given DFM profile stored in a cloud data layer. When the utilization is authorized, the given DFM profile is downloaded embedded in a locked DFM envelope, which locks together the given DFM profile with an injected identifier of the authorized tenant's account. Via the DFM application, when logged into the tenant's account, the PCB analysis is activated by permitting the unlocking of the DFM profile from the DFM envelope only when the identifier of the tenant's account is the same as the injected identifier.

Abstract: An elongate delivery shaft assembly (30) includes an outer covering shaft (38) and an inner support shaft (40).

Abstract: An endovascular system includes an elongate delivery shaft assembly, which, when a stent-graft is removably constrained in a radially-compressed delivery state along a distal end portion of the delivery shaft assembly, is shaped so as to define a self-orienting portion, which is shaped so as to define (a) at least proximal and distal curved portions, the proximal curved portion disposed more proximal than the distal curved portion, and (b) at least one point of inflection on a central longitudinal axis of the delivery shaft assembly longitudinally between the proximal and the distal curved portions. Upon positioning of a distal tip of the system near a bifurcation of a brachiocephalic artery from an aortic arch, the self-orienting portion automatically rotationally orients itself in the aortic arch to a rotational orientation in which an inferior lateral opening of the stent-graft faces upstream in the aortic arch. Other embodiments are also described.

Abstract: An elongate delivery shaft assembly (30) includes an outer covering shaft (38) and an inner support shaft (40).

Abstract: A method for treating a subject includes providing an endovascular system that includes a stent-graft and an elongate delivery shaft assembly. When the delivery shaft assembly is unconstrained and the stent-graft is removably constrained along a distal end portion of the delivery shaft assembly, the delivery shaft assembly is shaped so as to define a self-orienting portion, which is shaped so as to define at least proximal and distal curved portions. The delivery shaft assembly is transvascularly introduced into a descending aorta of the subject and a distal end of the delivery shaft assembly is advanced to an aortic arch, such that the self-orienting portion assumes a desired rotational orientation in the aortic arch. While the distal end of the delivery shaft assembly is positioned in the aortic arch, the stent-graft is released from the distal end portion of the delivery shaft assembly. Other embodiments are also described.

Abstract: An endovascular prosthesis includes a stent-graft and an external coagulation inducer. The stent-graft includes a first portion of structural strut members and a first portion of a graft member, which, when the endovascular prosthesis is unconstrained in a radially-expanded state, together are shaped so as to define a blood-carrying tubular structure defining a lumen. The external coagulation inducer includes an extra-luminal skirt, which includes a second portion of the structural strut members and a second portion of the graft member, and is configured to assume: (i) when the endovascular prosthesis is removably disposed in a delivery sheath, a radially-compressed delivery state, in which the structural strut members of the first portion do not coincide with the structural stent members of the second portion, and (ii) when the endovascular prosthesis is unconstrained, a radially-expanded state, in which the extra-luminal skirt extends radially outward from an external surface of the stent-graft.

Abstract: An elongate delivery shaft assembly (30) includes an outer covering shaft (38) and an inner support shaft (40).

Abstract: An endovascular stent-graft (10, 110, 210, 310) is provided that includes elastic struts (20) and a fluid flow guide (30) that is fixed to first and second subsets (32, 34) of the struts (20). The struts (20) of the first subset (32) are arranged as circumferential cells (80) in circumferentially-continuous rings (56), which cause the fluid flow guide (30) to define substantially cylindrical tubular portions (40). The struts (20) of the second subset (34) cause the fluid flow guide (30) to define a bulge (42) having a greatest bulge radius from a central longitudinal axis (38) that is at least 5% greater than an average radius of the substantially cylindrical tubular portions (40) proximally and distally adjacent the bulge (42). The struts (20) of the second subset (34) define tip portions (50).

Abstract: A deployment system (10, 410) includes an inner shaft (36, 436), removably disposed in a self-expanding stent-graft (40), and shaped so as to define (a) at least one conduit therealong (50, 450), which is (i) not coaxial with the inner shaft (36, 436), and (ii) shaped so as to define at least first (52, 452) and second enclosed longitudinal segments (54, 454), and (b) a restraining longitudinal portion (56, 456) that is longitudinally disposed between the first (52, 452) and second enclosed longitudinal segments (54, 454).

Abstract: A method for measuring one-way delays in a communications network, the method comprising: maintaining, at a third node having a reference clock, a first virtual clock state emulating a first node clock located at a first node and a second virtual clock state emulating a second node clock located at a second node; registering a timeset comprising transmission and reception times at the first node and the second node, respectively, for each packet of a plurality of packets that are transmitted from the first node to the second node and reflected from the second node back to the first node; converting times in the timeset, responsive to the first and/or second virtual clocks, into times in accordance with the reference clock; calculating, for each packet of the plurality of packets, a forward one-way delay (FOWD) and a reverse one-way delay (ROWD), responsive to the converted timeset.

