Abstract: The object of the present invention is to provide a nucleic acid agent that is efficiently delivered to the nervous system, for example, the central nervous system to which drug delivery can be prevented by BBB, and produces an antisense effect on the target transcriptional product at the delivery site, and a composition comprising the same. In an embodiment, the present invention provides a double-stranded nucleic acid complex formed by annealing a first nucleic acid strand that hybridizes to a part of a target transcriptional product and has an antisense effect on the target transcriptional product, and a second nucleic acid strand that comprises a base sequence complementary to the first nucleic acid strand and is bound to a C22-35 alkyl group optionally substituted with a hydroxy group or an analog thereof.

Abstract: An image capture control device includes a recognition unit that determines whether a peripheral situation corresponds to a predetermined situation based on image data, and a controller that controls an infrared light irradiation unit to increase a pulse number of transmission pulses to be emitted to a target, when the recognition unit determines that the peripheral situation corresponds to the predetermined situation.

Abstract: A physiological information processing apparatus includes a processor and a memory configured to store a computer readable command. The computer readable command is executed by the processor, the physiological information processing apparatus is configured to acquire physiological information data of a subject to which an anesthetic is administered, specify, based on the physiological information data, at least one of an appropriate management time, which is a time during which anesthesia management is appropriately performed on the subject, and an inappropriate management time, which is a time during which the anesthesia management is not appropriately performed, calculate an anesthesia management evaluation index, which is an evaluation index for the anesthesia. management, based on the at least one of the inappropriate management time and the appropriate management time and an operation time of the subject, and output the calculated anesthesia management evaluation index.

Abstract: To provide an industrially useful method for producing pharmaceutically useful 4-[5-(pyridin-4-yl)-1H-1,2,4-triazol-3-yl]pyridine-2-carbonitrile, and an intermediate for producing the compound. The method for producing compound represented by formula (1) is represented by the following reaction scheme, and the intermediate is represented by the following formula (4).

Abstract: To provide an industrially useful method for producing pharmaceutically useful 4-[5-(pyridin-4-yl)-1H-1,2,4-triazol-3-yl]pyridine-2-carbonitrile, and an intermediate for producing the compound. The method for producing compound represented by formula (1) is represented by the following reaction scheme, and the intermediate is represented by the following formula (4).

Abstract: Disclosed are a novel compound and a pharmaceutical product, each having a remarkable uricosuric effect. Specifically disclosed are: a novel phenol derivative represented by general formula (1) that is shown in FIG. 1; a pharmaceutically acceptable salt thereof; a hydrate of the derivative or the salt; and a solvate of the derivative or the salt. (In the formula, R1 and R2 may be the same or different and each represents a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a lower alkoxy group, a haloalkyl group, a haloalkoxy group, an alkylsulfanyl group, an alkylsulfinyl group, an alkylsulfonyl group, a lower alkyl-substituted carbamoyl group, a saturated nitrogen-containing heterocyclic N-carbonyl group, a halogen atom, a cyano group or a hydrogen atom; R3 represents a lower alkyl group, a haloalkyl group, a halogen atom, a hydroxy group or a hydrogen atom; and X represents a sulfur atom, an —S(?O)— group or an —S(?O)2— group.

Abstract: Disclosed are a novel compound and a pharmaceutical product, each having a remarkable uricosuric effect. Specifically disclosed are: a novel phenol derivative represented by general formula (1) that is shown in FIG. 1; a pharmaceutically acceptable salt thereof; a hydrate of the derivative or the salt; and a solvate of the derivative or the salt. (In the formula, R1 and R2 may be the same or different and each represents a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a lower alkoxy group, a haloalkyl group, a haloalkoxy group, an alkylsulfanyl group, an alkylsulfinyl group, an alkylsulfonyl group, a lower alkyl-substituted carbamoyl group, a saturated nitrogen-containing heterocyclic N-carbonyl group, a halogen atom, a cyano group or a hydrogen atom; R3 represents a lower alkyl group, a haloalkyl group, a halogen atom, a hydroxy group or a hydrogen atom; and X represents a sulfur atom, an —S(?O)— group or an —S(?O)2— group.

Abstract: A compound represented by the formula (1) or a salt thereof ( represents a single bond, or a double bond; R1 represents hydrogen atom, or an alkyl group; R2 and R3 represent hydrogen atom, or an alkyl group; R4 and R5 represent hydrogen atom, hydroxy group, an alkoxyl group, a halogen atom, or a mono- or di-alkyl-substituted amino group; R6 represents hydrogen atom, cyano group, an alkoxycarbonyl group, or carboxy group; R7 represents one or two of substituents on the benzene ring (the substituents are selected from hydrogen atom, a halogen atom, nitro group, cyano group, hydroxy group, amino group, an alkyl group, and an alkoxyl group); A represents a 5-membered or 6-membered non-aromatic heterocyclic ring containing one or two contiguous sulfur atoms (the sulfur atoms may independently form oxide); W represents oxo group, hydrogen atom, an alkyl group, hydroxy group, an alkoxyl group, or a halogen atom; and X represents oxygen atom, or sulfur atom), or a salt thereof, which has a superior suppressing action

