Patents by Inventor Oron Yacoby-Zeevi

Oron Yacoby-Zeevi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Continuous Administration of Dopa Decarboxylase Inhibitors and Compositions for Same
    Publication number: 20230321019
    Abstract: Disclosed herein are compositions that include for example the arginine salt of carbidopa, and methods for treating neurological or movement diseases or disorders such as restless leg syndrome, Parkinson's disease, secondary parkinsonism, Huntington's disease, Parkinson's like syndrome, PSP, MSA, ALS, Shy-Drager syndrome and conditions resulting from brain injury including carbon monoxide or manganese intoxication, using substantially continuous administration of carbidopa or salt thereof together with administration of levodopa.
    Type: Application
    Filed: November 11, 2022
    Publication date: October 12, 2023
    Inventors: Oron Yacoby-Zeevi, Mara Nemas
  • DOPA DECARBOXYLASE INHIBITOR COMPOSITIONS
    Publication number: 20230240980
    Abstract: Disclosed herein are formulations containing carbidopa and optionally levodopa, arginine, and other components that have reduced levels of impurities and toxins, particularly degradation productions. Also disclosed herein are methods of treatment diseases or conditions relating to a loss of dopamine or dopaminergic neurons using such formulations, methods of making such formulations, and kits that include such formulations.
    Type: Application
    Filed: September 1, 2022
    Publication date: August 3, 2023
    Inventor: Oron Yacoby-Zeevi
  • COMPOSITIONS COMPRISING CIPROFLOXACIN AND CELECOXIB
    Publication number: 20230120880
    Abstract: Embodiments relate to a tablet comprising celecoxib and ciprofloxacin or a pharmaceutically acceptable salt thereof, and low viscosity hydroxypropyl methylcellulose having a viscosity of less than 150 cP, when measured as a 2% solution in water at 20° C.
    Type: Application
    Filed: October 18, 2022
    Publication date: April 20, 2023
    Applicant: Neurosense Therapeutics Ltd.
    Inventors: Alon Ben Noon, Jeffrey Sterling, Oron Yacoby-Zeevi, Sharon Cohen Vered
  • DOPA DECARBOXYLASE INHIBITOR COMPOSITIONS
    Publication number: 20230096364
    Abstract: Disclosed herein are formulations containing carbidopa and optionally levodopa, arginine, and other components that have reduced levels of impurities and toxins, particularly degradation productions. Also disclosed herein are methods of treatment diseases or conditions relating to a loss of dopamine or dopaminergic neurons using such formulations, methods of making such formulations, and kits that include such formulations.
    Type: Application
    Filed: May 10, 2022
    Publication date: March 30, 2023
    Inventor: Oron Yacoby-Zeevi
  • Continuous Administration of L-Dopa, Dopa Decarboxylase Inhibitors, Catechol-O-Methyl Transferase Inhibitors and Compositions for Same
    Publication number: 20230047523
    Abstract: Provided herein, in part, is a method of treating a neurological or movement disorder in a patient in need thereof, comprising subcutaneously administering to said patient a pharmaceutically acceptable composition comprising levodopa and optionally carbidopa and optionally entacapone or tolcapone, or pharmaceutically acceptable salts thereof, wherein said composition is administered substantially continuously, and compositions that can be used in the disclosed methods.
    Type: Application
    Filed: March 16, 2022
    Publication date: February 16, 2023
    Inventors: Oron Yacoby-Zeevi, Mara Nemas
  • METHOD FOR TREATMENT OF PARKINSON'S DISEASE
    Publication number: 20230047847
    Abstract: The present invention provides a method for treatment of a neurological or movement disorder, e.g., Parkinson's disease, in an individual in need thereof, by parenteral administration of a composition comprising carbidopa and levopoda, or pharmaceutically acceptable salts thereof, and concomitant oral administration of a catechol-O-methyl transferase (COMT) inhibitor, e.g., entacapone or tolcapone.
    Type: Application
    Filed: March 18, 2022
    Publication date: February 16, 2023
    Inventor: Oron Yacoby-Zeevi
  • METHOD FOR TREATMENT OF PARKINSON'S DISEASE
    Publication number: 20210093560
    Abstract: The present invention provides a method for treatment of a neurological or movement disorder, e.g., Parkinson's disease, in an individual in need thereof, by parenteral administration of a composition comprising carbidopa and levopoda, or pharmaceutically acceptable salts thereof, and concomitant oral administration of a catechol-O-methyl transferase (COMT) inhibitor, e.g., entacapone or tolcapone.
