Patents by Inventor Orly Perl

Orly Perl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for the diagnosis of schizophrenia
    Patent number: 7939262
    Abstract: A method for the diagnosis of schizophrenia in an individual comprises: (i) measuring mRNA of either D3 dopamine receptor or ?7 nicotinic acetylcholine receptor (?7 AChR), and of a control gene in peripheral blood lymphocytes (PBLs) of the individual and of at least one healthy control individual; (ii) calculating the ratio between the receptor mRNA and the control gene mRNA for each individual; and (iii) evaluating the ratio between the ratios obtained in (ii) for the tested individual and for the at least one healthy control individual, wherein (a) an increase in the D3 dopamine receptor mRNA or a decrease in the ?7 AChR in the tested individual in comparison to healthy individuals, indicates that said tested individual has a higher likelihood of having schizophrenia than the healthy controls.
    Type: Grant
    Filed: June 23, 2009
    Date of Patent: May 10, 2011
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Sara Fuchs, Tal Ilani, Orly Perl
  • METHOD FOR THE DIAGNOSIS AND FOLLOW-UP OF SCHIZOPHRENIA AND OTHER MENTAL AND NEUROLOGICAL DISORDERS
    Publication number: 20100041043
    Abstract: A method for the diagnosis and follow up of a mental disorder or of a neurodegenerative disorder in an individual, comprises: (i) measuring mRNA of D3 dopamine receptor and/or of ?7 nicotinic acetylcholine receptor (?7 AChR) and of a control gene in peripheral blood lymphocytes (PBLs) of said individual and of at least one healthy control individual; (ii) calculating the ratio between the D3 dopamine receptor mRNA and the control gene mRNA and/or the ratio between ?7 AChR mRNA and the control gene mRNA for each individual; and (iii) evaluating the ratio between the ratios obtained in (ii) for the tested individual and for the at least one healthy control individual, wherein an increase in the D3 dopamine receptor mRNA and/or a decrease in the ?7 AChR mRNA in the tested individual in comparison to healthy individuals, indicate that said tested individual has a high likelihood of having said mental disorder or neurodegenerative disorder, wherein said increase in the D3 dopamine receptor mRNA and/or decrease in
    Type: Application
    Filed: June 23, 2009
    Publication date: February 18, 2010
    Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: Sara Fuchs, Tal Ilani, Orly Perl
  • Method for the diagnosis and follow up of schizophrenia and other mental and neurodegenerative disorders
    Publication number: 20050158715
    Abstract: A method for the diagnosis and follow up of a mental disorder or of a neurodegenerative disorder in an individual, comprises: (i) measuring mRNA of D3 dopamine receptor and/or of ?7 nicotinic acetylcholine receptor (?7 AChR) and of a control gene in peripheral blood lymphocytes (PBLs) of said individual and of at least one healthy control individual; (ii) calculating the ratio between the D3 dopamine receptor mRNA and the control gene mRNA and/or the ratio between ?7 AChR mRNA and the control gene mRNA for each individual; and (iii) evaluating the ratio between the ratios obtained in (ii) for the tested individual and for the at least one healthy control individual, wherein an increase in the D3 dopamine receptor mRNA and/or a decrease in the ?7 AChR mRNA in the tested individual in comparison to healthy individuals, indicate that said tested individual has a high likelihood of having said mental disorder or neurodegenerative disorder, wherein said increase in the D3 dopamine receptor mRNA and/or decrease in
    Type: Application
    Filed: August 15, 2001
    Publication date: July 21, 2005
    Inventors: Sara Fuchs, Tal Ilani, Orly Perl