Abstract: [Problem] An object of the present invention is to provide a millable fluorosilicone rubber composition that provides a fluorosilicone rubber (cured product) having excellent heat resistance at 200° C. or higher, and at 250° C. or higher in particular. [Solution] The present invention provides a millable fluorosilicone rubber composition comprising: (A) 100 parts by mass of an organopolysiloxane having at least two alkenyl groups each bonded a silicon atom in one molecule, having a number of siloxane units having at least one fluoroalkyl group that is 40% or more of a total number of the siloxane units, and having an average polymerization degree of 100 or more; (B) 5 to 100 parts by mass of a reinforcing silica having a specific surface area of 50 m2/g or more; (C) 0.01 to 10 parts by mass of titanium oxide denatured with the transition metal oxide, that contains 0.01 to 5% by mass of a transition metal oxide; (D) 0.01 to 10 parts by mass of calcium carbonate; and (E) 0.

Abstract: Recombinant collagenases with a stable specific activity and enzyme agents for cell and tissue dissociation such a recombinant are provided. The recombinant collagenase is derived from Grimontia hollisae-derived collagenase is characterized by having, from the N terminus to the C terminus, a collagenase catalytic domain, a linker region sequence, and a prepeptidase C terminal domain, which Grimontia hollisae-derived recombinant collagenase does not comprise at least the prepeptidase C terminal domain. The obtained recombinant collagenase has a high and stable specific activity.

Abstract: A fluorosilicone rubber composition is provided comprising (A) a fluorosilicone gum having an aliphatic unsaturated monovalent hydrocarbon group content of 0.03-1 mol % based on the total of monovalent hydrocarbon groups and a residual alkali metal content of up to 20 ppm, (B) reinforcing silica having a specific surface area of 50-100 m2/g, and (C) an organic peroxide catalyst. The composition is molded into silicone rubber parts which are improved in compression set even after immersion in ?-caprolactam.

Abstract: A fluorosilicone rubber composition comprising (A) an alkenyl-rich fluorosilicone gum, (B) an alkenyl-poor fluorosilicone gum, (C) reinforcing silica, and (D) a curing catalyst cures into a product which experiences little change of physical strength even after immersion in alcohol-containing fuel oil.

Abstract: Recombinant collagenases with a stable specific activity and enzyme agents for cell and tissue dissociation such a recombinant are provided. The recombinant collagenase is derived from Grimontia hollisae-derived collagenase is characterized by having, from the N terminus to the C terminus, a collagenase catalytic domain, a linker region sequence, and a prepeptidase C terminal domain, which Grimontia hollisae-derived recombinant collagenase does not comprise at least the prepeptidase C terminal domain. The obtained recombinant collagenase has a high and stable specific activity.

Abstract: The present invention relates to a silicone rubber composition comprising: (A) 100 parts by mass of an organopolysiloxane that has a degree of polymerization of 100 or more and contains at least two alkenyl groups each bound to a silicon atom in the molecule; (B) 10 to 100 parts by mass of a reinforcing silica having a specific surface area (BET method) of 50 m2/g or more; (C) 1 to 100 parts by mass of calcined mica having an average particle diameter of 20 ?m or less; and (D) an effective amount of a curing agent. According to the present invention, even when a silicone rubber molded article is exposed to flame for a long time, ash of the silicone rubber molded article after firing is sintered (is transformed into a ceramic material) and the shape of the silicone rubber molded article before the firing (sintering) can be maintained. In addition, the rolling properties (workability) in a kneading step in the production of the silicone rubber composition is excellent.

Abstract: Provided are methods of producing a novel collagen peptide composition, and a DPP-4 inhibitor and antihyperglycemics that comprise the above-mentioned collagen peptide composition. Ginger rhizome-derived enzymes are added to and break down a collagen and/or gelatin solution to generate peptide compositions comprising peptides represented by X-Hyp-Gly (wherein X represents an amino acid residue other than Gly, Hyp, and Pro). The thus obtained collagen peptide composition has a high DPP-4 inhibitory activity and an excellent antihyperglycemic effect.

Abstract: A fluorosilicone rubber composition is provided. This composition comprises (A) 100 parts by weight of a fluorosilicone rubber compound, (B) 0.1 to 10 parts by weight of an activated carbon at a pH of up to 9, and (C) a catalytic amount of a curing catalyst. The fluorosilicone rubber composition of the invention can be used in producing a fluorosilicone rubber molded article (cured article) which is less likely to experience loss of its physical properties when brought in contact with an amine antiaging agent. Such fluorosilicone rubber molded article is suitable for use in applications such as rubber parts used near cargo plane engines.

Abstract: A DPP-4 inhibitor comprising a peptide represented by the formula (1): Xe-Pro/Ala/Hyp-Xa-Xb-Xc-Xd (SEQ ID NO: 16) (wherein Xe is an amino acid residue with an isoelectric point of 5.9 to 6.3; Pro/Ala/Hyp represents Pro, Ala, or Hyp; Xa is an amino acid residue other than Hyp, Pro, and Arg, or deletion; 5 Xb is Gly, Pro, or deletion; Xc is Pro, Ala, or deletion; and Xd is an amino acid residue or deletion) as an active component. The inhibitor can be expected to bring out an effect of lowering blood glucose levels by enhancing effects of incretins; and the inhibitor may be used as a therapeutic agent for diabetes and, in addition, can act on the immune system or the like to be thus used in 10 treatment for skin diseases or the like.

