Patents by Inventor Orit Braha

Orit Braha has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods using pores
    Patent number: 8785211
    Abstract: The invention relates to a method of identifying an individual nucleotide, comprising (a) contacting the nucleotide with a transmembrane protein pore so that the nucleotide interacts with the pore and (b) measuring the current passing through the pore during the interaction and thereby determining the identity of the nucleotide. The invention also relates to a method of sequencing nucleic acid sequences and kits related thereto.
    Type: Grant
    Filed: December 28, 2011
    Date of Patent: July 22, 2014
    Assignee: Isis Innovation Limited
    Inventors: Hagan Bayley, Yann Astier, Orit Braha
  • METHODS USING PORES
    Publication number: 20120219960
    Abstract: The invention relates to a method of identifying an individual nucleotide, comprising (a) contacting the nucleotide with a transmembrane protein pore so that the nucleotide interacts with the pore and (b) measuring the current passing through the pore during the interaction and thereby determining the identity of the nucleotide. The invention also relates to a method of sequencing nucleic acid sequences and kits related thereto.
    Type: Application
    Filed: December 28, 2011
    Publication date: August 30, 2012
    Applicant: ISIS INNOVATION LIMITED
    Inventors: Hagan BAYLEY, Yann ASTIER, Orit BRAHA
  • Methods using pores
    Patent number: 8105846
    Abstract: The invention relates to a method of identifying an individual nucleotide, comprising (a) contacting the nucleotide with a transmembrane protein pore so that the nucleotide interacts with the pore and (b) measuring the current passing through the pore during the interaction and thereby determining the identity of the nucleotide. The invention also relates to a method of sequencing nucleic acid sequences and kits related thereto.
    Type: Grant
    Filed: November 15, 2006
    Date of Patent: January 31, 2012
    Assignee: Isis Innovation Limited
    Inventors: Hagan Bayley, Yann Astier, Orit Braha
  • Methods Using Pores
    Publication number: 20080311582
    Abstract: The invention relates to a method of identifying an individual nucleotide, comprising (a) contacting the nucleotide with a transmembrane protein pore so that the nucleotide interacts with the pore and (b) measuring the current passing through the pore during the interaction and thereby determining the identity of the nucleotide. The invention also relates to a method of sequencing nucleic acid sequences and kits related thereto.
    Type: Application
    Filed: November 15, 2006
    Publication date: December 18, 2008
    Inventors: Hagan Bayley, Yann Astier, Orit Braha
  • Analyte sensing mediated by adapter/carrier molecules
    Patent number: 6927070
    Abstract: This invention relates to an improved method and system for sensing of one or more analytes. A host molecule, which serves as an adapter/carrier, is used to facilitate interaction between the analyte and the sensor element. A detectable signal is produced reflecting the identity and concentration of analyte present.
    Type: Grant
    Filed: June 25, 2002
    Date of Patent: August 9, 2005
    Assignee: The Texas A&M University System
    Inventors: Hagan Bayley, Orit Braha, LiQun Gu
  • Designed protein pores as components for biosensors
    Publication number: 20050131211
    Abstract: A mutant staphylococcal alpha hemolysin polypeptide containing a heterologous analyte-binding amino acid which assembles into an analyte-responsive heptameric pore assembly in the presence of a wild type staphylococcal alpha hemolysin polypeptide, digital biosensors, and methods of detecting, identifying, and quantifying analytes are described.
    Type: Application
    Filed: September 21, 2004
    Publication date: June 16, 2005
    Inventors: Hagan Bayley, Orit Braha, John Kasianowicz, Eric Gouaux
  • Designed protein pores as components for biosensors
    Patent number: 6824659
    Abstract: A mutant staphylococcal alpha hemolysin polypeptide containing a heterologous analyte-binding amino acid which assembles into an analyte-responsive heptameric pore assembly in the presence of a wild type staphylococcal alpha hemolysin polypeptide, digital biosensors, and methods of detecting, identifying, and quantifying analytes are described.
    Type: Grant
    Filed: February 15, 2001
    Date of Patent: November 30, 2004
    Assignee: University of Massachusetts
    Inventors: Hagan Bayley, Orit Braha, John Kasianowicz, Eric Gouaux
  • DESIGNED PROTEIN PORES AS COMPONENTS FOR BIOSENSORS
    Publication number: 20040191845
    Abstract: A mutant staphylococcal alpha hemolysin polypeptide containing a heterologous analyte-binding amino acid which assembles into an analyte-responsive heptameric pore assembly in the presence of a wild type staphylococcal alpha hemolysin polypeptide, digital biosensors, and methods of detecting, identifying, and quantifying analytes are described.
    Type: Application
    Filed: February 15, 2001
    Publication date: September 30, 2004
    Applicant: United States of America, as Represented by the Secrectary of Commerce
    Inventors: Hagan Bayley, Orit Braha, John Kasianowicz, Eric Gouaux
  • Analyte sensing mediated by adapter/carrier molecules
    Patent number: 6426231
    Abstract: This invention relates to an improved method and system for sensing of one or more analytes. A host molecule, which serves as an adapter/carrier, is used to facilitate interaction between the analyte and the sensor element. A detectable signal is produced reflecting the identity and concentration of analyte present.
    Type: Grant
    Filed: November 17, 1999
    Date of Patent: July 30, 2002
    Assignee: The Texas A&M University System
    Inventors: Hagan Bayley, Orit Braha, LiQun Gu