Patents by Inventor Osamu Hayashida

Osamu Hayashida has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10047353
    Abstract: Recombinant collagenases with a stable specific activity and enzyme agents for cell and tissue dissociation such a recombinant are provided. The recombinant collagenase is derived from Grimontia hollisae-derived collagenase is characterized by having, from the N terminus to the C terminus, a collagenase catalytic domain, a linker region sequence, and a prepeptidase C terminal domain, which Grimontia hollisae-derived recombinant collagenase does not comprise at least the prepeptidase C terminal domain. The obtained recombinant collagenase has a high and stable specific activity.
    Type: Grant
    Filed: March 6, 2015
    Date of Patent: August 14, 2018
    Assignees: Nippi, Incorporated, The University of Tokyo
    Inventors: Naoko Teramura, Katsumasa Iijima, Osamu Hayashida, Keisuke Tanaka, Shunji Hattori, Teru Okitsu, Shoji Takeuchi
  • Patent number: 10011701
    Abstract: A fluorosilicone rubber composition is provided comprising (A) a fluorosilicone gum having an aliphatic unsaturated monovalent hydrocarbon group content of 0.03-1 mol % based on the total of monovalent hydrocarbon groups and a residual alkali metal content of up to 20 ppm, (B) reinforcing silica having a specific surface area of 50-100 m2/g, and (C) an organic peroxide catalyst. The composition is molded into silicone rubber parts which are improved in compression set even after immersion in ?-caprolactam.
    Type: Grant
    Filed: December 2, 2014
    Date of Patent: July 3, 2018
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Osamu Hayashida, Kazuhiro Oishi, Atsuhito Kashima
  • Patent number: 9777157
    Abstract: A fluorosilicone rubber composition comprising (A) an alkenyl-rich fluorosilicone gum, (B) an alkenyl-poor fluorosilicone gum, (C) reinforcing silica, and (D) a curing catalyst cures into a product which experiences little change of physical strength even after immersion in alcohol-containing fuel oil.
    Type: Grant
    Filed: March 12, 2015
    Date of Patent: October 3, 2017
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Osamu Hayashida, Takao Uno, Kazuhiro Oishi, Atsuhito Kashima
  • Publication number: 20170218352
    Abstract: Recombinant collagenases with a stable specific activity and enzyme agents for cell and tissue dissociation such a recombinant are provided. The recombinant collagenase is derived from Grimontia hollisae-derived collagenase is characterized by having, from the N terminus to the C terminus, a collagenase catalytic domain, a linker region sequence, and a prepeptidase C terminal domain, which Grimontia hollisae-derived recombinant collagenase does not comprise at least the prepeptidase C terminal domain. The obtained recombinant collagenase has a high and stable specific activity.
    Type: Application
    Filed: March 6, 2015
    Publication date: August 3, 2017
    Inventors: Naoko Teramura, Katsumasa Iijima, Osamu Hayashida, Keisuke Tanaka, Shunji Hattori, Teru Okitsu, Shoji Takeuchi
  • Publication number: 20160369143
    Abstract: The present invention relates to a silicone rubber composition comprising: (A) 100 parts by mass of an organopolysiloxane that has a degree of polymerization of 100 or more and contains at least two alkenyl groups each bound to a silicon atom in the molecule; (B) 10 to 100 parts by mass of a reinforcing silica having a specific surface area (BET method) of 50 m2/g or more; (C) 1 to 100 parts by mass of calcined mica having an average particle diameter of 20 ?m or less; and (D) an effective amount of a curing agent. According to the present invention, even when a silicone rubber molded article is exposed to flame for a long time, ash of the silicone rubber molded article after firing is sintered (is transformed into a ceramic material) and the shape of the silicone rubber molded article before the firing (sintering) can be maintained. In addition, the rolling properties (workability) in a kneading step in the production of the silicone rubber composition is excellent.
    Type: Application
    Filed: May 21, 2014
    Publication date: December 22, 2016
    Applicant: SHIN-ETSU CHEMICAL CO., LTD.
