Patents by Inventor Orhun Muratoglu

Orhun Muratoglu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190167852
    Abstract: Systems and methods of protecting allograft against radiation damage are disclosed. Systems and methods of incorporating additives such as radioprotectants into allograft tissue are also disclosed. The systems and methods comprise providing an allograft; cleaning the allograft; contacting the allograft with at least one radioprotectant, thereby obtaining a radioprotectant-doped allograft; contacting the radioprotectant-doped allograft with a supercritical fluid, thereby obtaining a radioprotectant doped and homogenized allograft.
    Type: Application
    Filed: April 17, 2017
    Publication date: June 6, 2019
    Applicant: The General Hospital Corporation
    Inventors: Ebru ORAL, Jeremy SUHARDI, Orhun MURATOGLU
  • Publication number: 20180207315
    Abstract: Provided is a method of making a polymeric material with a spatially controlled distribution of one or more additives including the steps of blending the one or more additives with a polymeric material, consolidating the polymeric material, heating at least a portion of at least one surface of the consolidated additive-blended polymeric material, and cooling the heated consolidated additive-blended polymeric material, thereby forming a polymeric material with a spatially controlled distribution of additive.
    Type: Application
    Filed: January 30, 2018
    Publication date: July 26, 2018
    Inventors: Ebru Oral, Chhavi Gupta, Orhun Muratoglu
  • Patent number: 10000305
    Abstract: Methods of making a wear and oxidation resistant medical implant are disclosed.
    Type: Grant
    Filed: May 9, 2013
    Date of Patent: June 19, 2018
    Assignee: The General Hospital Corporation
    Inventors: Ebru Oral, Orhun Muratoglu
  • Patent number: 9889224
    Abstract: Provided is a method of making a polymeric material with a spatially controlled distribution of one or more additives including the steps of blending the one or more additives with a polymeric material, consolidating the polymeric material, heating at least a portion of at least one surface of the consolidated additive-blended polymeric material, and cooling the heated consolidated additive-blended polymeric material, thereby forming a polymeric material with a spatially controlled distribution of additive.
    Type: Grant
    Filed: August 2, 2013
    Date of Patent: February 13, 2018
    Assignee: The General Hospital Corporation
    Inventors: Ebru Oral, Chhavi Gupta, Orhun Muratoglu
  • Patent number: 9289302
    Abstract: Various embodiments of mosaicplasty constructs and methods for implanting the constructs into anatomical structures. The mosaicplasty constructs may be formed from artificial materials and may include a hard articulating portion and a relatively softer elastic, support portion. The mosaicplasty constructs may include bone ingrowth materials to facilitate ingrowth of bone and other tissues into the construct. The mosaicplasty constructs may also be at least partially formed of hydrogel materials.
    Type: Grant
    Filed: July 20, 2009
    Date of Patent: March 22, 2016
    Assignee: Zimmer, Inc.
    Inventors: Brian H. Thomas, Steven J. Charlebois, Donald Yakimicki, James Mason, Stephen H. Spiegelberg, Gavin Braithwaite, Gareth McKinley, Orhun Muratoglu
  • Publication number: 20150190545
    Abstract: Provided is a method of making a polymeric material with a spatially controlled distribution of one or more additives including the steps of blending the one or more additives with a polymeric material, consolidating the polymeric material, heating at least a portion of at least one surface of the consolidated additive-blended polymeric material, and cooling the heated consolidated additive-blended polymeric material, thereby forming a polymeric material with a spatially controlled distribution of additive.
    Type: Application
    Filed: August 2, 2013
    Publication date: July 9, 2015
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Ebru Oral, Chhavi Gupta, Orhun Muratoglu
  • Publication number: 20150151866
    Abstract: Methods of making a wear and oxidation resistant medical implant are disclosed.
    Type: Application
    Filed: May 9, 2013
    Publication date: June 4, 2015
    Inventors: Ebru Oral, Orhun Muratoglu
  • Patent number: 8563623
    Abstract: A medical prosthesis for use within the body which is formed of radiation treated ultra high molecular weight polyethylene having substantially no detectable free radicals, is described. Preferred prostheses exhibit reduced production of particles from the prosthesis during wear of the prosthesis, and are substantially oxidation resistant. Methods of manufacture of such devices and material used therein are also provided.
