Abstract: Systems including apparatus, methods, compositions, and kits for multiplexed analysis of biological systems using nonpositional and/or positional arrays of coded carriers.

Abstract: Systems, including apparatus and methods, for performing assays with adjustable fluid communication between samples.

Abstract: Systems, including methods, apparatus, compositions, and kits, for multiplexed assay of cell migration with subdivided cell holders and/or microplates.

Abstract: Systems, including apparatus and methods, for performing assays with adjustable fluid communication between samples.

Abstract: Systems, including methods, apparatus, compositions, and kits, for multiplexed assay of cell migration with subdivided cell holders and/or microplates.

Abstract: Systems for multiplexed analysis of gene expression using coded RNA reporters. The coded RNA reporters are expressed from a library of reporter genes, with each reporter gene directing expression of a distinguishable coded RNA reporter. Each RNA reporter thus reports activity of a corresponding reporter gene. The distinguishable reporter RNA species allow otherwise similar reporter genes to be functionally linked to different effectors within a cell reporter library. Multiplexed analysis of reporter gene activity is carried out by measuring the level of each RNA reporter within the cell reporter library, thus providing an ability to analyze the effect of a biological modulator on many effectors.

Abstract: Assay systems that sense assay conditions using coded sensor particles.

Abstract: Systems, including methods, apparatus, compositions, and kits, for multiplexed analysis of different cell populations to measure a set of responses generated by the cell populations upon exposure to a condition in a shared fluid volume, to define a selective effect, if any, of the condition. The invention also provides databases that relate sets of responses measured from multiplexed analysis of cell populations in a plurality of shared fluid volumes to different conditions that generated each set of responses.

Abstract: Systems, including methods, compositions, and kits, for transfection of cells with transfection materials using coded carriers.

Abstract: The invention provides systems, including methods, apparatus, compositions, and kits, for connection of cells or cell structures to substrates, such as coded particles or microplates, utilizing association pairs that are chemically reactive or specifically bind one another.

Abstract: System, including methods and compositions, for multiplexed analysis of cellular responses using endogenous, response-selective reporter genes.

Abstract: Systems, including methods, compositions, and kits, for multiplexed analysis of interactions between cells and substrates using coded carriers.

Abstract: Systems, including apparatus and methods, for performing assays in which two or more samples may be held in or out of simultaneous contact with the same fluid environment.

Abstract: Systems for multiplexed analysis of gene expression using coded RNA reporters. The coded RNA reporters are expressed from a library of reporter genes, with each reporter gene directing expression of a distinguishable coded RNA reporter. Each RNA reporter thus reports activity of a corresponding reporter gene. The distinguishable reporter RNA species allow otherwise similar reporter genes to be functionally linked to different effectors within a cell reporter library. Multiplexed analysis of reporter gene activity is carried out by measuring the level of each RNA reporter within the cell reporter library, thus providing an ability to analyze the effect of a biological modulator on many effectors.

Abstract: Systems including apparatus, methods, compositions, and kits for multiplexed analysis of biological systems using nonpositional and/or positional arrays of coded carriers.