Patents by Inventor Osama A. A. Ahmed

Osama A. A. Ahmed has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Icariin nano-pharmaceutical formulation
    Patent number: 11559495
    Abstract: A nano-pharmaceutical formulation, comprising zein nanoparticles, icariin (ICA) or a pharmaceutically acceptable salt thereof encapsulated within the zein nanoparticles, at least one solubilizer, wherein the at least one solubilizer comprises D-a-Tocopherol polyethylene glycol 1000 succinate (TPGS), and one or more pharmaceutical penetration enhancers is provided. Methods of enhancing libido by administering a composition as described herein is also provided.
    Type: Grant
    Filed: March 7, 2022
    Date of Patent: January 24, 2023
    Assignee: KING ABDULAZIZ UNIVERSITY
    Inventors: Hani Z. Asfour, Nabil A. Alhakamy, Raed I. Felimban, Osama A. A. Ahmed, Waleed Y. Rizg, Usama A. Fahmy, Ashraf B. Abdel-Naim
  • Thioctamer expedites wound healing
    Patent number: 11497765
    Abstract: Thioctamer, a nanoconjugate of glatiramer acetate (GA) and thioctic acid (TA), e.g. in the form of nanospheres, is provided as are compositions comprising thioctamer and methods of using the same for wound healing. Application of thioctamer to a wound accelerates wound healing, compared to control wounds that are not treated with the copolymer.
    Type: Grant
    Filed: February 27, 2022
    Date of Patent: November 15, 2022
    Assignee: KING ABDULAZIZ UNIVERSITY
    Inventors: Nabil A. Alhakamy, Usama A. Fahmy, Osama A. A. Ahmed, Basma G. Eid, Mohammed Z. Nasrullah, Ashraf B. Abdel-naim, Amgad Khedr, Gamal A. Mohamed, Mohamed W. Alrabei, Sabrin R. M. Ibrahim
  • Transfersome-containing transdermal film formulations and methods of use
    Patent number: 11185513
    Abstract: A transdermal film formulation containing transfersomes incorporated onto the transdermal film is provided. The transfersomes include avanafil, a phospholipid, and an edge activator, wherein the phospholipid to avanafil ratio is from 3.5:1 to 4.5:1 and wherein the edge activator has a hydrophilic-lipophilic (HLB) value of 2-4. Methods of making the transdermal film formulation and methods of delivering avanafil using the transdermal film formulation are also provided.
    Type: Grant
    Filed: May 7, 2021
    Date of Patent: November 30, 2021
    Assignee: KING ABDULAZIZ UNIVERSITY
    Inventors: Khalid M. El-Say, Omar D. Al-hejaili, Abdullah A. Alamoudi, Osama A. A. Ahmed
  • Micellles containing alpha lipoic acid as a transdermal drug delivery system
    Patent number: 10799455
    Abstract: Micelle formulations comprising a tocopherol or derivative thereof, alpha lipoic acid, and a biologically active agent such as vinpocetine are provided. Films for transdermal delivery containing the micelle formulation and methods of treating cognitive and cerebrovascular disorders are also provided.
    Type: Grant
    Filed: December 13, 2019
    Date of Patent: October 13, 2020
    Assignee: King Abdulaziz University
    Inventors: Osama A. A. Ahmed, Khalid M. El-Say, Bader M. Aljaeid, Shaimaa M. Badr-Eldin, Tarek A. Ahmed
  • Development of an optimized avanafil-loaded invasomal transdermal film
    Patent number: 10751294
    Abstract: Nanosized avanafil (AVA) invasomes with enhanced transdermal delivery are provided. AVA invasomes were prepared with a vesicular size of 109.92 nm and an entrapment efficiency of 96.98%. The AVA invasomal film showed enhanced ex vivo permeation bioavailability compared to a raw AVA film.
    Type: Grant
    Filed: November 6, 2019
    Date of Patent: August 25, 2020
    Assignee: King Abdulaziz University
    Inventors: Osama A. A. Ahmed, Shaimaa M. Badr-Eldin
  • In situ gelling composition containing tocopherol-loaded micelles as an intranasal drug delivery system
    Patent number: 10736843
    Abstract: Methods of enhancing cognition and/or memory and methods of treating cognitive and cerebrovascular disorders by intranasally administering an in situ gelling composition comprising micelles formed with tocopherol or a derivative thereof are provided. The micelles encapsulate a biological active agent such as vinpocetine. The methods provide for enhanced brain targeting of the biological active agent.
    Type: Grant
    Filed: November 22, 2019
    Date of Patent: August 11, 2020
    Assignee: KING ABDULAZIZ UNIVERSITY
    Inventors: Tarek A. Ahmed, Khalid M. El-Say, Osama A. A. Ahmed, Bader M. Aljaeid
  • Polymeric nanoparticulate formulation to enhance the oral bioavailability of dapoxetine
    Patent number: 10653634
    Abstract: Dapoxetine nanoparticles comprising zein and alpha lipoic acid (ALA) are provided. When present in zein-ALA loaded nanoparticles, dapoxetine exhibits increased bioavailability (compared to conventional formulations) when administered to subjects for the prevention or treatment of premature ejaculation (PE). Thus, lower doses are administered, and side effects are attenuated or eliminated.
    Type: Grant
    Filed: December 18, 2019
    Date of Patent: May 19, 2020
    Assignees: King Abdulaziz University, Virginia Commonwealth University
    Inventors: Khalid M. El-Say, Osama A. A. Ahmed, Amir I. Mohamed, Abdelsattar M. Omar, Martin K. Safo
  • Cardioprotective nano-pharmaceutical formulation
    Patent number: 10653666
    Abstract: A nano-pharmaceutical formulation, comprising pumpkin seed oil; D-?-tocopheryl polyethylene glycol succinate (TPGS); and polyethylene glycol (PEG) 200 is provided. Additional cardioprotective therapies such as quercetin may be included in the formulation. Methods of treating cardiac dysfunction by administering the formulation are also provided.
    Type: Grant
    Filed: January 14, 2020
    Date of Patent: May 19, 2020
    Assignee: KING ABDULAZIZ UNIVERSITY
    Inventors: Osama A. A. Ahmed, Usama A. Fahmy, Noura A. Hassan, Ahmad S. Azhar, Mahmoud M. El-Mas, Hany El-Bassossy