    Type: Application
    Filed: May 18, 2020
    Publication date: April 1, 2021
    Inventor: Oron Yacoby-Zeevi
  • Continuous Administration of Dopa Decarboxylase Inhibitors and Compositions for Same
    Publication number: 20210077442
    Abstract: Disclosed herein are compositions that include for example the arginine salt of carbidopa, and methods for treating neurological or movement diseases or disorders such as restless leg syndrome, Parkinson's disease, secondary parkinsonism, Huntington's disease, Parkinson's like syndrome, PSP, MSA, ALS, Shy-Drager syndrome and conditions resulting from brain injury including carbon monoxide or manganese intoxication, using substantially continuous administration of carbidopa or salt thereof together with administration of levodopa.
    Type: Application
    Filed: April 30, 2020
    Publication date: March 18, 2021
    Inventors: Oron Yacoby-Zeevi, Mara Nemas
  • DOPA DECARBOXYLASE INHIBITOR COMPOSITIONS
    Publication number: 20210038505
    Abstract: Disclosed herein are formulations containing carbidopa and optionally levodopa, arginine, and other components that have reduced levels of impurities and toxins, particularly degradation productions. Also disclosed herein are methods of treatment diseases or conditions relating to a loss of dopamine or dopaminergic neurons using such formulations, methods of making such formulations, and kits that include such formulations.
    Type: Application
    Filed: March 16, 2020
    Publication date: February 11, 2021
    Inventor: Oron Yacoby-Zeevi
  • DOPA DECARBOXYLASE INHIBITOR COMPOSITIONS
    Publication number: 20210000777
    Abstract: Disclosed herein are formulations containing carbidopa and optionally levodopa, arginine, and other components that have reduced levels of impurities and toxins, particularly degradation productions. Also disclosed herein are methods of treatment diseases or conditions relating to a loss of dopamine or dopaminergic neurons using such formulations, methods of making such formulations, and kits that include such formulations.
    Type: Application
    Filed: September 24, 2020
    Publication date: January 7, 2021
    Inventor: Oron Yacoby-Zeevi
  • Continuous Administration of L-Dopa, Dopa Decarboxylase Inhibitors, Catechol-O-Methyl Transferase Inhibitors and Compositions for Same
    Publication number: 20200397730
    Abstract: Provided herein, in part, is a method of treating a neurological or movement disorder in a patient in need thereof, comprising subcutaneously administering to said patient a pharmaceutically acceptable composition comprising levodopa and optionally carbidopa and optionally entacapone or tolcapone, or pharmaceutically acceptable salts thereof, wherein said composition is administered substantially continuously, and compositions that can be used in the disclosed methods.
    Type: Application
    Filed: January 22, 2020
    Publication date: December 24, 2020
    Inventors: Oron Yacoby-Zeevi, Mara Nemas
  • DOPA decarboxylase inhibitor compositions
    Patent number: 10813902
    Abstract: Disclosed herein are formulations containing carbidopa and optionally levodopa, arginine, and other components that have reduced levels of impurities and toxins, particularly degradation productions. Also disclosed herein are methods of treatment diseases or conditions relating to a loss of dopamine or dopaminergic neurons using such formulations, methods of making such formulations, and kits that include such formulations.
    Type: Grant
    Filed: March 14, 2019
    Date of Patent: October 27, 2020
    Assignee: NeuroDerm, Ltd.
    Inventor: Oron Yacoby-Zeevi
  • Dopa decarboxylase inhibitor compositions
    Patent number: 10624839
    Abstract: Disclosed herein are formulations containing carbidopa and optionally levodopa, arginine, and other components that have reduced levels of impurities and toxins, particularly degradation productions. Also disclosed herein are methods of treatment diseases or conditions relating to a loss of dopamine or dopaminergic neurons using such formulations, methods of making such formulations, and kits that include such formulations.
    Type: Grant
    Filed: June 14, 2018
    Date of Patent: April 21, 2020
    Assignee: NeuroDerm, Ltd.
