Patents by Inventor Oren Ram
Oren Ram has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240093694Abstract: A well pumping apparatus including a discharge head (110), a drive string rod (130) in fluid communication with an inner cavity (142) of a production tubing (140), a pre-lubrication port (160) at the discharge head, and lubrication cups (134) installed along the drive string rod adjacent to sets of bearings (150) distributed along the drive string rod.Type: ApplicationFiled: April 12, 2022Publication date: March 21, 2024Inventors: Benjamin EILAN, Boris POLYAK, Nadav DARF, Alex KATZ, Oren RAM
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Publication number: 20210355535Abstract: The present invention generally relates to microfluidics and/or epigenetic sequencing. In one set of embodiments, cells contained within a plurality of microfluidic droplets are lysed and the DNA (e.g., from nucleosomes) within the droplets are labeled, e.g., with adapters containing an identification sequence. The adapters may also contain other sequences, e.g., restriction sites, primer sites, etc., to assist with later analysis. After labeling with adapters, the DNA from the different cells may be combined and analyzed, e.g., to determine epigenetic information about the cells. For example, the DNA may be separated on the basis of certain modifications (e.g., methylation), and the DNA from the separated nucleosomes may be sequenced using techniques such as chromatin immunoprecipitation (“CUP”). In some cases, the DNA sequences may also be aligned with genomes, e.g., to determine which portions of the genome were epigenetically modified, e.g., via methylation.Type: ApplicationFiled: May 25, 2021Publication date: November 18, 2021Applicants: President and Fellows of Harvard College, The General Hospital CorporationInventors: David Weitz, Assaf Rotem, Oren Ram, Bradley E. Bernstein
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Patent number: 11047003Abstract: The present invention generally relates to microfluidics and/or epigenetic sequencing. In one set of embodiments, cells contained within a plurality of microfluidic droplets are lysed and the DNA (e.g., from nucleosomes) within the droplets are labeled, e.g., with adapters containing an identification sequence. The adapters may also contain other sequences, e.g., restriction sites, primer sites, etc., to assist with later analysis. After labeling with adapters, the DNA from the different cells may be combined and analyzed, e.g., to determine epigenetic information about the cells. For example, the DNA may be separated on the basis of certain modifications (e.g., methylation), and the DNA from the separated nucleosomes may be sequenced using techniques such as chromatin immunoprecipitation (“ChIP”). In some cases, the DNA sequences may also be aligned with genomes, e.g., to determine which portions of the genome were epigenetically modified, e.g., via methylation.Type: GrantFiled: August 7, 2017Date of Patent: June 29, 2021Assignees: The General Hospital Corporation, President and Fellows of Harvard CollegeInventors: Assaf Rotem, Oren Ram, Bradley E. Bernstein, David A. Weitz
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Patent number: 11001883Abstract: The present invention generally relates to microfluidics and/or epigenetic sequencing. In one set of embodiments, cells contained within a plurality of microfluidic droplets are lysed and the DNA (e.g., from nucleosomes) within the droplets are labeled, e.g., with adapters containing an identification sequence. The adapters may also contain other sequences, e.g., restriction sites, primer sites, etc., to assist with later analysis. After labeling with adapters, the DNA from the different cells may be combined and analyzed, e.g., to determine epigenetic information about the cells. For example, the DNA may be separated on the basis of certain modifications (e.g., methylation), and the DNA from the separated nucleosomes may be sequenced using techniques such as chromatin immunoprecipitation (“ChIP”). In some cases, the DNA sequences may also be aligned with genomes, e.g., to determine which portions of the genome were epigenetically modified, e.g., via methylation.Type: GrantFiled: September 5, 2014Date of Patent: May 11, 2021Assignees: The General Hospital Corporation, President and Fellows of Harvard CollegeInventors: Assaf Rotem, Oren Ram, Bradley E. Bernstein, David A. Weitz
