Abstract: The present invention provides a compound of the formula (I) or a pharmaceutically acceptable salt thereof:

Abstract: The present invention provides a compound of the formula (I) or a pharmaceutically acceptable salt thereof:

Abstract: The present invention provides a compound having high antitumor activity, which is useful for therapeutic and preventive agents effective for proliferative diseases such as cancer; a production method thereof; an intermediate compound useful for such production; and a pharmaceutical composition comprising such a compound. The present invention provides a compound represented by the formula (1): wherein X represents an aryl group or heteroaryl group which may be substituted, Cy represents a 4- to 7-membered monocyclic heterocyclic ring or a 8- to 10-membered condensed heterocyclic ring which may be substituted, and Z represents O, S, or NRa; or a prodrug thereof; or a pharmaceutically acceptable salt thereof; and a pharmaceutical and a pharmaceutical composition which comprise the compound.

Abstract: The present invention provides a compound having high antitumor activity, which is useful for therapeutic and preventive agents effective for proliferative diseases such as cancer; a production method thereof; an intermediate compound useful for such production; and a pharmaceutical composition comprising such a compound. The present invention provides a compound represented by the formula (1): wherein X represents an aryl group or heteroaryl group which may be substituted, Cy represents a 4- to 7-membered monocyclic heterocyclic ring or a 8- to 10-membered condensed heterocyclic ring which may be substituted, and Z represents O, S, or NRa; or a prodrug thereof; or a pharmaceutically acceptable salt thereof; and a pharmaceutical and a pharmaceutical composition which comprise the compound.

Abstract: An optical divider for multimode optical fibers of graded-index (GI) type composed of an optical input section for securing input optical fiber, a branching section including an optical waveguide having rectangular sectional shapes irrespective of a kind of material or a method of fabricating the same and consists of a main optical waveguide and branch waveguide, and an optical output section for securing an array of output optical fibers, wherein the main optical waveguide having a width D and a length M is divided contiguously into N branch optical waveguides, preferably three or more having uniform width W, the optical waveguide having substantially uniform core thickness T is specifically related with the core diameter K of the otpical fiber to fufull the following relational formulas:0.7.ltoreq.T/K.ltoreq.0.85 (1)0.35.ltoreq.W/K.ltoreq.0.80 (2)15.ltoreq.M/D.ltoreq.70 (3)D=N.times.

Abstract: A main optical waveguide portion and/or branching optical waveguide portions of the optical waveguide is tapered in such a way so as to expand towards the output side for reducing a coupling loss due to mismatching of numerical apertures N.A. between optical fibers and the optical waveguide, wherein the light entering the optical waveguide at an angle determined by the numerical aperture N.A. of the optical fiber gradually reduces its angle of incidence to an interface of the core and cladding as it passes by a portion where the taper is provided and when the light reaches the output side of the optical fiber, the numerical aperture N.A. thereof is effectively reduced to a value which is lower than the numerical aperture N.A. determined by a difference of refractive-indices in the optical waveguide. By making the numerical aperture N.A.