Abstract: An endovascular prosthesis includes a stent-graft and an external coagulation inducer. The stent-graft includes a first portion of structural strut members and a first portion of a graft member, which, when the endovascular prosthesis is unconstrained in a radially-expanded state, together are shaped so as to define a blood-carrying tubular structure defining a lumen. The external coagulation inducer includes an extra-luminal skirt, which includes a second portion of the structural strut members and a second portion of the graft member, and is configured to assume: (i) when the endovascular prosthesis is removably disposed in a delivery sheath, a radially-compressed delivery state, in which the structural strut members of the first portion do not coincide with the structural stent members of the second portion, and (ii) when the endovascular prosthesis is unconstrained, a radially-expanded state, in which the extra-luminal skirt extends radially outward from an external surface of the stent-graft.

Abstract: A method for measuring one-way delays in a communications network, the method comprising: maintaining, at a third node having a reference clock, a first virtual clock state emulating a first node clock located at a first node and a second virtual clock state emulating a second node clock located at a second node; registering a timeset comprising transmission and reception times at the first node and the second node, respectively, for each packet of a plurality of packets that are transmitted from the first node to the second node and reflected from the second node back to the first node; converting times in the timeset, responsive to the first and/or second virtual clocks, into times in accordance with the reference clock; calculating, for each packet of the plurality of packets, a forward one-way delay (FOWD) and a reverse one-way delay (ROWD), responsive to the converted timeset.

Abstract: An elongate delivery shaft assembly (30) includes an outer covering shaft (38) and an inner support shaft (40).

Abstract: A method for measuring one-way delays in a communications network, the method comprising: maintaining a virtual clock state comprising information for converting times measured with respect to remote clocks into times as would be measured with respect to a local reference clock; registering, for each packet of the plurality of packets in a communications session between the first and second nodes, a timeset comprising transmission and reception times at the first and second nodes; converting, responsive to the virtual clock, times in the timeset measured with respect to the first node clock or the second node clock, into times as would be measured with respect to the reference clock; calculating, for each packet of the series of packets, a forward one-way delay (FOWD) from the first node to the second node and a reverse one-way delay (ROWD) from the second node to the first node, responsive to the converted timeset.

Abstract: Apparatus for synchronizing a local clock to a master clock, the apparatus comprising: at least one port for receiving and transmitting packets; a local clock; and a packet inspector that uses time from the local clock to timestamp packets received at a port of the at least one port, copies timing information from the received packets if the packets are timing distribution packets that are transmitted between a master clock and a slave clock in order to synchronize the slave clock to the master clock, and forwards the received packets for transmission from a port of the at least one port towards a packet destination that is not a packet source from where the packets originate, wherein the local clock uses the copied timing information and timestamps to synchronize the local clock to the master clock.

Abstract: A deployment system (10, 410) includes an inner shaft (36, 436), removably disposed in a self-expanding stent-graft (40), and shaped so as to define (a) at least one conduit therealong (50, 450), which is (i) not coaxial with the inner shaft (36, 436), and (ii) shaped so as to define at least first (52, 452) and second enclosed longitudinal segments (54, 454), and (b) a restraining longitudinal portion (56, 456) that is longitudinally disposed between the first (52, 452) and second enclosed longitudinal segments (54, 454).

Abstract: Apparatus for synchronizing a local clock to a master clock, the apparatus comprising: at least one port for receiving and transmitting packets; a local clock; and a packet inspector that uses time from the local clock to timestamp packets received at a port of the at least one port, copies timing information from the received packets if the packets are timing distribution packets that are transmitted between a master clock and a slave clock in order to synchronize the slave clock to the master clock, and forwards the received packets for transmission from a port of the at least one port towards a packet destination that is not a packet source from where the packets originate, wherein the local clock uses the copied timing information and timestamps to synchronize the local clock to the master clock.

Abstract: Apparatus for monitoring a packet switched network, the apparatus comprising: at least one port for receiving and transmitting packets; a local clock; and a packet inspector that uses time from the local clock to timestamp packets received at a port of the at least one port, and additionally copies timing information from received timing distribution packets, which are transmitted from a master clock to a slave clock in order to discipline the slave clock, and forwards the received packets for transmission from a port of the at least one port; wherein the apparatus uses the timestamp of a received timing distribution packet and the copied timing information to monitor timing distribution performance of the network.

Abstract: Apparatus for monitoring a packet switched network, the apparatus comprising: at least one port for receiving and transmitting packets; a local clock; and a packet inspector that uses time from the local clock to timestamp packets received at a port of the at least one port, and additionally copies timing information from received timing distribution packets, which are transmitted from a master clock to a slave clock in order to discipline the slave clock, and forwards the received packets for transmission from a port of the at least one port; wherein the apparatus uses the timestamp of a received timing distribution packet and the copied timing information to monitor timing distribution performance of the network .

Abstract: Molecularly imprinted smart polymers (MISPs) are provided herein, as well as novel monomers for preparing MISPs, and processes for preparing MISPs. The MISPs can be used applications such as, for example, detecting/absorbing or isolating biological and non-biological agents. The MISPs described herein comprise responsive monomeric units which undergo a physico-chemical change (e.g., a bond formation or cleavage) in response to an external change, such that the MISP selectively binds to a target molecule and releases a bound target molecule in response to the external change.