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Patent number: 10718236Abstract: A turbine shaft bearing apparatus in a turbine module includes two axially spaced turbine shaft bearings, including an outlet side bearing protected from overheating by a solid bearing housing which surrounds the outlet side bearing. The bearing housing being provided with a support including conduit for a lubricating medium. The turbine module has plurality of axially spaced turbine wheels connected to a common turbine shaft and coaxial therewith; an inlet through which motive fluid vapor is introduced to a first stage of the turbine wheels; a structured bleeding exit opening formed in an outer turbine casing of the turbine module; and a passage defined between two of the turbine wheels and in fluid communication with the bleeding exit opening, wherein expanded motive fluid vapor may be extracted through the structured bleeding exit opening and supplied to a heat exchange component for heating the motive fluid condensate.Type: GrantFiled: September 19, 2016Date of Patent: July 21, 2020Assignee: ORMAT TECHNOLOGIES, INC.Inventors: Dany Batscha, Oren Ram, Anton Fiterman, Ran Reshef, Herzel Sharoni, Uri Kaplan
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Publication number: 20180265922Abstract: The present invention generally relates to microfluidics and/or epigenetic sequencing. In one set of embodiments, cells contained within a plurality of microfluidic droplets are lysed and the DNA (e.g., from nucleosomes) within the droplets are labeled, e.g., with adapters containing an identification sequence. The adapters may also contain other sequences, e.g., restriction sites, primer sites, etc., to assist with later analysis. After labeling with adapters, the DNA from the different cells may be combined and analyzed, e.g., to determine epigenetic information about the cells. For example, the DNA may be separated on the basis of certain modifications (e.g., methylation), and the DNA from the separated nucleosomes may be sequenced using techniques such as chromatin immunoprecipitation (“ChIP”). In some cases, the DNA sequences may also be aligned with genomes, e.g., to determine which portions of the genome were epigenetically modified, e.g., via methylation.Type: ApplicationFiled: April 27, 2018Publication date: September 20, 2018Inventors: David A. Weitz, Assaf Rotem, Oren Ram, Bradley E. Bernstein
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Publication number: 20180155777Abstract: The present invention generally relates to microfluidics and/or epigenetic sequencing. In one set of embodiments, cells contained within a plurality of microfluidic droplets are lysed and the DNA (e.g., from nucleosomes) within the droplets are labeled, e.g., with adapters containing an identification sequence. The adapters may also contain other sequences, e.g., restriction sites, primer sites, etc., to assist with later analysis. After labeling with adapters, the DNA from the different cells may be combined and analyzed, e.g., to determine epigenetic information about the cells. For example, the DNA may be separated on the basis of certain modifications (e.g., methylation), and the DNA from the separated nucleosomes may be sequenced using techniques such as chromatin immunoprecipitation (“ChIP”). In some cases, the DNA sequences may also be aligned with genomes, e.g., to determine which portions of the genome were epigenetically modified, e.g., via methylation.Type: ApplicationFiled: December 8, 2017Publication date: June 7, 2018Inventors: David A. Weitz, Assaf Rotem, Oren Ram, Bradley E. Bernstein
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Publication number: 20180155778Abstract: The present invention generally relates to microfluidics and/or epigenetic sequencing. In one set of embodiments, cells contained within a plurality of microfluidic droplets are lysed and the DNA (e.g., from nucleosomes) within the droplets are labeled, e.g., with adapters containing an identification sequence. The adapters may also contain other sequences, e.g., restriction sites, primer sites, etc., to assist with later analysis. After labeling with adapters, the DNA from the different cells may be combined and analyzed, e.g., to determine epigenetic information about the cells. For example, the DNA may be separated on the basis of certain modifications (e.g., methylation), and the DNA from the separated nucleosomes may be sequenced using techniques such as chromatin immunoprecipitation (“ChIP”). In some cases, the DNA sequences may also be aligned with genomes, e.g., to determine which portions of the genome were epigenetically modified, e.g., via methylation.Type: ApplicationFiled: December 8, 2017Publication date: June 7, 2018Inventors: David A. Weitz, Assaf Rotem, Oren Ram, Bradley E. Bernstein