    Inventors: Osamu HAYASHIDA, Masakatsu HOTTA, Yoshiaki KOIKE, Atsuhito KASHIMA
  • Patent number: 9486491
    Abstract: Provided are methods of producing a novel collagen peptide composition, and a DPP-4 inhibitor and antihyperglycemics that comprise the above-mentioned collagen peptide composition. Ginger rhizome-derived enzymes are added to and break down a collagen and/or gelatin solution to generate peptide compositions comprising peptides represented by X-Hyp-Gly (wherein X represents an amino acid residue other than Gly, Hyp, and Pro). The thus obtained collagen peptide composition has a high DPP-4 inhibitory activity and an excellent antihyperglycemic effect.
    Type: Grant
    Filed: July 23, 2013
    Date of Patent: November 8, 2016
    Assignee: Nippi, Incorporated
    Inventors: Yuki Taga, Masashi Kusubata, Satoshi Suzuki, Osamu Hayashida, Yoh-ichi Koyama, Shunji Hattori
  • Patent number: 9458306
    Abstract: A fluorosilicone rubber composition is provided. This composition comprises (A) 100 parts by weight of a fluorosilicone rubber compound, (B) 0.1 to 10 parts by weight of an activated carbon at a pH of up to 9, and (C) a catalytic amount of a curing catalyst. The fluorosilicone rubber composition of the invention can be used in producing a fluorosilicone rubber molded article (cured article) which is less likely to experience loss of its physical properties when brought in contact with an amine antiaging agent. Such fluorosilicone rubber molded article is suitable for use in applications such as rubber parts used near cargo plane engines.
    Type: Grant
    Filed: September 10, 2015
    Date of Patent: October 4, 2016
    Assignee: SHIN-ETSU CHEMICAL CO., LTD.
    Inventors: Osamu Hayashida, Atsuhito Kashima
  • Patent number: 9340579
    Abstract: A DPP-4 inhibitor comprising a peptide represented by the formula (1): Xe-Pro/Ala/Hyp-Xa-Xb-Xc-Xd (SEQ ID NO: 16) (wherein Xe is an amino acid residue with an isoelectric point of 5.9 to 6.3; Pro/Ala/Hyp represents Pro, Ala, or Hyp; Xa is an amino acid residue other than Hyp, Pro, and Arg, or deletion; 5 Xb is Gly, Pro, or deletion; Xc is Pro, Ala, or deletion; and Xd is an amino acid residue or deletion) as an active component. The inhibitor can be expected to bring out an effect of lowering blood glucose levels by enhancing effects of incretins; and the inhibitor may be used as a therapeutic agent for diabetes and, in addition, can act on the immune system or the like to be thus used in 10 treatment for skin diseases or the like.
    Type: Grant
    Filed: November 2, 2012
    Date of Patent: May 17, 2016
    Assignee: NIPPI, INCORPORATED
    Inventors: Osamu Hayashida, Masashi Kusubata, Yuji Atsuzawa, Yuki Taga, Youichi Koyama, Shunji Hattori
  • Publication number: 20160075853
    Abstract: A fluorosilicone rubber composition is provided. This composition comprises (A) 100 parts by weight of a fluorosilicone rubber compound, (B) 0.1 to 10 parts by weight of an activated carbon at a pH of up to 9, and (C) a catalytic amount of a curing catalyst. The fluorosilicone rubber composition of the invention can be used in producing a fluorosilicone rubber molded article (cured article) which is less likely to experience loss of its physical properties when brought in contact with an amine antiaging agent. Such fluorosilicone rubber molded article is suitable for use in applications such as rubber parts used near cargo plane engines.
    Type: Application
    Filed: September 10, 2015
    Publication date: March 17, 2016
    Applicant: SHIN-ETSU CHEMICAL CO., LTD.
    Inventors: Osamu Hayashida, Atsuki Kashima
  • Patent number: 9160011
    Abstract: For use in a fuel cell separator comprising a separator substrate, a primer layer, and an elastomeric seal, a sealing material comprises a primer composition containing Si—H groups of which the primer layer is formed, and a liquid addition-curable silicone rubber composition containing alkenyl groups and Si—H groups of which the elastomeric seal is formed. A molar ratio of the total amount of Si—H groups to the total amount of alkenyl groups per unit weight of the primer composition and the silicone rubber composition is in the range: 5.0<Si—H/alkenyl<50.0.
    Type: Grant
    Filed: February 27, 2009
    Date of Patent: October 13, 2015
    Assignees: HONDA MOTOR CO., LTD., Shin-Etsu Chemical Co., Ltd.