    Type: Grant
    Filed: December 8, 2004
    Date of Patent: October 22, 2013
    Assignees: The General Hospital Corporation, Massachusetts Institute of Technology
    Inventors: Edward W. Merrill, William H. Harris, Murali Jasty, Orhun Muratoglu, Charles R. Bragdon, Daniel O. O'Connor, Premnath Venugopalan
  • Publication number: 20120060852
    Abstract: A medical prosthesis for use within the body which is formed of radiation treated ultra high molecular weight polyethylene having substantially no detectable free radicals, is described. Preferred prostheses exhibit reduced production of particles from the prosthesis during wear of the prosthesis, and are substantially oxidation resistant. Methods of manufacture of such devices and material used therein are also provided.
    Type: Application
    Filed: November 14, 2011
    Publication date: March 15, 2012
    Applicants: Massachusetts Institute of Technology, The General Hospital Corporation
    Inventors: Edward W. Merrill, William H. Harris, Murali Jasty, Orhun Muratoglu, Charles R. Bragdon, Daniel O. O'Connor, Premnath Venugopalan
  • Publication number: 20120016051
    Abstract: A medical prosthesis for use within the body which is formed of radiation treated ultra high molecular weight polyethylene having substantially no detectable free radicals, is described. Preferred prostheses exhibit reduced production of particles from the prosthesis during wear of the prosthesis, and are substantially oxidation resistant. Methods of manufacture of such devices and material used therein are also provided.
    Type: Application
    Filed: December 23, 2010
    Publication date: January 19, 2012
    Applicants: Massachusetts Institute of Technology, The General Hospital Corporation
    Inventors: Eward W. Merrill, William H. Harris, Murali Jasty, Orhun Muratoglu, Charles R. Bragdon, Daniel O. O'Connor, Premnath Venugopalan
  • Patent number: 7858671
    Abstract: A medical prosthesis for use within the body which is formed of radiation treated ultra high molecular weight polyethylene having substantially no detectable free radicals, is described. Preferred prostheses exhibit reduced production of particles from the prosthesis during wear of the prosthesis, and are substantially oxidation resistant. Methods of manufacture of such devices and material used therein are also provided.
    Type: Grant
    Filed: July 29, 2004
    Date of Patent: December 28, 2010
    Assignees: The General Hospital Corporation, Massachusetts Institute of Technology
    Inventors: Edward W. Merrill, William H. Harris, Murali Jasty, Orhun Muratoglu, Charles R. Bragdon, Daniel O. O'Connor, Premnath Venugopalan
  • Publication number: 20100161073
    Abstract: Various embodiments of mosaicplasty constructs and methods for implanting the constructs into anatomical structures. The mosaicplasty constructs may be formed from artificial materials and may include a hard articulating portion and a relatively softer elastic, support portion. The mosaicplasty constructs may include bone ingrowth materials to facilitate ingrowth of bone and other tissues into the construct. The mosaicplasty constructs may also be at least partially formed of hydrogel materials.
    Type: Application
    Filed: July 20, 2009
    Publication date: June 24, 2010
    Applicant: ZIMMER, INC.
    Inventors: Brian H. Thomas, Steven J. Charlebois, Donald Yakimicki, James Mason, Stephen H. Spiegelberg, Gavin Braithwaite, Gareth McKinley, Orhun Muratoglu
  • Publication number: 20090105364
    Abstract: A medical prosthesis for use within the body which is formed of radiation treated ultra high molecular weight polyethylene having substantially no detectable free radicals, is described. Preferred prostheses exhibit reduced production of particles from the prosthesis during wear of the prosthesis, and are substantially oxidation resistant. Methods of manufacture of such devices and material used therein are also provided.