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Publication number: 20180080341Abstract: The present invention provides a turbine shaft bearing apparatus, comprising two axially spaced, inlet side and outlet side bearings for providing support to a turbine shaft to which are connected a plurality of turbine wheels such that the turbine shaft, the two spaced bearings, and the plurality of turbine wheels are all coaxial, wherein the outlet side bearing is protected from overheating by motive fluid expanded by one or more of the plurality of turbine wheels or stages by a solid bearing housing which surrounds the outlet side bearing which is supported and provided with a conduit through which a lubricating medium for lubricating said outlet side bearing is supplied from a port external to said turbine.Type: ApplicationFiled: September 19, 2016Publication date: March 22, 2018Applicant: ORMAT TECHNOLOGIES, Inc.Inventors: Dany BATSCHA, Oren RAM, Anton FITERMAN, Ran RESHEF, Herzel SHARONI, Uri KAPLAN
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Publication number: 20180023133Abstract: The present invention generally relates to microfluidics and/or epigenetic sequencing. In one set of embodiments, cells contained within a plurality of microfluidic droplets are lysed and the DNA (e.g., from nucleosomes) within the droplets are labeled, e.g., with adapters containing an identification sequence. The adapters may also contain other sequences, e.g., restriction sites, primer sites, etc., to assist with later analysis. After labeling with adapters, the DNA from the different cells may be combined and analyzed, e.g., to determine epigenetic information about the cells. For example, the DNA may be separated on the basis of certain modifications (e.g., methylation), and the DNA from the separated nucleosomes may be sequenced using techniques such as chromatin immunoprecipitation (“ChIP”). In some cases, the DNA sequences may also be aligned with genomes, e.g., to determine which portions of the genome were epigenetically modified, e.g., via methylation.Type: ApplicationFiled: August 7, 2017Publication date: January 25, 2018Inventors: Assaf Rotem, Oren Ram, Bradley E. Bernstein, David A. Weitz
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Publication number: 20160208323Abstract: Disclosed are methods for shearing and tagging chromatin DNA. The disclosed methods include contacting chromatin DNA with at least one transposome, that includes a transposase enzyme. The transposon is made up of a first DNA molecule that includes a first transposase recognition site and a second DNA molecule that includes a second transposase recognition site, wherein the transposase integrates the first and second DNA molecules into chromatin DNA. The first and second DNA molecules of the transposon can be disconnected, such that upon integration of the transposon the chromatin bound DNA is sheared and tagged with the first and second DNA molecules, for example to prepare a library of sheared and tagged chromatin DNA fragments.Type: ApplicationFiled: June 19, 2014Publication date: July 21, 2016Inventors: Bradley BERNSTEIN, Alon GOREN, Chad NUSBAUM, Oren RAM, Assaf ROTEM, Daniel TARJAN, Jeffrey XING, Aviv REGEV
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Publication number: 20150057163Abstract: The present invention generally relates to microfluidics and/or epigenetic sequencing. In one set of embodiments, cells contained within a plurality of microfluidic droplets are lysed and the DNA (e.g., from nucleosomes) within the droplets are labeled, e.g., with adapters containing an identification sequence. The adapters may also contain other sequences, e.g., restriction sites, primer sites, etc., to assist with later analysis. After labeling with adapters, the DNA from the different cells may be combined and analyzed, e.g., to determine epigenetic information about the cells. For example, the DNA may be separated on the basis of certain modifications (e.g., methylation), and the DNA from the separated nucleosomes may be sequenced using techniques such as chromatin immunoprecipitation (“ChIP”). In some cases, the DNA sequences may also be aligned with genomes, e.g., to determine which portions of the genome were epigenetically modified, e.g., via methylation.Type: ApplicationFiled: September 5, 2014Publication date: February 26, 2015Inventors: Assaf Rotem, Oren Ram, Bradley E. Bernstein, David A. Weitz