Abstract: The present invention provides dioxetane-based chemiluminescence probes, more specifically fluorophore-tethered dioxetane-based chemiluminescence probes and compositions thereof. The chemiluminescence probes disclosed are useful for both diagnostics and in vivo imaging.

Abstract: The present invention relates to a sensing method to specifically detect, measure and/or monitor carbon dioxide. It further relates to a probe adapted to specifically sense the carbon dioxide. The probe is of formula (I?) Wherein Dy is dye moiety, Preact is a reactive part to carbon dioxide and L is a spacer. The present invention also relates to a kit specifically adapted to sense, detect and/or measure the carbon dioxide.

Abstract: The present invention provides dioxctane-based chemiluminescence probes, more specifically fluorophore-tethered dioxctane-based chemiluminescence probes and compositions thereof. The chemiluminescence probes disclosed are useful for both diagnostics and in vivo imaging.

Abstract: The present invention provides dioxetane-based chemiluminescence probes, more specifically fluorophore-tethered dioxetane-based chemiluminescence probes and compositions thereof. The chemiluminescence probes disclosed are useful for both diagnostics and in vivo imaging.

Abstract: A method is for the detection of presence or absence, quantification, and identification of target microorganisms, such as bacteria, bacterial fragments (e.g., LPS, endotoxin), viruses, fungi as well as other pathogens by means of chemiluminescence. The method include providing a medium with one or more target analytes, target microorganisms or target metabolites, adding a dioxetane compound to the medium so that the dioxetane compound emits light, and detecting the emitted light.

Abstract: Dioxetane compounds represented by Formula I below, and methods of using the dioxetane compounds in the detection of presence or absence, quantification, and identification of microorganisms including bacteria, bacterial fragments (e.g., LPS, endotoxin), viruses, and fungi by means of chemiluminescence.

Abstract: Turn-ON dioxetane-based chemiluminescence probes based on the Schapp's adamantylidene-dioxetane probe eh are useful for determining the presence, or measuring the level, of Mycobacterium tuberculosis (Mtb)-specific protease in a sample, and for assessing the susceptibility of the Mtb to an antibiotic drug. determining the presence or measuring the level of Mycobacterium tuberculosis (Mtb)-specific protease in the sample can include contacting the sample with a certain compound, and imaging the sample to detect an emission of light.

Abstract: The present invention provides dioxetane-based chemiluminescence probes, more specifically fluorophore-tethered dioxetane-based chemiluminescence probes and compositions thereof. The chemiluminescence probes disclosed are useful for both diagnostics and in vivo imaging.

Abstract: The present invention provides turn-ON dioxetane-based chemiluminescence probes based on the Schapp's adamantylidene-dioxetane probe, which emit light in the near-infrared (NIR) region and are therefore useful for in vivo imaging, as well as compositions and uses thereof.

Abstract: The present invention provides dioxetane-based chemiluminescence probes, more specifically fluorophore-tethered dioxetane-based chemiluminescence probes and compositions thereof. The chemiluminescence probes disclosed are useful for both diagnostics and in vivo imaging.

Abstract: Improved long wavelength-emitting chemiluminescent probes are easy to synthesize and are well-suited for both in vitro and in vivo applications, but are particularly well-suited for in vivo applications. The wavelengths of the emissions of the probes include those in the orange, red or NIR range. Dioxetane compounds and phenolic ester compounds are included.

Abstract: Dioxetane compounds can be used in the detection of presence or absence, quantification and identification of microorganisms including bacteria, bacterial fragments (e.g., LPS, endotoxin), viruses, fungi as well as other pathogens by means of chemiluminescence and to corresponding methods. A method for the detection of a target analyte, a target microorganism or a target metabolite includes providing a medium including one or more target analytes, target microorganisms or target metabolites, adding a dioxetane compound to the medium so that the compound emits light, and detecting the emitted light.

Abstract: The present invention provides dioxetane-based chemiluminescence probes, more specifically fluorophore-tethered dioxetane-based chemiluminescence probes and compositions thereof. The chemiluminescence probes disclosed are useful for both diagnostics and in vivo imaging.

Abstract: Dioxetane-based chemiluminescence probes, more specifically fluorophore-tethered dioxetane-based chemiluminescence probes and ?* acceptor group-containing dioxetane based chemiluminescence probes can be included in compositions. The chemiluminescence probes are useful for both diagnostics and in vivo imaging.

Abstract: The present invention provides turn-ON dioxetane-based chemiluminescence probes based on the Schapp's adamantylidene-dioxetane probe, which emit light in the near-infrared (NIR) region and are therefore useful for in vivo imaging, as well as compositions and uses thereof.

Abstract: Dioxetane-based chemiluminescence probes, more specifically fluorophore-tethered dioxetane-based chemiluminescence probes and ?* acceptor group-containing dioxetane based chemiluminescence probes can be included in compositions. The chemiluminescence probes are useful for both diagnostics and in vivo imaging.