    Inventors: Satoru Terada, Daisuke Okonogi, Noriyuki Meguriya, Osamu Hayashida
  • Publication number: 20150259532
    Abstract: A fluorosilicone rubber composition comprising (A) an alkenyl-rich fluorosilicone gum, (B) an alkenyl-poor fluorosilicone gum, (C) reinforcing silica, and (D) a curing catalyst cures into a product which experiences little change of physical strength even after immersion in alcohol-containing fuel oil.
    Type: Application
    Filed: March 12, 2015
    Publication date: September 17, 2015
    Applicant: Shin-Etsu Chemical Co., Ltd.
    Inventors: Osamu HAYASHIDA, Takao UNO, Kazuhiro OISHI, Atsuhito KASHIMA
  • Publication number: 20150182580
    Abstract: Provided are methods of producing a novel collagen peptide composition, and a DPP-4 inhibitor and antihyperglycemics that comprise the above-mentioned collagen peptide composition. Ginger rhizome-derived enzymes are added to and break down a collagen and/or gelatin solution to generate peptide compositions comprising peptides represented by X-Hyp-Gly (wherein X represents an amino acid residue other than Gly, Hyp, and Pro). The thus obtained collagen peptide composition has a high DPP-4 inhibitory activity and an excellent antihyperglycemic effect.
    Type: Application
    Filed: July 23, 2013
    Publication date: July 2, 2015
    Applicant: Nippi, Incorporated
    Inventors: Yuki Taga, Masashi Kusubata, Satoshi Suzuki, Osamu Hayashida, Yoh-ichi Koyama, Shunji Hattori
  • Publication number: 20150166765
    Abstract: A fluorosilicone rubber composition is provided comprising (A) a fluorosilicone gum having an aliphatic unsaturated monovalent hydrocarbon group content of 0.03-1 mol % based on the total of monovalent hydrocarbon groups and a residual alkali metal content of up to 20 ppm, (B) reinforcing silica having a specific surface area of 50-100 m2/g, and (C) an organic peroxide catalyst. The composition is molded into silicone rubber parts which are improved in compression set even after immersion in ?-caprolactam.
    Type: Application
    Filed: December 2, 2014
    Publication date: June 18, 2015
    Applicant: Shin-Etsu Chemical Co., Ltd.
    Inventors: Osamu HAYASHIDA, Kazuhiro Oishi, Atsuhito Kashima
  • Publication number: 20140309401
    Abstract: A DPP-4 inhibitor comprising a peptide represented by the formula (1): Xe-Pro/Ala/Hyp-Xa-Xb-Xc-Xd (wherein Xe is an amino acid residue with an isoelectric point of 5.9 to 6.3; Pro/Ala/Hyp represents Pro, Ala, or Hyp; Xa is an amino acid residue other than Hyp, Pro, and Arg, or deletion; Xb is Gly, Pro, or deletion; Xc is Pro, Ala, or deletion; and Xd is an amino acid residue or deletion) as an active component. The inhibitor can be expected to bring out an effect of lowering blood glucose levels by enhancing effects of incretins; and the inhibitor may be used as a therapeutic agent for diabetes and, in addition, can act on the immune system or the like to be thus used in treatment for skin diseases or the like.
    Type: Application
    Filed: November 2, 2012
    Publication date: October 16, 2014
    Inventors: Osamu Hayashida, Masashi Kusubata, Yuji Atsuzawa, Yuki Taga, Youichi Koyama, Shunji Hattori
  • Patent number: 8795920
    Abstract: A rubber composition comprising (A) an alkenyl-containing organopolysiloxane, (B) a silicone resinous copolymer, (C) an organohydrogenpolysiloxane, (D) fumed silica having a BET specific surface area of 50-400 m2/g, (E) carbon powder having a BET specific surface area of 30-150 m2/g, and (F) an addition reaction catalyst cures into a product which is useful as a separator seal in PEFCs. The rubber has a reduced compression set even in an acidic atmosphere or in contact with LLC, and the rubber itself has strength and good adhesion to separator substrates. The separator provides excellent seal performance over a long term.
    Type: Grant
    Filed: December 4, 2008
    Date of Patent: August 5, 2014
    Assignees: Honda Motor Co., Ltd., Shin-Etsu Chemical Co., Ltd.