Abstract: A compound represented by the formula (1) or a salt thereof ( represents a single bond, or a double bond; R1 represents hydrogen atom, or an alkyl group; R2 and R3 represent hydrogen atom, or an alkyl group; R4 and R5 represent hydrogen atom, hydroxy group, an alkoxyl group, a halogen atom, or a mono- or di-alkyl-substituted amino group; R6 represents hydrogen atom, cyano group, an alkoxycarbonyl group, or carboxy group; R7 represents one or two of substituents on the benzene ring (the substituents are selected from hydrogen atom, a halogen atom, nitro group, cyano group, hydroxy group, amino group, an alkyl group, and an alkoxyl group); A represents a 5-membered or 6-membered non-aromatic heterocyclic ring containing one or two contiguous sulfur atoms (the sulfur atoms may independently form oxide); W represents oxo group, hydrogen atom, an alkyl group, hydroxy group, an alkoxyl group, or a halogen atom; and X represents oxygen atom, or sulfur atom), or a salt thereof, which has a superior suppressing action

Abstract: The invention provides a data storage device and a method of updating management information, capable of dealing with management information in a highly reliable manner so that information is not easily lost when an error occurs. File management information such as a FAT serving as address management information in a flash memory is stored in a management information area of the memory, a pair of blocks is assigned as blocks for use to store data of the FAT, and writing of updated FAT information is performed by alternately using the two blocks of the block pair such that previous FAT information is retained in one of the two blocks of the block pair, and updated FAT information is written in the other block of the block pair, whereby, even when an error occurs in the middle of the process of writing the updated management information, a process using the retained previous FAT information is possible.

Abstract: A medicament for preventive and/or therapeutic treatment of constipation and/or a symptom resulting from constipation which comprises magnesium polycarbophil as an active ingredient. The medicament of the present invention can exhibit high efficacy by promoting a normal defecation without causing a side effect such as a watery stool, an overloose stool, or hypercalcemia.

Abstract: The invention provides a data storage device and a method of updating management information, capable of dealing with management information in a highly reliable manner so that information is not easily lost when an error occurs. File management information such as a FAT serving as address management information in a flash memory is stored in a management information area of the memory, a pair of blocks is assigned as blocks for use to store data of the FAT, and writing of updated FAT information is performed by alternately using the two blocks of the block pair such that previous FAT information is retained in one of the two blocks of the block pair, and updated FAT information is written in the other block of the block pair, whereby, even when an error occurs in the middle of the process of writing the updated management information, a process using the retained previous FAT information is possible.

Abstract: In a vehicle air conditioner, a case member of an inside/outside air switching portion is disposed at an approximate center in an interior unit in a vehicle width direction, to define an air passage extending in the vehicle width direction. An outside air suction port is provided in the case member, and first and second openings are opened in the case member at both side ends of the air passage in the vehicle width direction. One of the first and second openings is used as an inside air suction port, and the other one thereof is used as an outlet passage port. In addition, the outlet passage port of the case member is coupled to a suction port of a blower through a connection duct.

Abstract: A recording medium on which a plurality of programs are collected in a plurality of groups and supervised in this grouped state, wherein when an editing command such as dividing, linking, and erasing the predetermined programs or groups recorded on the recording medium is executed, management data is edited to perform the editing command. The invention provides a solution to meet this request by a recording medium, an editing method and an editing apparatus.

Abstract: In an air conditioning unit of a vehicle air conditioner, an air-outlet mode switching portion is provided at an upper side of a heat exchanging portion including at least a heating heat exchanger for heating air. The air-outlet mode switching portion includes a rotary door rotatable around a rotation shaft, and the rotary door includes a circumference wall surface for opening and closing plural air outlet openings through which air is blown toward different zones of a passenger compartment. Further, the heating heat exchanger is arranged to be crossed with a horizontal surface, and a rotation space of the rotary door is provided to extend from an upper side of the heating heat exchanger to a side portion of the heating heat exchanger. Accordingly, the size of the air conditioning unit can be made smaller.

Abstract: If, in a recording medium on which a plurality of programs are collected in a plurality of groups and supervised in this grouped state, a command for editing, such as dividing/linking/erasing the predetermined programs or groups, recorded on the recording medium, the management data is to be edited to perform the editing. The present invention contemplates to provide a solution to meet this request by a recording medium, an editing method and an editing apparatus.

Abstract: If, in a recording medium on which a plurality of programs are collected in a plurality of groups and supervised in this grouped state, a command for editing, such as dividing/linking/erasing the predetermined programs or groups, recorded on the recording medium, the management data is to be edited to perform the editing. The present invention contemplates to provide a solution to meet this request by a recording medium, an editing method and an editing apparatus.

Abstract: In an air conditioning unit of a vehicle air conditioner, an air-outlet mode switching portion is provided at an upper side of a heat exchanging portion including at least a heating heat exchanger for heating air. The air-outlet mode switching portion includes a rotary door rotatable around a rotation shaft, and the rotary door includes a circumference wall surface for opening and closing plural air outlet openings through which air is blown toward different zones of a passenger compartment. Further, the heating heat exchanger is arranged to be crossed with a horizontal surface, and a rotation space of the rotary door is provided to extend from an upper side of the heating heat exchanger to a side portion of the heating heat exchanger. Accordingly, the size of the air conditioning unit can be made smaller.

Abstract: A recording medium on which a plurality of programs are collected in a plurality of groups and supervised in this grouped state, wherein when an editing command such as dividing, linking, and erasing the predetermined programs or groups recorded on the recording medium is executed, management data is edited to perform the editing command. The invention provides a solution to meet this request by a recording medium, an editing method and an editing apparatus.

Abstract: If, in a recording medium on which a plurality of programs are collected in a plurality of groups and supervised in this grouped state, a command for editing, such as dividing/linking/erasing the predetermined programs or groups, recorded on the recording medium, the management data is to be edited to perform the editing. The present invention contemplates to provide a solution to meet this request by a recording medium, an editing method and an editing apparatus.