    Inventor: Oron Yacoby-Zeevi
  • DOPA DECARBOXYLASE INHIBITOR COMPOSITIONS
    Publication number: 20200046665
    Abstract: Disclosed herein are formulations containing carbidopa and optionally levodopa, arginine, and other components that have reduced levels of impurities and toxins, particularly degradation productions. Also disclosed herein are methods of treatment diseases or conditions relating to a loss of dopamine or dopaminergic neurons using such formulations, methods of making such formulations, and kits that include such formulations.
    Type: Application
    Filed: March 14, 2019
    Publication date: February 13, 2020
    Inventor: Oron Yacoby-Zeevi
  • Compositions comprising apomorphine and organic acids and uses thereof
    Patent number: 10525134
    Abstract: The present invention provides stable liquid or semi-solid pharmaceutical compositions of apomorphine, more particularly composition comprising apomorphine and an organic acid, which are useful in treatment of neurological or movement diseases or disorders, e.g., Parkinson's disease, or conditions associated therewith.
    Type: Grant
    Filed: November 10, 2017
    Date of Patent: January 7, 2020
    Assignee: NeuroDerm, Ltd.
    Inventors: Oron Yacoby-Zeevi, Mara Nemas
  • DOPA DECARBOXYLASE INHIBITOR COMPOSITIONS
    Publication number: 20190151233
    Abstract: Disclosed herein are formulations containing carbidopa and optionally levodopa, arginine, and other components that have reduced levels of impurities and toxins, particularly degradation productions. Also disclosed herein are methods of treatment diseases or conditions relating to a loss of dopamine or dopaminergic neurons using such formulations, methods of making such formulations, and kits that include such formulations.
    Type: Application
    Filed: June 14, 2018
    Publication date: May 23, 2019
    Inventor: Oron Yacoby-Zeevi
  • Continuous Administration of Dopa Decarboxylase Inhibitors and Compositions for Same
    Publication number: 20190125708
    Abstract: Disclosed herein are compositions that include for example the arginine salt of carbidopa, and methods for treating neurological or movement diseases or disorders such as restless leg syndrome, Parkinson's disease, secondary parkinsonism, Huntington's disease, Parkinson's like syndrome, PSP, MSA, ALS, Shy-Drager syndrome and conditions resulting from brain injury including carbon monoxide or manganese intoxication, using substantially continuous administration of carbidopa or salt thereof together with administration of levodopa.
    Type: Application
    Filed: May 30, 2018
    Publication date: May 2, 2019
    Inventors: Oron Yacoby-Zeevi, Mara Nemas
  • DOPA decarboxylase inhibitor compositions
    Patent number: 10258585
    Abstract: Disclosed herein are formulations containing carbidopa and optionally levodopa, arginine, and other components that have reduced levels of impurities and toxins, particularly degradation productions. Also disclosed herein are methods of treatment diseases or conditions relating to a loss of dopamine or dopaminergic neurons using such formulations, methods of making such formulations, and kits that include such formulations.
    Type: Grant
    Filed: February 21, 2017
    Date of Patent: April 16, 2019
    Assignee: NeuroDerm, Ltd.
    Inventor: Oron Yacoby-Zeevi
  • COMPOSITIONS COMPRISING APOMORPHINE AND ORGANIC ACIDS AND USES THEREOF
    Publication number: 20180303939
    Abstract: The present invention provides stable liquid or semi-solid pharmaceutical compositions of apomorphine, more particularly composition comprising apomorphine and an organic acid, which are useful in treatment of neurological or movement diseases or disorders, e.g., Parkinson's disease, or conditions associated therewith.
    Type: Application
    Filed: November 10, 2017
    Publication date: October 25, 2018
    Inventors: Oron Yacoby-Zeevi, Mara Nemas
  • Dopa decarboxylase inhibitor compositions
    Patent number: 10022320
    Abstract: Disclosed herein are formulations containing carbidopa and optionally levodopa, arginine, and other components that have reduced levels of impurities and toxins, particularly degradation productions. Also disclosed herein are methods of treatment diseases or conditions relating to a loss of dopamine or dopaminergic neurons using such formulations, methods of making such formulations, and kits that include such formulations.
    Type: Grant
    Filed: March 12, 2015
    Date of Patent: July 17, 2018
    Assignee: NeuroDerm, Ltd.
    Inventor: Oron Yacoby-Zeevi