Abstract: A fluorosilicone rubber composition is provided. This composition comprises (A) 100 parts by weight of a fluorosilicone rubber compound, (B) 0.1 to 10 parts by weight of an activated carbon at a pH of up to 9, and (C) a catalytic amount of a curing catalyst. The fluorosilicone rubber composition of the invention can be used in producing a fluorosilicone rubber molded article (cured article) which is less likely to experience loss of its physical properties when brought in contact with an amine antiaging agent. Such fluorosilicone rubber molded article is suitable for use in applications such as rubber parts used near cargo plane engines.

Abstract: For use in a fuel cell separator comprising a separator substrate, a primer layer, and an elastomeric seal, a sealing material comprises a primer composition containing Si—H groups of which the primer layer is formed, and a liquid addition-curable silicone rubber composition containing alkenyl groups and Si—H groups of which the elastomeric seal is formed. A molar ratio of the total amount of Si—H groups to the total amount of alkenyl groups per unit weight of the primer composition and the silicone rubber composition is in the range: 5.0<Si—H/alkenyl<50.0.

Abstract: A fluorosilicone rubber composition comprising (A) an alkenyl-rich fluorosilicone gum, (B) an alkenyl-poor fluorosilicone gum, (C) reinforcing silica, and (D) a curing catalyst cures into a product which experiences little change of physical strength even after immersion in alcohol-containing fuel oil.

Abstract: Provided are methods of producing a novel collagen peptide composition, and a DPP-4 inhibitor and antihyperglycemics that comprise the above-mentioned collagen peptide composition. Ginger rhizome-derived enzymes are added to and break down a collagen and/or gelatin solution to generate peptide compositions comprising peptides represented by X-Hyp-Gly (wherein X represents an amino acid residue other than Gly, Hyp, and Pro). The thus obtained collagen peptide composition has a high DPP-4 inhibitory activity and an excellent antihyperglycemic effect.

Abstract: A fluorosilicone rubber composition is provided comprising (A) a fluorosilicone gum having an aliphatic unsaturated monovalent hydrocarbon group content of 0.03-1 mol % based on the total of monovalent hydrocarbon groups and a residual alkali metal content of up to 20 ppm, (B) reinforcing silica having a specific surface area of 50-100 m2/g, and (C) an organic peroxide catalyst. The composition is molded into silicone rubber parts which are improved in compression set even after immersion in ?-caprolactam.

Abstract: A DPP-4 inhibitor comprising a peptide represented by the formula (1): Xe-Pro/Ala/Hyp-Xa-Xb-Xc-Xd (wherein Xe is an amino acid residue with an isoelectric point of 5.9 to 6.3; Pro/Ala/Hyp represents Pro, Ala, or Hyp; Xa is an amino acid residue other than Hyp, Pro, and Arg, or deletion; Xb is Gly, Pro, or deletion; Xc is Pro, Ala, or deletion; and Xd is an amino acid residue or deletion) as an active component. The inhibitor can be expected to bring out an effect of lowering blood glucose levels by enhancing effects of incretins; and the inhibitor may be used as a therapeutic agent for diabetes and, in addition, can act on the immune system or the like to be thus used in treatment for skin diseases or the like.

Abstract: A rubber composition comprising (A) an alkenyl-containing organopolysiloxane, (B) a silicone resinous copolymer, (C) an organohydrogenpolysiloxane, (D) fumed silica having a BET specific surface area of 50-400 m2/g, (E) carbon powder having a BET specific surface area of 30-150 m2/g, and (F) an addition reaction catalyst cures into a product which is useful as a separator seal in PEFCs. The rubber has a reduced compression set even in an acidic atmosphere or in contact with LLC, and the rubber itself has strength and good adhesion to separator substrates. The separator provides excellent seal performance over a long term.

Abstract: A silicone rubber composition comprising (A) an organopolysiloxane composition of the organic peroxide cure or addition reaction cure type, (B) a normally solid organic compound having at least two ester bonds per molecule, and (C) particulate aluminum hydroxide having an average particle size of up to 20 ?m is suited for use as high-voltage electric insulator since it maintains insulating properties for a long term in outdoor service and has acid resistance and a long lifetime even in polluted areas.

Abstract: A silicone rubber composition comprising (A) an organopolysiloxane composition of the organic peroxide cure or addition reaction cure type, (B) a normally solid organic compound having at least two ester bonds per molecule, and (C) particulate aluminum hydroxide having an average particle size of up to 20 ?m is suited for use as high-voltage electric insulator since it maintains insulating properties for a long term in outdoor service and has acid resistance and a long lifetime even in polluted areas.

Abstract: A rubber composition comprising (A) a liquid alkenyl-containing organopolysiloxane with Mw<100,000, (B) a gum-like organopolysiloxane with Mw?150,000, (C) an organohydrogenpolysiloxane, (D) fumed silica, and (E) an addition reaction catalyst and having a viscosity of 20-200 Pa-s at a shear rate of 10 s?1 and 25° C. is effectively injection moldable into a cured product which is useful as a separator seal in PEFCs.

Abstract: An adhesive silicone rubber composition comprising (A) 100 pbw of an organopolysiloxane containing at least two silicon-bonded alkenyl radicals, (B) 0.5-20 pbw of an organohydrogenpolysiloxane containing at least two Si—H radicals, (C) a hydrosilylation catalyst, and (D) 0.1-50 pbw of an organosilicon compound having at least one phenyl structure, at least one alicyclic epoxy radical, and at least one Si—H radical is applicable to an electrolyte membrane and a separator in a polymer electrolyte fuel cell to form a firm integrally molded part.