Patents by Inventor Osamu Ichihara
Osamu Ichihara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230086093Abstract: The present invention provides a mutant RSV F protein having a mutation, wherein the mutation is a substitution of a leucine corresponding to a leucine at position 141 of an amino acid sequence of SEQ ID NO: 1 or a leucine corresponding to a leucine at position 142 with a cysteine, and a substitution of a leucine corresponding to a leucine at position 373 with a cysteine, and a disulfide bond is formed between the cysteines. Further provided is a mutant RSV F protein having a mutation, wherein the mutation is a substitution of a glutamic acid corresponding to a glutamic acid at position 60 of the amino acid sequence of SEQ ID NO: 1 with a non-acidic amino acid.Type: ApplicationFiled: December 23, 2020Publication date: March 23, 2023Applicant: MITSUBISHI TANABE PHARMA CORPORATIONInventors: Tomoharu HOGIRI, Hiroyuki KISHIDA, Kei TAKEDOMI, Davide BRANDUARDI, Eliud OLOO, Eric FEYFANT, Osamu ICHIHARA
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Publication number: 20210147403Abstract: COMPOUNDS The present invention provides compounds of the general formula (I), their salts and N-oxides, and solvates and prodrugs thereof (wherein the substituents are as defined in the description). The compounds of the general formula (I) are inhibitors of factor XIa, and are useful in the prevention of and/or therapy for thromboembolic diseases.Type: ApplicationFiled: November 24, 2020Publication date: May 20, 2021Applicant: ONO PHARMACEUTICAL CO., LTD.Inventors: Akira IMAGAWA, Takashi KONDO, Taihei NISHIYAMA, Steve COURTNEY, Chris YARNOLD, Osamu ICHIHARA, Stuart FLANAGAN
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Patent number: 10882855Abstract: The present invention provides compounds of the general formula (I), their salts and N-oxides, and solvates and prodrugs thereof (wherein the substituents are as defined in the description). The compounds of the general formula (I) are inhibitors of factor XIa, and are useful in the prevention of and/or therapy for thromboembolic diseases.Type: GrantFiled: May 10, 2019Date of Patent: January 5, 2021Assignee: ONO PHARMACEUTICAL CO., LTD.Inventors: Akira Imagawa, Takashi Kondo, Taihei Nishiyama, Steve Courtney, Chris Yarnold, Osamu Ichihara, Stuart Flanagan
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Patent number: 10717738Abstract: The present invention provides compounds of the general formula (I), their salts and N-oxides, and solvates and prodrugs thereof (wherein the characters are as defined in the description). The compounds of the general formula (I) are inhibitors of Factor XIa, so that they are useful in the prevention of and/or therapy for thromboembolic diseases.Type: GrantFiled: July 7, 2017Date of Patent: July 21, 2020Assignee: ONO PHARMACEUTICAL CO., LTD.Inventors: Steve Courtney, Chris Yarnold, Stuart Flanagan, Gareth Brace, John Barker, Osamu Ichihara, Elise Gadouleau, Anthony Richardson, Takashi Kondo, Akira Imagawa, Shingo Nakatani, Ryo Suzuki, Sho Kouyama
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Publication number: 20190263795Abstract: The present invention provides compounds of the general formula (I), their salts and N-oxides, and solvates and prodrugs thereof (wherein the substituents are as defined in the description). The compounds of the general formula (I) are inhibitors of factor XIa, and are useful in the prevention of and/or therapy for thromboembolic diseases.Type: ApplicationFiled: May 10, 2019Publication date: August 29, 2019Applicant: ONO PHARMACEUTICAL CO., LTD.Inventors: Akira IMAGAWA, Takashi Kondo, Taihei Nishiyama, Steve Courtney, Chris Yarnold, Osamu Ichihara, Stuart Flanagan
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Patent number: 10336741Abstract: The present invention provides compounds of the general formula (I), their salts and N-oxides, and solvates and prodrugs thereof (wherein the substituents are as defined in the description). The compounds of the general formula (I) are inhibitors of factor XIa, and are useful in the prevention of and/or therapy for thromboembolic diseases.Type: GrantFiled: January 23, 2017Date of Patent: July 2, 2019Assignee: ONO PHARMACEUTICAL CO., LTD.Inventors: Akira Imagawa, Takashi Kondo, Taihei Nishiyama, Steve Courtney, Chris Yarnold, Osamu Ichihara, Stuart Flanagan
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Publication number: 20170305917Abstract: The present invention provides compounds of the general formula (I), their salts and N-oxides, and solvates and prodrugs thereof (wherein the characters are as defined in the description). The compounds of the general formula (I) are inhibitors of Factor XIa, so that they are useful in the prevention of and/or therapy for thromboembolic diseases.Type: ApplicationFiled: July 7, 2017Publication date: October 26, 2017Applicant: ONO PHARMACEUTICAL CO., LTD.Inventors: Steve COURTNEY, Chris YARNOLD, Stuart FLANAGAN, Gareth BRACE, John BARKER, Osamu ICHIHARA, Elise GADOULEAU, Anthony RICHARDSON, Takashi KONDO, Akira IMAGAWA, Shingo NAKATANI, Ryo SUZUKI, Sho KOUYAMA