    Type: Application
    Filed: December 12, 2008
    Publication date: April 23, 2009
    Applicants: The General Hospital Corporation, Massachusetts Institute of Technology
    Inventors: Edward W. Merrill, William H. Harris, Murali Jasty, Orhun Muratoglu, Charles R. Bragdon, Daniel O. O'Connor, Premnath Venugopalan
  • Publication number: 20080090933
    Abstract: The present invention provides an irradiated crosslinked polyethylene containing reduced free radicals, preferably containing substantially no residual free radical. Disclosed is a process of making irradiated crosslinked polyethylene by irradiating the polyethylene in contact with a sensitizing environment at an elevated temperature that is below the melting point, in order to reduce the concentration of residual free radicals to an undetectable level. A process of making irradiated crosslinked polyethylene composition having reduced free radical content, preferably containing substantially no residual free radicals, by mechanically deforming the polyethylene at a temperature that is below the melting point of the polyethylene, optionally in a sensitizing environment, is also disclosed herein.
    Type: Application
    Filed: October 17, 2007
    Publication date: April 17, 2008
    Applicants: Massachusetts General Hospital, Cambridge Polymer Group, Inc.
    Inventors: Orhun Muratoglu, Stephen Spiegelberg, Gareth McKinley
  • Publication number: 20080090934
    Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion, post-doping annealing, and materials used therein.
    Type: Application
    Filed: November 30, 2007
    Publication date: April 17, 2008
    Applicants: The General Hospital Corporation dba Massachusetts General Hospital, Cambridge Polymer Group, Inc.
    Inventors: Orhun Muratoglu, Stephen Spiegelberg
  • Publication number: 20080067724
    Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.
    Type: Application
    Filed: November 30, 2007
    Publication date: March 20, 2008
    Applicants: Massachusetts General Hospital, Cambridge Polymer Group, Inc.
    Inventors: Orhun MURATOGLU, Stephen Spiegelberg
  • Publication number: 20080039545
    Abstract: The present invention provides an irradiated crosslinked polyethylene containing reduced free radicals, preferably containing substantially no residual free radical. Disclosed is a process of making irradiated crosslinked polyethylene by irradiating the polyethylene in contact with a sensitizing environment at an elevated temperature that is below the melting point, in order to reduce the concentration of residual free radicals to an undetectable level. A process of making irradiated crosslinked polyethylene composition having reduced free radical content, preferably containing substantially no residual free radicals, by mechanically deforming the polyethylene at a temperature that is below the melting point of the polyethylene, optionally in a sensitizing environment, is also disclosed herein.
    Type: Application
    Filed: October 17, 2007
    Publication date: February 14, 2008
    Applicants: Massachusetts General Hospital, Cambridge Polymer Group, Inc.
    Inventors: Orhun MURATOGLU, Stephen Spielgelberg, Gareth McKinley
  • Publication number: 20070267030
    Abstract: The present invention relates to methods for making highly crystalline polymeric material, for example, highly crystalline cross-linked and not cross-linked ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making additive-doped highly crystalline polymeric material using high pressure and high temperature crystallization processes, medical implants made thereof, and materials used therein.
    Type: Application
    Filed: April 24, 2007
    Publication date: November 22, 2007
    Applicant: The General Hospital Corporation dba Massachusetts General Hospital
    Inventors: Orhun MURATOGLU, Ebru Oral
  • Publication number: 20070265369
    Abstract: The present invention relates to methods for making highly crystalline cross-linked polymeric material, for example, highly crystalline cross-linked ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped highly crystalline cross-linked polymeric material using high pressure and high temperature crystallization processes, medical implants made thereof, and materials used therein.
    Type: Application
    Filed: February 3, 2005
    Publication date: November 15, 2007
    Applicant: The General Hospital DBA Massachusetts General Hospital
    Inventors: Orhun Muratoglu, Ebru Oral
  • Publication number: 20070191504
    Abstract: The present invention provides partial and complete shielding approaches to alter the cross-linking characteristics of irradiated polymers, such as polyethylene. Irradiated polymers and fabricated articles, such as medical prosteses, comprising irradiated polymers also are provided.
    Type: Application
    Filed: March 27, 2007
    Publication date: August 16, 2007
    Applicant: Massachusetts General Hospital
    Inventor: Orhun MURATOGLU