Patents by Inventor Orit Rozenblatt-Rosen

Orit Rozenblatt-Rosen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS TARGETING COMPLEMENT COMPONENT 3 FOR INHIBITING TUMOR GROWTH
    Publication number: 20200102386
    Abstract: This invention relates generally to compositions and methods for modulating complement component 3 (C3) activity or expression to treat, control or otherwise influence tumors and tissues, including cells and cell types of the tumors and tissues, and malignant, microenvironmental, or immunologic states of the tumor cells and tissues. The invention also relates to methods of diagnosing, prognosing and/or staging of tumors, tissues and cells.
    Type: Application
    Filed: June 14, 2018
    Publication date: April 2, 2020
    Inventors: Aviv Regev, Ana Carrizosa Anderson, Ayshwarya Subramanian, Orit Rozenblatt-Rosen
  • COMPOSITIONS AND METHODS TARGETING COMPLEMENT COMPONENT 3 FOR INHIBITING TUMOR GROWTH
    Publication number: 20200023007
    Abstract: This invention relates generally to compositions and methods for modulating complement component 3 (C3) activity or expression to treat, control or otherwise influence tumors and tissues, including cells and cell types of the tumors and tissues, and malignant, microenvironmental, or immunologic states of the tumor cells and tissues. The invention also relates to methods of diagnosing, prognosing and/or staging of tumors, tissues and cells.
    Type: Application
    Filed: June 14, 2019
    Publication date: January 23, 2020
    Inventors: Aviv Regev, Ana Carrizosa Anderson, Ayshwarya Subramanian, Orit Rozenblatt-Rosen
  • DISSOCIATION OF HUMAN TUMOR TO SINGLE CELL SUSPENSION FOLLOWED BY BIOLOGICAL ANALYSIS
    Publication number: 20190367964
    Abstract: Described herein are compositions and methods of disaggregating a tissue sample into single cells.
    Type: Application
    Filed: February 2, 2017
    Publication date: December 5, 2019
    Applicants: DANA-FARBER CANCER INSTITUTE, INC., THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Benjamin Izar, Levi Garraway, Asaf Rotem, Aviv Regev, Alexander Shalek, Marc Wadsworth, Sanjay Prakadan, Orit Rozenblatt-Rosen, Itay Tirosh
  • MODULATION OF INTESTINAL EPITHELIAL CELL DIFFERENTIATION, MAINTENANCE AND/OR FUNCTION THROUGH T CELL ACTION
    Publication number: 20190263912
    Abstract: An atlas of intestinal epithelial cells, intestinal epithelial stem cells and intestinal immune cells identifies new cell populations, markers, networks, and responses to stimuli. Intestinal T cells drive intestinal epithelial cell differentiation and activity. Accordingly, disclosed are methods of modulating intestinal epithelial cell differentiation, maintenance and/or function, related methods for the treatment of disease, including IBD. Also disclosed are methods and kits for identifying cell types, their differentiation, homeostasis and activation.
    Type: Application
    Filed: November 7, 2017
    Publication date: August 29, 2019
    Inventors: Adam Haber, Moshe Biton, Rebecca H. Herbst, Karthik Shekhar, Christopher Smillie, Orit Rozenblatt-Rosen, Ramnik Xavier, Aviv Regev, Jose Ordovas-Montanes, Alexander K. Shalek, Noga Rogel
  • ASSAYS FOR MASSIVELY COMBINATORIAL PERTURBATION PROFILING AND CELLULAR CIRCUIT RECONSTRUCTION
    Publication number: 20190085324
    Abstract: The present invention provides tools and methods for the systematic analysis of genetic interactions, including higher order interactions. The present invention provides tools and methods for combinatorial probing of cellular circuits, for dissecting cellular circuitry, for delineating molecular pathways, and/or for identifying relevant targets for therapeutics development.
    Type: Application
    Filed: April 27, 2018
    Publication date: March 21, 2019
    Inventors: Aviv Regev, Brittany Adamson, Brian Cleary, Le Cong, Atray Dixit, Jellert Gaublomme, Eric S. Lander, Thomas Norman, Oren Parnas, Orit Rozenblatt-Rosen, Alexander K. Shalek, Jonathan Weissman
  • TUMOR AND MICROENVIRONMENT GENE EXPRESSION, COMPOSITIONS OF MATTER AND METHODS OF USE THEREOF
    Publication number: 20180100201
    Abstract: This invention relates generally to compositions and methods for identifying genes and gene networks that respond to, modulate, control or otherwise influence tumors and tissues, including cells and cell types of the tumors and tissues, and malignant, microenvironmental, or immunologic states of the tumor cells and tissues. The invention also relates to methods of diagnosing, prognosing and/or staging of tumors, tissues and cells, and provides compositions and methods of modulating expression of genes and gene networks of tumors, tissues and cells, as well as methods of identifying, designing and selecting appropriate treatment regimens. The invention also relates to the modulation of complement activity to shift cellular immunity and obtain an effective therapeutic response.
    Type: Application
    Filed: December 17, 2017
    Publication date: April 12, 2018
    Inventors: Levi A. Garraway, Benjamin Izar, Sanjay Prakadan, Aviv Regev, Orit Rozenblatt-Rosen, Alexander K. Shalek, Mario Suva, Itay Tirosh, Andrew Venteicher, Marc H. Wadsworth II, Bradley Bernstein, Anuraag Parikh, Sidharth Puram