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Patent number: 9732085Abstract: The present invention provides compounds of the general formula (I), their salts and N-oxides, and solvates and prodrugs thereof (wherein the characters are as defined in the description). The compounds of the general formula (I) are inhibitors of Factor XIa, so that they are useful in the prevention of and/or therapy for thromboembolic diseases.Type: GrantFiled: December 20, 2012Date of Patent: August 15, 2017Assignee: ONO PHARMACEUTICAL CO., LTD.Inventors: Steve Courtney, Chris Yarnold, Stuart Flanagan, Gareth Brace, John Barker, Osamu Ichihara, Elise Gadouleau, Anthony Richardson, Takashi Kondo, Akira Imagawa, Shingo Nakatani, Ryo Suzuki, Sho Kouyama
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Publication number: 20170137412Abstract: The present invention provides compounds of the general formula (I), their salts and N-oxides, and solvates and prodrugs thereof (wherein the substituents are as defined in the description). The compounds of the general formula (I) are inhibitors of factor XIa, and are useful in the prevention of and/or therapy for thromboembolic diseases.Type: ApplicationFiled: January 23, 2017Publication date: May 18, 2017Applicant: ONO PHARMACEUTICAL CO., LTD.Inventors: Akira IMAGAWA, Takashi KONDO, Taihei NISHIYAMA, Steve COURTNEY, Chris YARNOLD, Osamu ICHIHARA, Stuart FLANAGAN
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Patent number: 9585881Abstract: The present invention provides compounds of the general formula (I), their salts and N-oxides, and solvates and prodrugs thereof (wherein the substituents are as defined in the description). The compounds of the general formula (I) are inhibitors of factor XIa, and are useful in the prevention of and/or therapy for thromboembolic diseases.Type: GrantFiled: June 13, 2016Date of Patent: March 7, 2017Assignee: ONO PHARMACEUTICAL CO., LTD.Inventors: Akira Imagawa, Takashi Kondo, Taihei Nishiyama, Steve Courtney, Chris Yarnold, Osamu Ichihara, Stuart Flanagan
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Publication number: 20160287582Abstract: The present invention provides compounds of the general formula (I), their salts and N-oxides, and solvates and prodrugs thereof (wherein the substituents are as defined in the description). The compounds of the general formula (I) are inhibitors of factor XIa, and are useful in the prevention of and/or therapy for thromboembolic diseases.Type: ApplicationFiled: June 13, 2016Publication date: October 6, 2016Applicant: ONO PHARMACEUTICAL CO., LTD.Inventors: Akira IMAGAWA, Takashi KONDO, Taihei NISHIYAMA, Steve COURTNEY, Chris YARNOLD, Osamu ICHIHARA, Stuart FLANAGAN
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Patent number: 9394250Abstract: The present invention provides compounds of the general formula (I), their salts and N-oxides, and solvates and prodrugs thereof (wherein the substituents are as defined in the description). The compounds of the general formula (I) are inhibitors of factor XIa, and are useful in the prevention of and/or therapy for thromboembolic diseases.Type: GrantFiled: May 23, 2013Date of Patent: July 19, 2016Assignee: ONO PHARMACEUTICAL CO., LTD.Inventors: Akira Imagawa, Takashi Kondo, Taihei Nishiyama, Steve Courtney, Chris Yarnold, Osamu Ichihara, Stuart Flanagan
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Publication number: 20150152048Abstract: The present invention provides compounds of the general formula (I), their salts and N-oxides, and solvates and prodrugs thereof (wherein the substituents are as defined in the description). The compounds of the general formula (I) are inhibitors of factor XIa, and are useful in the prevention of and/or therapy for thromboembolic diseases.Type: ApplicationFiled: May 23, 2013Publication date: June 4, 2015Applicant: ONO PHARMACEUTICAL CO., LTD.Inventors: Akira Imagawa, Takashi Kondo, Taihei Nishiyama, Steve Courtney, Chris Yarnold, Osamu Ichihara, Stuart Flanagan
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Publication number: 20150152112Abstract: The present invention provides compounds of the general formula (I), their salts and N-oxides, and solvates and prodrugs thereof (wherein the characters are as defined in the description). The compounds of the general formula (I) are inhibitors of Factor XIa, so that they are useful in the prevention of and/or therapy for thromboembolic diseases.Type: ApplicationFiled: December 20, 2012Publication date: June 4, 2015Applicant: ONO PHARMACEUTICAL CO., LTD.Inventors: Steve Courtney, Chris Yarnold, Stuart Flanagan, Gareth Brace, John Barker, Osamu Ichihara, Elise Gadouleau, Anthony Richardson, Takashi Kondo, Akira Imagawa, Shingo Nakatani, Ryo Suzuki, Sho Kouyama
