Patents by Inventor Orvo Ast

Orvo Ast has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4211843
    Abstract: The disclosure describes a process for the production of an attenuated strain of measles virus effective for the production of an attenuated measles virus vaccine. The starting material is an Edmonston strain of measles virus which has undergone a plurality of culture passages in various culture media. A sample of the last culture passage is taken and a plurality of culture passages of the sample is effected in primary cultures of fibroblasts of chicken embryos. A sample from the last culture passage is inoculated and a culture passage is effected in a primary culture of fibroblasts of chicken embryos thereby obtaining clones of virus. Clones of measles virus obtained in the last culture passage are isolated and one selects those which are thermosensitive at a temperature between about 32.degree. C. and 37.degree. C.
    Type: Grant
    Filed: November 30, 1977
    Date of Patent: July 8, 1980
    Assignee: L'Institut Armand-Frappier
    Inventors: Robert Dubreuil, deceased, Orvo Ast, Vytautas Pavilanis