Patents by Inventor Osami Takenouchi

Osami Takenouchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Indole derivatives exhibiting chymase-inhibitory activities and process for preparation thereof
    Patent number: 6852734
    Abstract: According to this invention, there is provided an indole derivative having the general formula (I) wherein A is an oxygen atom or a nitrogen atom which nitrogen atom is optionally substituted with an alkyl group, and (i) R1 and R2 each stand for a hydrogen atom or an alkyl group, independently, or (ii) R1 and R2 as taken together form a cycloalkyl group or an aromatic ring, or (iii) R1 and R2 as taken together form a heterocyclic ring, and R3 is a hydrogen atom, a (C1-C10)alkyl group or others, R4 is a substituted alkyl group and R5 is a hydrogen atom, a halogen atom, an alkyl group or an alkoxy group and so on, as novel compounds by a novel chemical synthetic process. The indole derivative of formula (I) exhibits a useful chymase inhibitory activity.
    Type: Grant
    Filed: May 1, 2001
    Date of Patent: February 8, 2005
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Yasuo Yamamoto, Kenzo Hariyama, Yumiko Yanagisawa, Sojiro Shiokawa, Takumi Takeyasu, Osami Takenouchi, Hidenori Kasai
  • Novel indole derivatives exhibiting chymase-inhibitory activities and process for preparation thereof
    Publication number: 20040058963
    Abstract: According to this invention, there is provided an indole derivative having the general formula (I) 1
    Type: Application
    Filed: January 10, 2003
    Publication date: March 25, 2004
    Inventors: Yasuo Yamamoto, Kenzo Hariyama, Yumiko Yanagisawa, Sojiro Shiokawa, Takumi Takeyasu, Osami Takenouchi, Hidenori Kasai
  • Cyclic amine derivatives and their use as drugs
    Patent number: 6451842
    Abstract: A compound represented by the general formula (I), a pharmaceutically acceptable acid addition salt thereof or a pharmaceutically acceptable C1-C6 alkyl addition salt thereof, and their medical applications. These compounds inhibit the action of chemokines such as MIP-1&agr; and/or MCP-1 on target cells, and are useful as therapeutic and/or preventative drugs in diseases, such as atherosclerosis, rheumatoid arthritis, and the like where blood monocytes and lymphocytes infiltrate into tissues.
    Type: Grant
    Filed: May 16, 2000
    Date of Patent: September 17, 2002
    Assignees: Dupont Pharmaceuticals Company, Teijin Limited
    Inventors: Tatsuki Shiota, Ken-ichiro Kataoka, Minoru Imai, Takaharu Tsutsumi, Masaki Sudoh, Ryo Sogawa, Takuya Morita, Takahiko Hada, Yumiko Muroga, Osami Takenouchi, Minoru Furuya, Noriaki Endo, Christine M. Tarby, Wilna Moree, Steven Teig
  • SF2809-I,II,III,IV,V and VI substances exhibiting chymase-inhibiting activities
    Patent number: 6432978
    Abstract: As novel compounds which possess a chymase-inhibiting activity and are useful as medicines for a variety of applications, there are provided SF2809-I substance, SF2809-II substance, SF2809-III substance, SF2809-IV substance, SF2809-V substance and SF2809-VI substance which are represented by the following general formula (VII) wherein R1 is a hydrogen atom, phenyl group or p-hydroxyphenyl group, and R2 is acetylamino group —NHCOCH3 or hydroxyl group, or pharmaceutically acceptable salts thereof, and which possess the chymase-inhibiting activity. Also provided is a process for the preparation of the above SF2809 substances, as well as a pharmaceutical composition comprising one of those substances.
    Type: Grant
    Filed: May 31, 2001
    Date of Patent: August 13, 2002
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Masato Tani, Yasuhiro Gyobu, Chieko Moriyama, Toru Sasaki, Osami Takenouchi, Takashi Kawamura, Takashi Kamimura, Toshiaki Harada
  • Cyclic amine derivatives and their use as drugs
    Patent number: 6410566
    Abstract: A compound represented by the general formula (I), a pharmaceutically acceptable acid addition salt thereof or a pharmaceutically acceptable C1-C6 alkyl addition salt thereof, and their medical applications. These compounds inhibit the action of chemokines such as MIP-1&agr; and/or MCP-1 on target cells, and are useful as therapeutic and/or preventative drugs in diseases, such as atherosclerosis, rheumatoid arthritis, and the like where blood monocytes and lymphocytes infiltrate into tissues.
    Type: Grant
    Filed: July 16, 2001
    Date of Patent: June 25, 2002
    Assignees: Teijin Limited, Dupont Phamaceuticals Company
    Inventors: Tatsuki Shiota, Ken-ichiro Kataoka, Minoru Imai, Takaharu Tsutsumi, Masaki Sudoh, Ryo Sogawa, Takuya Morita, Takahiko Hada, Yumiko Muroga, Osami Takenouchi, Minoru Furuya, Noriaki Endo, Christine M. Tarby, Wilna Moree, Steven Teig
  • Cyclic amine derivatives and their use as drugs
    Patent number: 6362177
    Abstract: A compound represented by the general formula (I), a pharmaceutically acceptable acid addition salt thereof or a pharmaceutically acceptable C1-C6 alkyl addition salt thereof, and their medical applications. These compounds inhibit the action of chemokines such as MIP-1&agr; and/or MCP-1 on target cells, and are useful as therapeutic and/or preventative drugs in diseases, such as atheroclerosis, rheumatoid arthritis, and the like where blood monocytes and lymphocytes infiltrate into tissues.
    Type: Grant
    Filed: July 16, 2001
    Date of Patent: March 26, 2002
    Assignees: Teijin Limited, Dupont Pharmaceuticals Research Laboratories
    Inventors: Tatsuki Shiota, Ken-ichiro Kataoka, Minoru Imai, Takaharu Tsutsumi, Masaki Sudoh, Ryo Sogawa, Takuya Morita, Takahiko Hada, Yumiko Muroga, Osami Takenouchi, Minoru Furuya, Noriaki Endo, Christine M. Tarby, Wilna Moree, Steven Teig
  • Lactone compound and process of production thereof
    Patent number: 5604257
    Abstract: A lactone compound, useful as an osteogenetic accelerator, having the formula (I): ##STR1## wherein n is zero or 1 and m is zero or 1, provided that both n and m are not zero at the same time, or a stereoisomer thereof at the 23- and/or 25-positions or any mixture thereof and a production process thereof.
    Type: Grant
    Filed: February 4, 1994
    Date of Patent: February 18, 1997
    Assignee: Teijin Limited
    Inventors: Masayasu Tabe, Kenji Manabe, Koji Tomimori, Atsuo Hazato, Osami Takenouchi, Yoshiaki Azuma