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Patent number: 8759520Abstract: Compounds of general formula (I): wherein R1, R2, R3, R4, R5, R6, X and Y are as defined herein are inhibitors of Bcl-2 and are useful for treating diseases characterized by abnormal cell growth and/or dysregulated apoptosis.Type: GrantFiled: December 8, 2009Date of Patent: June 24, 2014Assignee: Boehringer Ingelheim International GmbHInventors: Stephen Peter East, Mark Whittaker, Osamu Ichihara, Adrian Kotei Kotey, Smantha Jayne Bamford
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Publication number: 20110312969Abstract: Compounds of general formula (I): wherein R1, R2, R3, R4, R5, R6, X and Y are as defined herein are inhibitors of Bcl-2 and are useful for treating diseases characterised by abnormal cell growth and/or dysregulated apoptosis.Type: ApplicationFiled: December 8, 2009Publication date: December 22, 2011Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBHInventors: Stephen Peter East, Mark Whittaker, Osamu Ichihara, Adrian Kotei Kotei, Smantha Jayne Bamford
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Publication number: 20090318714Abstract: The invention related to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Aliskiren. Inter alia, the invention relates to a process for the manufacture of a compound of the formula VI, or a salt thereof, wherein R1, R2, R3 and R? are as defined in the specification, and processes of manufacturing this compound including intermediates.Type: ApplicationFiled: November 6, 2006Publication date: December 24, 2009Inventors: John Mykytiuk, Ludovic Bonnet, Stephen Gorsuch, Osamu Ichihara, Richard Mears, Christine Richardson
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Patent number: 6362433Abstract: A flexible printed circuit board that is intended to minimize curling is formed having a first polyimide-resin layer with a conductor pattern formed on one surface thereof and supporting that conductor pattern. A second polyimide-resin is formed on another surface of the conductor pattern and covers and protects the circuit of the conductor pattern. The polyimide-resin layers are chosen so that a difference between a coefficient of linear thermal expansion of the first polyimide-resin layer and the coefficient of linear thermal expansion of the second polyimide-resin layer is 3×10−6/K or smaller.Type: GrantFiled: June 4, 1999Date of Patent: March 26, 2002Assignee: Sony Chemicals CorporationInventors: Satoshi Takahashi, Akira Tsutsumi, Noriaki Kudo, Akihiro Arai, Koji Arai, Koichi Uno, Satoshi Oaku, Osamu Ichihara, Hiromasa Ota
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Patent number: 6233821Abstract: The present invention aims to obtain a flexible printed wiring board with good flatness. According to the present invention, a copper-clad film 3 is formed by applying a polyamic acid solution on one surface of a copper foil 2 and thermally contracting the polyamic acid layer la so that the other surface of the copper foil 2 may form a convex surface of a curling surface to form a polyimide film 1. A polyamic acid solution is applied on the other surface of the copper foil 2 of the copper-clad film 3, and then the polyamic acid layer 5a is thermally contracted to form a protective film 5, whereby a flexible printed wiring board 10 is obtained.Type: GrantFiled: March 15, 1999Date of Patent: May 22, 2001Assignee: Sony Chemicals Corp.Inventors: Satoshi Takahashi, Akira Tsutsumi, Noriaki Kudo, Akihiro Arai, Koji Arai, Koichi Uno, Satoshi Oaku, Osamu Ichihara, Hiromasa Ota
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Patent number: 5223641Abstract: Disclosed is a process for the production of carboxylic acids providing esters unlikely to be hydrolyzable, which comprises reacting a polyolefin containing an isobutylene unit at a rate of 60% by weight or higher with monoxide and water in the presence of a catalyst in an amount of sulfuric acid in the catalyst of 3 moles or more with respect to mole of C.dbd.C double bonds in the polyolefin and in amounts of carbon monoxide and water of at least a mole equivalent to the C.dbd.C double bonds in the polyolefin, said catalyst being a catalyst comprising a sulfuric acid aqueous solution in concentrations of 73% to 98% by weight and a catalyst comprising a sulfuric acid aqueous solution in concentrations of 73% to 98% by weight and phosphoric acid, each having an acid strength within a range from -6 to -9.Type: GrantFiled: July 20, 1992Date of Patent: June 29, 1993Assignee: Idemitsu Petrochemical Chemical Company, LimitedInventors: Hiroshi Kawasaki, Hideaki Miwa, Osamu Ichihara