Abstract: Broad spectrum antibiotics are provided which are compounds of the formula: ##STR1## wherein R.sup.4 is a residue of a nucleophilic compound and R.sup.5 is hydroxyl or protected hydroxyl; or a pharmaceutically acceptable salt or ester thereof.

Abstract: Broad spectrum antibiotics are provided which are compounds of the formula: ##STR1## wherein -W-R is a residue of a nucleophilic compound and R.sup.5 is hydroxyl or protected hydroxyl, or a pharmaceutically acceptable salt or 4-carboxy ester which is the alkoxymethyl, .alpha.-alkoxyethyl, .alpha.-alkoxy-.alpha.-substituted methyl, alkylthiomethyl, acyloxymethyl or .alpha.-acyloxy-.alpha.-substituted methyl ester thereof.

Abstract: The multistep fluid control valve comprises a valve case having a plurality of valve seats. A valve stem is provided in the valve case and is capable of being continuously or stepwise displaced axially. At least one valve body is shiftably mounted on the valve stem it is urged toward the corresponding one of the valve seats, but normally arrested at a position clear of the valve seat. This valve body closes the valve seat when the valve stem is moved a predetermined amount. At least one further valve body is provided axially in line with the valve stem so as to cooperate with a corresponding one of the valve seats. The further valve body is actuated by a further stepwise movement of the valve stem so that the corresponding valve seat is opened or closed by the further valve body.