    Inventors: Daisuke Okonogi, Satoru Terada, Noriyuki Meguriya, Osamu Hayashida
  • Patent number: 8697798
    Abstract: A silicone rubber composition comprising (A) an organopolysiloxane composition of the organic peroxide cure or addition reaction cure type, (B) a normally solid organic compound having at least two ester bonds per molecule, and (C) particulate aluminum hydroxide having an average particle size of up to 20 ?m is suited for use as high-voltage electric insulator since it maintains insulating properties for a long term in outdoor service and has acid resistance and a long lifetime even in polluted areas.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: April 15, 2014
    Assignees: Shin-Etsu Chemical Co., Ltd., NGK Insulators, Ltd.
    Inventors: Noriyuki Meguriya, Yoshiaki Koike, Osamu Hayashida, Takanori Kondo, Tatsuya Kuroda
  • Publication number: 20130266799
    Abstract: A silicone rubber composition comprising (A) an organopolysiloxane composition of the organic peroxide cure or addition reaction cure type, (B) a normally solid organic compound having at least two ester bonds per molecule, and (C) particulate aluminum hydroxide having an average particle size of up to 20 ?m is suited for use as high-voltage electric insulator since it maintains insulating properties for a long term in outdoor service and has acid resistance and a long lifetime even in polluted areas.
    Type: Application
    Filed: March 14, 2013
    Publication date: October 10, 2013
    Applicants: NGK INSULATORS, LTD., SHIN-ETSU CHEMICAL CO., LTD.
    Inventors: Noriyuki MEGURIYA, Yoshiaki KOIKE, Osamu HAYASHIDA, Takanori KONDO, Tatsuya KURODA
  • Patent number: 8158302
    Abstract: A rubber composition comprising (A) a liquid alkenyl-containing organopolysiloxane with Mw<100,000, (B) a gum-like organopolysiloxane with Mw?150,000, (C) an organohydrogenpolysiloxane, (D) fumed silica, and (E) an addition reaction catalyst and having a viscosity of 20-200 Pa-s at a shear rate of 10 s?1 and 25° C. is effectively injection moldable into a cured product which is useful as a separator seal in PEFCs.
    Type: Grant
    Filed: December 4, 2008
    Date of Patent: April 17, 2012
    Assignees: Honda Motor Co., Ltd., Shin-Etsu Chemical Co., Ltd.
    Inventors: Daisuke Okonogi, Satoru Terada, Noriyuki Meguriya, Osamu Hayashida
  • Patent number: 8158738
    Abstract: An adhesive silicone rubber composition comprising (A) 100 pbw of an organopolysiloxane containing at least two silicon-bonded alkenyl radicals, (B) 0.5-20 pbw of an organohydrogenpolysiloxane containing at least two Si—H radicals, (C) a hydrosilylation catalyst, and (D) 0.1-50 pbw of an organosilicon compound having at least one phenyl structure, at least one alicyclic epoxy radical, and at least one Si—H radical is applicable to an electrolyte membrane and a separator in a polymer electrolyte fuel cell to form a firm integrally molded part.
    Type: Grant
    Filed: June 20, 2008
    Date of Patent: April 17, 2012
    Assignees: Toyota Jidosha Kabushiki Kaisha, Shin-Etsu Chemical Co., Ltd.
    Inventors: Chisato Kato, Kazutaka Iizuka, Osamu Hayashida, Takashi Aketa, Shigeki Shudo
  • Patent number: 8133949
    Abstract: Disclosed is a rubber composition for separator seal, comprising (A) a mixture of two or more alkenyl-containing liquid organopolysiloxanes having different weight average molecular weights, (B) an organohydrogenpolysiloxane, (C) fumed silica having a BET specific surface area of 50-400 m2/g, (D) carbon black having a BET specific surface area of 30 to 120 m2/g, an iodine adsorption value of 30 to 120 mg/g, and a DBP absorption value of 100 to 200 ml/100 g, and (E) an addition reaction catalyst cures into a product which is useful as a separator seal in PEFCs.
    Type: Grant
    Filed: December 4, 2008
    Date of Patent: March 13, 2012
    Assignees: Honda Motor Co., Ltd., Shin-Etsu Chemical Co., Ltd.
    Inventors: Daisuke Okonogi, Satoru Terada, Noriyuki Meguriya, Osamu Hayashida